Gene: GLMN

11146
FAP|FAP48|FAP68|FKBPAP|GLML|GVM|VMGLOM
glomulin, FKBP associated protein
protein-coding
1p22.1
Ensembl:ENSG00000174842 MIM:601749 Vega:OTTHUMG00000010283 UniprotKB:Q92990
NG_009796.1
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.416e-1 (AD)  5.019e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2025607chr1:92424787 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1906279chr1:92350591 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6668685chr1:92326255 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3103177chr1:92290950 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1487539chr1:92274142 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF250.942
DNM1L0.934
UCHL50.931
UBLCP10.931
FARSB0.927
C2CD50.925
GDAP10.923
FAM49B0.922
BBS70.921
TRAPPC6B0.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.484
OR4F5-0.473
WDR38-0.461
EVC2-0.46
FOXJ1-0.447
OR4F29-0.433
SYDE1-0.425
CNN2-0.422
RHOD-0.418
CSAG1-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of GLMN mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of GLMN mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of GLMN mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of GLMN mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of GLMN mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of GLMN mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GLMN mRNA23914054
D002945CisplatinCisplatin results in decreased expression of GLMN mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of GLMN mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GLMN mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GLMN protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLMN mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of GLMN mRNA20655997
C069837fullerene C60fullerene C60 results in increased expression of GLMN mRNA19167457
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of GLMN mRNA22634610
C016517indole-3-carbinolindole-3-carbinol affects the expression of GLMN mRNA21396975
C544151jinfukangjinfukang results in decreased expression of GLMN mRNA27392435
C045463leflunomideleflunomide results in decreased expression of GLMN mRNA28988120
C025589ochratoxin Aochratoxin A results in increased expression of GLMN mRNA14994279
D010936Plant ExtractsPlant Extracts results in increased expression of GLMN mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GLMN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GLMN mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of GLMN mRNA24780913
D011794QuercetinQuercetin results in decreased expression of GLMN mRNA21632981
D012643SeleniumSelenium results in decreased expression of GLMN mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLMN mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLMN mRNA21570461
C012589trichostatin Atrichostatin A results in increased expression of GLMN mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of GLMN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GLMN mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GLMN gene25560391
C025643vinclozolinvinclozolin results in increased expression of GLMN mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of GLMN mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005171hepatocyte growth factor receptor binding-IPI11571281  
GO:0005515protein binding-IPI11164950  12604780  25036637  
GO:0031625ubiquitin protein ligase binding-IDA22405651  
GO:0055105ubiquitin-protein transferase inhibitor activity-IBA21873635  
GO:0055105ubiquitin-protein transferase inhibitor activity-IGI22405651  
GO ID GO Term Qualifier Evidence PubMed
GO:0001570vasculogenesis-IMP11845407  
GO:0001843neural tube closure-IEA-  
GO:0031397negative regulation of protein ubiquitination-IEA-  
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP22405651  
GO:0040029regulation of gene expression, epigenetic-IMP12604780  
GO:0042130negative regulation of T cell proliferation-IDA12604780  
GO:0042327positive regulation of phosphorylation-IDA11571281  
GO:0042692muscle cell differentiation-IMP11845407  
GO:0045086positive regulation of interleukin-2 biosynthetic process-IMP12604780  
GO:0050715positive regulation of cytokine secretion-IMP12604780  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-NAS12604780  
GO:0005737cytoplasm-IBA21873635  
GO:0031461cullin-RING ubiquitin ligase complex-IPI22405651  
GO:0031462Cul2-RING ubiquitin ligase complex-IPI22405651  
GO:0031463Cul3-RING ubiquitin ligase complex-IPI22405651  
GO:0031464Cul4A-RING E3 ubiquitin ligase complex-IPI22405651  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal