Gene info: ID 1136

Gene: CHRNA3

GENE ID: 1136

Synonyms: LNCR2|NACHRA3|PAOD2

Description: cholinergic receptor nicotinic alpha 3 subunit

Gene type: protein-coding

Location: 15q25.1

dbXrefs: Ensembl:ENSG00000080644 MIM:118503 Vega:OTTHUMG00000143863 UniprotKB:P32297

RefSeq: NG_016143.1

Retrived from: PubMed|SNP Mapped

SNPs: 4 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 154

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.513e-1 (AD) 1.000e-12 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6495308	chr15:78615314 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs1317286	chr15:78603787 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs1051730	chr15:78601997 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs578776	chr15:78596058 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DGKK	0.794
PRLR	0.79
SLC18A3	0.789
LHX8	0.784
GPR101	0.78
AMBN	0.778
DRD3	0.77
ENTHD1	0.769
TRPC7	0.765
TMPRSS6	0.765

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNNT2	-0.413
SOHLH1	-0.357
SLC17A7	-0.35
NXPH3	-0.322
TBR1	-0.318
NEUROD2	-0.316
SYTL2	-0.291
RNF182	-0.29
NTNG2	-0.286
EMX1	-0.283

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Target
DB00514	Dextromethorphan	Small Molecule	125-71-3	Approved	Target
DB00674	Galantamine	Small Molecule	357-70-0	Approved	Target
DB00848	Levamisole	Small Molecule	14769-73-4	Approved\|Investigational\|Withdrawn	Target
DB00898	Ethanol	Small Molecule	64-17-5	Approved	Target
DB01090	Pentolinium	Small Molecule	144-44-5	Approved	Target
DB01156	Bupropion	Small Molecule	34911-55-2	Approved	Target
DB01227	Levomethadyl Acetate	Small Molecule	1477-40-3	Approved\|Investigational	Target
DB01273	Varenicline	Small Molecule	249296-44-4	Approved\|Investigational	Target
DB07720	Epibatidine	Small Molecule	140111-52-0	Experimental	Target
DB09028	Cytisine	Small Molecule	485-35-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C482518	1,2-bis-N-cytisinylethane	"1,2-bis-N-cytisinylethane promotes the reaction [CHRNA3 protein binds to CHRNB2 protein]"	16273122
C482518	1,2-bis-N-cytisinylethane	"1,2-bis-N-cytisinylethane promotes the reaction [CHRNA3 protein binds to CHRNB2 protein binds to CHRNB4 protein]"	16273122
C482518	1,2-bis-N-cytisinylethane	"1,2-bis-N-cytisinylethane results in increased localization of [CHRNA3 protein binds to CHRNB2 protein]"	16273122
C482518	1,2-bis-N-cytisinylethane	"1,2-bis-N-cytisinylethane results in increased localization of [CHRNA3 protein binds to CHRNB2 protein binds to CHRNB4 protein]"	16273122
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of CHRNA3 mRNA"	19162173
C569671	2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane	"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]"	21942635
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRNA3 mRNA"	25510870
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHRNA3 mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRNA3 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRNA3 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRNA3 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRNA3 mRNA"	25510870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C041594	4-nonylphenol	4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C041594	4-nonylphenol	4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C080417	4-octylphenol	4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
D000109	Acetylcholine	4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]	15885267\|1693198
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	16931985
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
D000109	Acetylcholine	Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D000109	Acetylcholine	mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D000109	Acetylcholine	Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D000109	Acetylcholine	Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D000109	Acetylcholine	Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D000109	Acetylcholine	Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein alternative form]	16569710
D000109	Acetylcholine	Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]	7808438
D000109	Acetylcholine	Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	7808438
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]	15885267
D000109	Acetylcholine	[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]	12130716
D000109	Acetylcholine	Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D000109	Acetylcholine	Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D000109	Acetylcholine	Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]	7808438
D000109	Acetylcholine	Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]	7808438
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]	7891159
D000109	Acetylcholine	Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	7891159
D000109	Acetylcholine	Flufenamic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	7891159
D000109	Acetylcholine	Flufenamic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D000109	Acetylcholine	Flufenamic Acid promotes the reaction [Magnesium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]]	7891159
D000109	Acetylcholine	Magnesium promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D000109	Acetylcholine	Niflumic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	7891159
D000109	Acetylcholine	Niflumic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CHRNA3 mRNA	22100608
D000447	Aldehydes	Aldehydes results in increased expression of CHRNA3 mRNA	25014914
C098872	alpha-conotoxin MII	alpha-conotoxin MII results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]	18450646
D000639	Amitriptyline	Amitriptyline results in decreased expression of CHRNA3 mRNA	22341215
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CHRNA3 mRNA	16483693
D000691	Anabasine	Anabasine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CHRNA3 mRNA	24449571
D001279	Atracurium	Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D001279	Atracurium	Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C547126	AZM551248	AZM551248 results in increased expression of CHRNA3 mRNA	22323515
C487081	belinostat	belinostat results in increased expression of CHRNA3 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
D004958	Estradiol	Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D004958	Estradiol	Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C006780	bisphenol A	bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C006780	bisphenol A	bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C006780	bisphenol A	bisphenol A results in decreased expression of CHRNA3 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of CHRNA3 mRNA	26079696
D002217	Carbachol	Carbachol inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D002217	Carbachol	Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein]	15615518
D002220	Carbamazepine	Carbamazepine affects the expression of CHRNA3 mRNA	25979313
D012721	Carbaryl	Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]	14644616
D012721	Carbaryl	Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	14644616
D002245	Carbon Dioxide	Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]	28235547
D002245	Carbon Dioxide	[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein	28235547
C101584	cisatracurium	cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
C101584	cisatracurium	cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D003042	Cocaine	Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	10336510
C004712	cytisine	cytisine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C004712	cytisine	cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
C033019	decamethonium	decamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D003976	Diazinon	Diazinon results in decreased expression of CHRNA3 mRNA	17452286\|1881221
D004026	Dieldrin	Dieldrin results in decreased expression of CHRNA3 mRNA	18812211
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine binds to and affects the activity of [CHRNA3 protein binds to CHRNB2 protein]	12604094
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA3 protein	12511591
D004079	Dihydro-beta-Erythroidine	Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]	16601104
D004246	Dimethylphenylpiperazinium Iodide	Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D004246	Dimethylphenylpiperazinium Iodide	Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
D004298	Dopamine	CHRNA3 protein results in increased secretion of Dopamine	15542623
C118739	entinostat	entinostat results in increased expression of CHRNA3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
C082748	epibatidine	Carbachol inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	cytisine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	decamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]	12770692
C082748	epibatidine	Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Nicotine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C082748	epibatidine	"2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]"	21942635
C082748	epibatidine	[CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine	9454827
C082748	epibatidine	epibatidine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	22060139
C082748	epibatidine	epibatidine binds to CHRNA3 protein	17203487
C082748	epibatidine	Tretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]	17203487
C082748	epibatidine	[CHRNA3 protein binds to CHRNB4 protein] which binds to epibatidine	9687574
C082748	epibatidine	epibatidine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
C082748	epibatidine	epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]	15615518
C036251	EPTC	EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]	14644616
C036251	EPTC	EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	14644616
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
C052034	fenoxycarb	fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]	14644616
C052034	fenoxycarb	fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	14644616
D005439	Flufenamic Acid	Flufenamic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	7891159
D005439	Flufenamic Acid	Flufenamic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D005439	Flufenamic Acid	Flufenamic Acid promotes the reaction [Magnesium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]]	7891159
D005492	Folic Acid	Folic Acid results in decreased expression of CHRNA3 mRNA	25006883
D004397	Fonofos	Fonofos results in increased methylation of CHRNA3 promoter	22847954
D018738	Hexamethonium	Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D018738	Hexamethonium	Hexamethonium results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
C110702	IEM 1460	IEM 1460 results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	19145339
C082359	imidacloprid	CHRNA3 protein mutant form results in decreased susceptibility to imidacloprid	15937112
D008274	Magnesium	Flufenamic Acid promotes the reaction [Magnesium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]]	7891159
D008274	Magnesium	Magnesium promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
D008464	Mecamylamine	Mecamylamine binds to and results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	20100906
D008464	Mecamylamine	Mecamylamine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D008627	Mercuric Chloride	[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]	12130716
C054634	methyllycaconitine	methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
C054634	methyllycaconitine	CHRNA3 protein affects the susceptibility to methyllycaconitine	19098233
C054634	methyllycaconitine	methyllycaconitine binds to and results in decreased activity of CHRNA3 protein	12604094
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium affects the expression of CHRNA3 mRNA	12710931
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of CHRNA3 mRNA	29191790
C049430	mivacurium	mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
C049430	mivacurium	mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C524978	N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline	"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]"	17873105
D009532	Nickel	Nickel results in decreased expression of CHRNA3 mRNA	18812211
D009538	Nicotine	Nicotine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D009538	Nicotine	CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]	18450646
D009538	Nicotine	CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]	18450646
D009538	Nicotine	CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]	18450646
D009538	Nicotine	CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]	18450646
D009538	Nicotine	Nicotine results in decreased expression of CHRNA3 mRNA	12628473
D009538	Nicotine	Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]	9454827
D009538	Nicotine	CHRNA3 protein affects the susceptibility to Nicotine	15275829
D009538	Nicotine	Nicotine results in increased expression of CHRNA3 mRNA	17135361
D009538	Nicotine	Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	10336510
D009538	Nicotine	Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
D009538	Nicotine	Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	15615518
D009538	Nicotine	Nicotine results in increased activity of CHRNA3 protein	19483072
D009538	Nicotine	Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]	10336510
D009538	Nicotine	Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]	28235547
D009544	Niflumic Acid	Niflumic Acid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	7891159
D009544	Niflumic Acid	Niflumic Acid promotes the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	7891159
C008655	N'-nitrosonornicotine	N'-nitrosonornicotine binds to CHRNA3 protein	16835749\|1838573
D010100	Oxygen	Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]	28235547
D010100	Oxygen	[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein	28235547
D010197	Pancuronium	Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D010197	Pancuronium	Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
D010278	Parathion	Parathion results in increased methylation of CHRNA3 promoter	22847954
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CHRNA3 mRNA"	25510870
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CHRNA3 mRNA	26705709
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether affects the expression of CHRNA3 mRNA	27294297
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CHRNA3 mRNA	27294297
C046012	pentanal	pentanal results in increased expression of CHRNA3 mRNA	26079696
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of CHRNA3 mRNA	26272509
D010936	Plant Extracts	Plant Extracts results in decreased expression of CHRNA3 mRNA	23557933
C005556	propionaldehyde	propionaldehyde results in increased expression of CHRNA3 mRNA	26079696
C061870	rocuronium	rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
C061870	rocuronium	rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D012524	Sarin	Sarin results in decreased expression of CHRNA3 mRNA	19522546
D012715	Sesame Oil	Sesame Oil results in increased expression of CHRNA3 mRNA	29191790
D013629	Tamoxifen	4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]	11711029
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]	11711029
C012568	terbufos	terbufos results in increased methylation of CHRNA3 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CHRNA3 mRNA	19465110
D013750	Tetrachloroethylene	Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D013750	Tetrachloroethylene	Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D019284	Thapsigargin	Thapsigargin results in decreased expression of CHRNA3 mRNA	22378314
D014028	Tobacco Smoke Pollution	CHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]	18450646
D014028	Tobacco Smoke Pollution	CHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]	18450646
D014028	Tobacco Smoke Pollution	CHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]	18450646
D014028	Tobacco Smoke Pollution	CHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]	18450646
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CHRNA3 protein	26746805
D014050	Toluene	Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D014050	Toluene	Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	15885267
D014212	Tretinoin	Tretinoin results in increased expression of CHRNA3 mRNA	21934132
D014212	Tretinoin	Tretinoin promotes the reaction [epibatidine binds to CHRNA3 protein]	17203487
D014212	Tretinoin	Tretinoin results in increased expression of CHRNA3 mRNA	17203487
D014212	Tretinoin	Tretinoin results in increased expression of CHRNA3 protein	17203487
D014212	Tretinoin	Tretinoin results in increased expression of CHRNA3 mRNA	20488242
C012589	trichostatin A	trichostatin A results in increased expression of CHRNA3 mRNA	24935251
D014403	Tubocurarine	Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]	12770692
D014403	Tubocurarine	Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D014403	Tubocurarine	Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D014403	Tubocurarine	Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]	7808438
D014403	Tubocurarine	Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]	7808438
D014403	Tubocurarine	Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]	9687574
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CHRNA3 mRNA	25979313\|2607246
D014635	Valproic Acid	Valproic Acid results in increased expression of CHRNA3 mRNA	24935251\|2627250
D014635	Valproic Acid	Valproic Acid results in increased methylation of CHRNA3 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of CHRNA3 mRNA	26072468
D000068580	Varenicline	Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]	16766716
D000068580	Varenicline	Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]	16766716
D014673	Vecuronium Bromide	Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]	16931985
D014673	Vecuronium Bromide	Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]	16931985
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of CHRNA3 gene	25560391
C111237	vorinostat	vorinostat results in decreased expression of CHRNA3 mRNA	27188386
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of CHRNA3 mRNA	27215404
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of CHRNA3 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005230	extracellular ligand-gated ion channel activity	CONTRIBUTES_TO	IBA	21873635
GO:0005515	protein binding	-	IPI	27344019
GO:0015276	ligand-gated ion channel activity	-	TAS	20438829
GO:0015464	acetylcholine receptor activity	CONTRIBUTES_TO	IBA	21873635
GO:0015464	acetylcholine receptor activity	-	IDA	8906617
GO:0022848	acetylcholine-gated cation-selective channel activity	-	IDA	8906617
GO:0022848	acetylcholine-gated cation-selective channel activity	-	ISS	-
GO:0022848	acetylcholine-gated cation-selective channel activity	-	TAS	20438829
GO:0042166	acetylcholine binding	CONTRIBUTES_TO	IBA	21873635
GO:0042166	acetylcholine binding	-	IC	8906617

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006811	ion transport	-	NAS	8906617
GO:0006940	regulation of smooth muscle contraction	-	ISS	-
GO:0007165	signal transduction	-	IBA	21873635
GO:0007165	signal transduction	-	IDA	8906617
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	-	ISS	-
GO:0007210	serotonin receptor signaling pathway	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007271	synaptic transmission, cholinergic	-	IBA	21873635
GO:0007271	synaptic transmission, cholinergic	-	ISS	-
GO:0007274	neuromuscular synaptic transmission	-	IBA	21873635
GO:0007399	nervous system development	-	IMP	11450844
GO:0007626	locomotory behavior	-	ISS	-
GO:0014056	regulation of acetylcholine secretion, neurotransmission	-	ISS	-
GO:0034220	ion transmembrane transport	-	IBA	21873635
GO:0034220	ion transmembrane transport	-	IEA	-
GO:0035094	response to nicotine	-	IBA	21873635
GO:0035095	behavioral response to nicotine	-	IMP	18227835
GO:0042391	regulation of membrane potential	-	IBA	21873635
GO:0042391	regulation of membrane potential	-	ISS	-
GO:0048814	regulation of dendrite morphogenesis	-	ISS	-
GO:0050877	nervous system process	-	IBA	21873635
GO:0060079	excitatory postsynaptic potential	-	ISS	-
GO:0060084	synaptic transmission involved in micturition	-	IMP	11450844
GO:0095500	acetylcholine receptor signaling pathway	-	ISS	-
GO:1905144	response to acetylcholine	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005892	acetylcholine-gated channel complex	-	IBA	21873635
GO:0005892	acetylcholine-gated channel complex	-	IDA	8906617
GO:0014069	postsynaptic density	-	ISS	-
GO:0016021	integral component of membrane	-	NAS	8906617
GO:0030054	cell junction	-	IEA	-
GO:0030425	dendrite	-	ISS	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0043025	neuronal cell body	-	ISS	-
GO:0044853	plasma membrane raft	-	ISS	-
GO:0045202	synapse	-	IBA	21873635
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-181431	Acetylcholine binding and downstream events	TAS
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	TAS
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	TAS
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	TAS
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	TAS
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	TAS
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20656943	Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. (2010 Dec 15)	Pillai SG	Am J Respir Crit Care Med
22837378	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012 Oct 1)	Wilk JB	Am J Respir Crit Care Med
18227835	Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. (2008 Apr)	Berrettini W	Mol Psychiatry
20840187	Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. (2010 Nov)	Johnson EO	Addiction
27015805	Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. (2016 Mar)	Pilling LC	Aging (Albany NY)
23011884	Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations. (2013 Apr 15)	Tekpli X	Int J Cancer
19491260	Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. (2009 Jun 15)	Wu C	Cancer Res
21268243	Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. (2011 Apr)	Sarginson JE	Am J Med Genet B Neuropsychiatr Genet
23689675	Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. (2013 Oct)	Nees F	Neuropsychopharmacology
29621993	Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women. (2018 Apr 5)	Tomaz PRX	BMC Med Genet
28978081	Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. (2017 Sep 15)	Bordas A	Oncotarget
28369244	Targeted sequencing of chromosome 15q25 identified novel variants associated with risk of lung cancer and smoking behavior in Chinese. (2017 May 1)	Cheng Y	Carcinogenesis
21045689	Nicotinic acetylcholine receptors and predisposition to lung cancer. (2011 Jan)	Tournier JM	Curr Opin Oncol
28583088	Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. (2017 Jun 5)	Zhang B	BMC Genomics
18519524	Variants in nicotinic receptors and risk for nicotine dependence. (2008 Sep)	Bierut LJ	Am J Psychiatry
22046326	'Smoking genes': a genetic association study. (2011)	Verde Z	PLoS One
18414406	Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. (2009 May)	Wang JC	Mol Psychiatry
19443489	Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. (2009 Aug 15)	Wang JC	Hum Mol Genet
21555077	Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula. (2011 May 12)	Frahm S	Neuron
25777141	High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study. (2015 Apr)	Winslow UC	Int J Epidemiol
20700436	Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. (2010 Aug 5)	Saccone NL	PLoS Genet
26831765	Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis. (2016 Feb 1)	Qu X	Sci Rep
27613936	High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)	Fiatal S	Nicotine Tob Res
25656608	CHRNA3 genetic polymorphism and the risk of lung cancer in the Chinese Han smoking population. (2015 Jul)	Zhou W	Tumour Biol
24062692	Nicotinic acetylcholine receptors mediate lung cancer growth. (2013)	Improgo MR	Front Physiol
20886544	Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. (2010 Dec 5)	Winterer G	Am J Med Genet B Neuropsychiatr Genet
24065931	The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers. (2013)	Robinson JD	Front Psychiatry
19300482	A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. (2009 Mar)	Pillai SG	PLoS Genet
23397474	Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. (2012 Dec)	Li Z	Transl Oncol
23604333	The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism. (2013 Sep)	Petrovsky N	Psychopharmacology (Berl)
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