Gene: CASC4

113201
H63
cancer susceptibility 4
protein-coding
15q15.3
Ensembl:ENSG00000166734 Vega:OTTHUMG00000131133 UniprotKB:Q6P4E1
NC_000015.10
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.545e-3 (AD)  9.216e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11856569chr15:44382642 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs8024461chr15:44290688 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCP20.929
NCBP20.896
YIPF60.895
SRP90.894
ITM2B0.892
ACADM0.892
DARS0.881
ADH50.88
COX200.878
TOR1AIP10.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.807
OR4F29-0.775
EPPIN-0.16
OR8G1-0.143
NANOS2-0.139
RNF223-0.138
CLEC6A-0.138
HMHB1-0.134
OR6C74-0.131
OR2T35-0.129

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C547126AZM551248AZM551248 results in increased expression of CASC4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CASC4 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CASC4 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CASC4 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of CASC4 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CASC4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CASC4 mRNA26079696
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CASC4 mRNA24763279
D019327Copper SulfateCopper Sulfate results in decreased expression of CASC4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CASC4 mRNA27989131
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CASC4 mRNA28962523
D004026DieldrinDieldrin results in increased expression of CASC4 mRNA20438755
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CASC4 mRNA24535843
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of CASC4 mRNA"27840820
C039281furanfuran results in increased expression of CASC4 mRNA27387713
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CASC4 mRNA24763279
C000625835HFPO2 compoundHFPO2 compound results in increased expression of CASC4 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of CASC4 mRNA27553808
D017313FenretinideFenretinide results in increased expression of CASC4 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CASC4 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CASC4 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASC4 mRNA25613284
D015741MetriboloneMetribolone results in increased expression of CASC4 mRNA17010196
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CASC4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CASC4 mRNA"25554681
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CASC4 mRNA27153767
C006253pirinixic acidpirinixic acid results in increased expression of CASC4 mRNA18301758|2381119
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CASC4 mRNA21334430
D011374ProgesteroneProgesterone results in decreased expression of CASC4 mRNA19690047
C045950propiconazolepropiconazole results in increased expression of CASC4 mRNA21278054
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASC4 mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased expression of CASC4 mRNA25549359
C012589trichostatin Atrichostatin A affects the expression of CASC4 mRNA28542535
C057693troglitazonetroglitazone results in increased expression of CASC4 mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CASC4 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of CASC4 mRNA23179753|2718838
C025643vinclozolinvinclozolin results in increased expression of CASC4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. (2011 Nov)Wang KSJ Psychiatr Res