Gene info: ID 114088

Gene: TRIM9

GENE ID: 114088

Synonyms: RNF91|SPRING

Description: tripartite motif containing 9

Gene type: protein-coding

Location: 14q22.1

dbXrefs: Ensembl:ENSG00000100505 MIM:606555 Vega:OTTHUMG00000140291 UniprotKB:Q9C026

RefSeq: NC_000014.9

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.136e-1 (AD) 2.005e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs8009082	chr14:51032626 (GRCh38.p7)	C>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14837480	chr14:51463130	TRIM9	Gene body	1.273e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TCERG1	0.922
PIAS2	0.906
XPO5	0.904
MRPS25	0.899
PPIL2	0.898
CCPG1	0.895
TNRC6A	0.894
CELF1	0.893
SUGP2	0.892
SUDS3	0.89

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.658
OR4F29	-0.604
SH2D1A	-0.305
CCDC102A	-0.284
ANXA13	-0.284
KLRC2	-0.278
SPINK8	-0.26
CSAG1	-0.26
RHOD	-0.259
NKX6-1	-0.258

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of TRIM9 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TRIM9 gene	27153756
D000393	Air Pollutants	Air Pollutants results in decreased expression of TRIM9 mRNA	23649983
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TRIM9 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of TRIM9 gene	25304211
C006780	bisphenol A	bisphenol A affects the expression of TRIM9 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of TRIM9 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of TRIM9 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TRIM9 mRNA	26472689
D002220	Carbamazepine	Carbamazepine affects the expression of TRIM9 mRNA	25979313
D003300	Copper	Copper deficiency results in increased expression of TRIM9 mRNA	26033743
D016572	Cyclosporine	Cyclosporine results in increased expression of TRIM9 mRNA	20106945
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of TRIM9 mRNA	26033743
D004397	Fonofos	Fonofos results in increased methylation of TRIM9 promoter	22847954
C051890	irinotecan	irinotecan analog results in increased expression of TRIM9 mRNA	18927307
D009532	Nickel	Nickel results in decreased expression of TRIM9 mRNA	24768652
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of TRIM9 mRNA	26272509
D010278	Parathion	Parathion results in increased methylation of TRIM9 promoter	22847954
D010634	Phenobarbital	Phenobarbital results in increased expression of TRIM9 mRNA	19084549
D010936	Plant Extracts	Plant Extracts results in decreased expression of TRIM9 mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TRIM9 mRNA	23608068
C012568	terbufos	terbufos results in increased methylation of TRIM9 promoter	22847954
D013849	Thimerosal	Thimerosal results in decreased expression of TRIM9 mRNA	27188386
C024746	tobacco tar	tobacco tar results in decreased expression of TRIM9 mRNA	19559774
D014212	Tretinoin	Tretinoin results in increased expression of TRIM9 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of TRIM9 mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRIM9 mRNA"	26179874
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of TRIM9 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TRIM9 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of TRIM9 gene	25560391
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM9 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of TRIM9 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000149	SNARE binding	-	IEA	-
GO:0004842	ubiquitin-protein transferase activity	-	IDA	20085810
GO:0005515	protein binding	-	IPI	16189514 25416956 26871637
GO:0008270	zinc ion binding	-	IEA	-
GO:0019904	protein domain specific binding	-	IPI	22084112
GO:0042803	protein homodimerization activity	-	IPI	11331580

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0016079	synaptic vesicle exocytosis	-	IEA	-
GO:0016567	protein ubiquitination	-	IEA	-
GO:0035544	negative regulation of SNARE complex assembly	-	IEA	-
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	IDA	20085810
GO:0045955	negative regulation of calcium ion-dependent exocytosis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	11331580 20085810
GO:0005829	cytosol	-	IDA	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0008021	synaptic vesicle	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030425	dendrite	-	IDA	20085810

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal