Gene: STX1B

112755
GEFSP9|STX1B1|STX1B2
syntaxin 1B
protein-coding
16p11.2
Ensembl:ENSG00000099365 MIM:601485 Vega:OTTHUMG00000132391 UniprotKB:P61266
NG_041829.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.894e-1 (AD)  1.764e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17855121chr16:30992848 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCAMP50.979
DNM10.976
RAB3A0.975
ATP1A30.973
ATCAY0.971
KIAA05130.969
KLC20.969
KCNAB20.968
CACNG80.968
SYNGR10.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.579
OR4F29-0.532
TFPI2-0.53
REST-0.527
WWTR1-0.525
RAI14-0.51
CNN2-0.501
YES1-0.497
SNHG18-0.492
CLEC2B-0.488

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STX1B mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of STX1B protein"21673325
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of STX1B mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STX1B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STX1B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STX1B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STX1B mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of STX1B mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of STX1B mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of STX1B mRNA28959563
D003913DextroamphetamineDextroamphetamine results in increased expression of STX1B mRNA16359582
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STX1B mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX1B mRNA22316170
C006780bisphenol Abisphenol A affects the expression of STX1B mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STX1B mRNA25607892
C096324botulinum toxin type Cbotulinum toxin type C results in increased cleavage of STX1B protein17666428
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STX1B mRNA25607892
D002330CarmustineCarmustine results in decreased expression of STX1B mRNA15980968
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of STX1B mRNA18636392
D003024ClozapineClozapine results in increased expression of STX1B mRNA15860345
D003042CocaineCocaine affects the expression of STX1B mRNA20187946
D003042CocaineCocaine results in increased expression of STX1B mRNA16076954
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of STX1B mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of STX1B mRNA28302478
D004147DioxinsDioxins affects the expression of STX1B mRNA20463971
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STX1B mRNA25607892
D000431EthanolEthanol results in decreased expression of STX1B mRNA20655511
D005419FlavonoidsFlavonoids results in decreased expression of STX1B mRNA18035473
D006220HaloperidolHaloperidol affects the expression of STX1B mRNA15860345
D017313FenretinideFenretinide results in decreased expression of STX1B mRNA28973697
D017313FenretinideFenretinide results in increased expression of STX1B mRNA28973697
C544151jinfukangjinfukang results in increased expression of STX1B mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of STX1B mRNA15469884|1680792
D007854LeadLead affects the expression of STX1B mRNA28903495
C008261lead acetatelead acetate results in decreased expression of STX1B mRNA27984133
D008731MethoxychlorMethoxychlor results in increased methylation of STX1B gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STX1B mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of STX1B mRNA"20188158
C029938nickel sulfatenickel sulfate results in increased expression of STX1B mRNA16780908
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of STX1B mRNA27935865
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of STX1B mRNA25607892
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of STX1B mRNA18636392
D010269ParaquatParaquat results in decreased expression of STX1B protein24521700
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STX1B mRNA"25510870
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of STX1B mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in increased expression of STX1B mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of STX1B mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of STX1B mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STX1B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STX1B mRNA28922406
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of STX1B mRNA29024780
D014520UrethaneUrethane results in decreased expression of STX1B mRNA28818685
D014638VanadatesVanadates results in increased expression of STX1B mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005102signaling receptor binding-IEA-  
GO:0005484SNAP receptor activity-IBA21873635  
GO:0019901protein kinase binding-ISS-  
GO:0019904protein domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001956positive regulation of neurotransmitter secretion-ISS-  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006887exocytosis-IBA21873635  
GO:0006904vesicle docking involved in exocytosis-ISS-  
GO:0006906vesicle fusion-IBA21873635  
GO:0010468regulation of gene expression-ISS-  
GO:0010807regulation of synaptic vesicle priming-ISS-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0016081synaptic vesicle docking-ISS-  
GO:0031629synaptic vesicle fusion to presynaptic active zone membrane-IBA21873635  
GO:0048278vesicle docking-IBA21873635  
GO:0048791calcium ion-regulated exocytosis of neurotransmitter-IEA-  
GO:0060025regulation of synaptic activity-ISS-  
GO:0061669spontaneous neurotransmitter secretion-IEA-  
GO:0098967exocytic insertion of neurotransmitter receptor to postsynaptic membrane-IBA21873635  
GO:0098967exocytic insertion of neurotransmitter receptor to postsynaptic membrane-IEA-  
GO:1903422negative regulation of synaptic vesicle recycling-IEA-  
GO:1904050positive regulation of spontaneous neurotransmitter secretion-IEA-  
GO:1905302negative regulation of macropinocytosis-ISS-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005819spindle-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0008021synaptic vesicle-IBA21873635  
GO:0012505endomembrane system-IBA21873635  
GO:0016020membrane-ISS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0030424axon-IEA-  
GO:0031201SNARE complex-IBA21873635  
GO:0042734presynaptic membrane-IBA21873635  
GO:0048787presynaptic active zone membrane-IBA21873635  
GO:0048787presynaptic active zone membrane-IEA-  
KEGG ID KEGG Term
hsa04130SNARE interactions in vesicular transport
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1643685DiseaseTAS
R-HSA-168799Neurotoxicity of clostridium toxinsTAS
R-HSA-5250971Toxicity of botulinum toxin type C (BoNT/C)TAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5682910LGI-ADAM interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15846778Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. (2005 May 15)Worst TJJ Neurosci Res