Gene: GPR176

11245
HB-954
G protein-coupled receptor 176
protein-coding
15q14-q15.1
Ensembl:ENSG00000166073 MIM:612183 Vega:OTTHUMG00000129873 UniprotKB:Q14439
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.001e-1 (AD)  4.569e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17718330chr15:39831148 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC90.95
LONRF20.942
INPP4A0.939
NSF0.937
KIF3C0.937
NECAP10.936
BTBD100.936
ELMOD10.936
ARHGEF90.934
ADARB10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.489
HEY2-0.484
COPZ2-0.483
CSAG1-0.483
MYL3-0.47
RAI14-0.463
SNHG18-0.457
REST-0.457
YES1-0.453
MAGEA12-0.441

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPR176 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPR176 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GPR176 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GPR176 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPR176 mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPR176 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPR176 mRNA22300585
D004958EstradiolESR1 protein affects the reaction [Estradiol results in increased expression of GPR176 mRNA]14699072
D004958EstradiolEstradiol affects the expression of GPR176 mRNA14699072
C006780bisphenol Abisphenol A affects the expression of GPR176 mRNA25181051
D002211CapsaicinCapsaicin results in decreased expression of GPR176 mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GPR176 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GPR176 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR176 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of GPR176 mRNA22300585
D003907DexamethasoneDexamethasone results in increased expression of GPR176 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GPR176 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GPR176 mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of GPR176 mRNA25016146
D004317DoxorubicinGPR176 protein affects the susceptibility to Doxorubicin16217747
C118739entinostatentinostat results in increased expression of GPR176 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR176 mRNA20938992
C039281furanfuran results in decreased methylation of GPR176 gene27387713
C039281furanfuran results in increased expression of GPR176 mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of GPR176 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GPR176 mRNA24763279
D006418HemeHeme metabolite results in increased expression of GPR176 mRNA19191707
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GPR176 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GPR176 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GPR176 mRNA26644586
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR176 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GPR176 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GPR176 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GPR176 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPR176 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of GPR176 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GPR176 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GPR176 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPR176 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GPR176 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GPR176 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR176 mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of GPR176 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GPR176 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GPR176 mRNA25729387
D019772TopotecanTopotecan results in increased expression of GPR176 mRNA25729387
D014635Valproic AcidValproic Acid results in increased expression of GPR176 mRNA23179753|2718838
D014747VinblastineGPR176 protein affects the susceptibility to Vinblastine16217747
C111237vorinostatvorinostat results in increased expression of GPR176 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-TAS7893747  
GO:0048512circadian behavior-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7893747  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal