Gene: CYP4F8

11283
CPF8|CYPIVF8
cytochrome P450 family 4 subfamily F member 8
protein-coding
19p13.12
Ensembl:ENSG00000186526 MIM:611545 Vega:OTTHUMG00000182386 UniprotKB:P98187
NG_008068.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.501e-2 (AD)  4.904e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7256985chr19:15621260 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2176918chr19:15620112 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7254518chr19:15616955 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VCY0.611
HPGD0.61
HAL0.583
CCR30.574
TMEM710.573
TLR80.571
LEP0.554
FPR30.552
LIPN0.543
ATP8B30.542

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA4-0.266
GFRA1-0.266
CDT1-0.247
SDK2-0.242
PDZD9-0.238
RAB41-0.234
MOXD1-0.232
NRL-0.23
CCDC13-0.228
NFIX-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP4F8 mRNA21641981
C006780bisphenol Abisphenol A results in increased expression of CYP4F8 mRNA25181051
D009532NickelNickel results in decreased expression of CYP4F8 mRNA24768652
D015474IsotretinoinIsotretinoin results in decreased expression of CYP4F8 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CYP4F8 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP4F8 mRNA21998131
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP4F8 mRNA"26179874
C574123walrycin Awalrycin A results in increased expression of CYP4F8 mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0018685alkane 1-monooxygenase activity-TAS10405341  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006690icosanoid metabolic process-TAS-  
GO:0006693prostaglandin metabolic process-TAS10405341  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211979EicosanoidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal