Gene: CHRNA5

1138
LNCR2
cholinergic receptor nicotinic alpha 5 subunit
protein-coding
15q25.1
Ensembl:ENSG00000169684 MIM:118505 Vega:OTTHUMG00000143858 UniprotKB:P30532
NG_023328.1
PubMed|SNP Mapped
CD|OD|ND|AD
214   
7.307e-1 (AD)  6.390e-5 (ND)   (Frontal_Cortex)
7.479e-1 (AD)  1.000e-12 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16969968chr15:78590583 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs951266chr15:78586199 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs569207chr15:78580777 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs680244chr15:78578946 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19696491chr15:78857124CHRNA51.900e-13Smoking27651444
cg22563815chr15:78856949CHRNA58.800e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHORDC10.574
ZNF4730.544
P4HA20.535
JMJD60.532
STIP10.511
SESN20.51
DNAJB40.5
LRIF10.499
MANF0.492
CEBPG0.491

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCGB2B2-0.319
MYLK2-0.309
ACCS-0.306
PBLD-0.295
SNX22-0.292
DEGS2-0.29
TSPAN32-0.286
CCNB3-0.283
SLC38A5-0.282
TTC16-0.27

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]"18450646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]"18450646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]"18450646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]"18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA5 mRNA"27188386
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]"18450646
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]"18450646
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]"18450646
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]"18450646
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CHRNA5 mRNA29067470
D000109AcetylcholineAcetylcholine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CHRNA5 protein20106945
C098872alpha-conotoxin MIIalpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
C098872alpha-conotoxin MIIalpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
C098872alpha-conotoxin MIIalpha-conotoxin MII inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
C098872alpha-conotoxin MIIalpha-conotoxin MII inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]8388298
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA5 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CHRNA5 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHRNA5 mRNA26238291
C004873beta-erythroidinebeta-erythroidine binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D004958EstradiolEstradiol results in increased expression of CHRNA5 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of CHRNA5 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of CHRNA5 mRNA26191083
D002217CarbacholCarbachol binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CHRNA5 mRNA18812211
D003042CocaineCHRNA5 gene polymorphism results in decreased susceptibility to Cocaine18519132
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CHRNA5 mRNA20971185
D003375CoumestrolCoumestrol results in increased expression of CHRNA5 mRNA19167446
C004712cytisinecytisine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CHRNA5 mRNA23914054
C033019decamethoniumdecamethonium binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D003703DemecolcineDemecolcine results in decreased expression of CHRNA5 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CHRNA5 mRNA]27941970
D003976DiazinonDiazinon results in decreased expression of CHRNA5 mRNA18812211
D004026DieldrinDieldrin results in decreased expression of CHRNA5 mRNA18812211
D004246Dimethylphenylpiperazinium IodideDimethylphenylpiperazinium Iodide binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C082748epibatidineepibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D000431EthanolEthanol affects the expression of CHRNA5 mRNA20438829
D000431EthanolEthanol affects the expression of CHRNA5 mRNA26730594
D005419FlavonoidsFlavonoids results in decreased expression of CHRNA5 mRNA18035473
D005473FluoxetineFluoxetine results in decreased expression of CHRNA5 mRNA21820738
C039281furanfuran results in increased methylation of CHRNA5 gene22079235
C015542gaboxadolgaboxadol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]8388298
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA5 mRNA21782745
C081021Go 6976Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
C081021Go 6976Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
C081021Go 6976Go 6976 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
C081021Go 6976Go 6976 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D018738HexamethoniumHexamethonium binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
C544151jinfukangjinfukang results in decreased expression of CHRNA5 mRNA27392435
C063302KN 62KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
C063302KN 62KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
C063302KN 62KN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
C063302KN 62KN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
C054474manumycinmanumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
C054474manumycinmanumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
C054474manumycinmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
C054474manumycinmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D008464MecamylamineMecamylamine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D008727MethotrexateMethotrexate affects the expression of CHRNA5 mRNA18502557
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA5 mRNA21782745
C054634methyllycaconitineCHRNA5 protein affects the susceptibility to methyllycaconitine19098233
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CHRNA5 mRNA26011545
D009118MuscimolMuscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein]8388298
D009538NicotineNicotine binds to and results in increased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D009538Nicotine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]"18450646
D009538Nicotine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]"18450646
D009538Nicotine4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538Nicotine4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538Nicotine"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]"18450646
D009538Nicotine"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]"18450646
D009538Nicotinealpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538Nicotinealpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineCHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538NicotineCHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineCHRNA5 gene polymorphism results in increased susceptibility to Nicotine18519132
D009538NicotineCHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]24793809
D009538NicotineCHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]24793809
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineGo 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538NicotineGo 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineKN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538NicotineKN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538Nicotinemanumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]18450646
D009538Nicotinemanumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]18450646
D009538NicotineNicotine results in decreased expression of CHRNA5 mRNA12628473
D009538NicotineNicotine results in increased expression of CHRNA5 mRNA18450646
D009538NicotineNicotine results in increased expression of CHRNA5 protein18450646|2479380
D009538NicotineCHRNA5 gene polymorphism affects the susceptibility to Nicotine9495872
C008655N'-nitrosonornicotineN'-nitrosonornicotine binds to CHRNA5 protein18385738
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CHRNA5 mRNA20971185
D010269ParaquatParaquat affects the expression of CHRNA5 mRNA18198484
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the expression of CHRNA5 mRNA27294297
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CHRNA5 mRNA26272509
C108326pozaniclineCHRNA5 protein affects the susceptibility to pozanicline19481067
C108326pozaniclinepozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNA5 protein binds to CHRNB2 protein]19481067
D011374ProgesteroneProgesterone results in increased expression of CHRNA5 protein19220484
D011374ProgesteroneProgesterone results in increased expression of CHRNA5 mRNA19220484
C059514resveratrolresveratrol affects the expression of CHRNA5 mRNA27070252
D019284ThapsigarginThapsigargin results in decreased expression of CHRNA5 mRNA22378314
D014028Tobacco Smoke Pollution"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]"18450646
D014028Tobacco Smoke Pollution"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]"18450646
D014028Tobacco Smoke Pollution4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke Pollution4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke Pollution"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]"18450646
D014028Tobacco Smoke Pollution"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]"18450646
D014028Tobacco Smoke Pollutionalpha-conotoxin MII inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke Pollutionalpha-conotoxin MII inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionCHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke PollutionCHRNA3 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionGo 6976 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke PollutionGo 6976 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionKN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke PollutionKN 62 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke Pollutionmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]18450646
D014028Tobacco Smoke Pollutionmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionMecamylamine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein]18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA5 mRNA18450646|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA5 protein18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHRNA5 protein26746805
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHRNA5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CHRNA5 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of CHRNA5 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CHRNA5 mRNA"26179874
D014403TubocurarineTubocurarine binds to and results in decreased activity of [CHRNA2 protein binds to CHRNA5 protein binds to CHRNB2 protein]10908297
D014415TunicamycinTunicamycin results in decreased expression of CHRNA5 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CHRNA5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CHRNA5 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of CHRNA5 mRNA24896083
D014635Valproic AcidValproic Acid results in increased expression of CHRNA5 mRNA15901671
C111237vorinostatvorinostat results in increased expression of CHRNA5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI8663494  27344019  
GO:0015276ligand-gated ion channel activity-TAS20438829  
GO:0015464acetylcholine receptor activityCONTRIBUTES_TOIBA21873635  
GO:0015464acetylcholine receptor activity-IDA1542648  
GO:0022848acetylcholine-gated cation-selective channel activity-NAS1542648  
GO:0022848acetylcholine-gated cation-selective channel activity-TAS20438829  
GO:0042166acetylcholine bindingCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-NAS9009220  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS9009220  
GO:0007271synaptic transmission, cholinergic-IBA21873635  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0035094response to nicotine-IBA21873635  
GO:0035095behavioral response to nicotine-IMP18227835  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IBA21873635  
GO:0005892acetylcholine-gated channel complex-IC1542648  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622323Presynaptic nicotinic acetylcholine receptorsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26762739Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (2016 Jan)Liu YJ Thorac Oncol
26693074CHRNA5 polymorphisms and risk of lung cancer in Chinese Han smokers. (2015)Huang CYAm J Cancer Res
27344179Associations between smoking behavior-related alleles and the risk of melanoma. (2016 Jul 26)Wu WOncotarget
24082085Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. (2013 Oct 15)Gorlich AProc Natl Acad Sci U S A
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