Gene: ZNF618

114991
FP13169|NEDD10
zinc finger protein 618
protein-coding
9q32
Ensembl:ENSG00000157657 MIM:617077 Vega:OTTHUMG00000020532 UniprotKB:Q5T7W0
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.036e-1 (AD)  7.938e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10513224chr9:113979159 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC280.737
SYNE20.699
EP3000.697
ZNF8080.694
PEAK10.677
ZNF6600.66
ZBTB400.652
KAT6B0.649
CNOT60.649
TAF40.643

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDND2-0.341
OR4F5-0.338
OR4F29-0.315
GHRH-0.249
TMEM114-0.243
LAIR2-0.237
CLPSL1-0.235
NANOGNB-0.232
UTS2-0.229
CAPSL-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of ZNF618 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ZNF618 mRNA"25614096
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of ZNF618 mRNA"23829299
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ZNF618 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF618 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF618 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ZNF618 mRNA29067470
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZNF618 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNF618 mRNA20064835|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZNF618 mRNA"20018196|2038263
C044887beta-methylcholinebeta-methylcholine affects the expression of ZNF618 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ZNF618 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZNF618 mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ZNF618 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of ZNF618 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased methylation of ZNF618 promoter27989131
D002945CisplatinCisplatin results in increased expression of ZNF618 mRNA27392435
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZNF618 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZNF618 mRNA24796395|2675264
D007854LeadLead results in decreased expression of ZNF618 mRNA19921347
D008558MelphalanMelphalan results in decreased expression of ZNF618 mRNA22363485
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ZNF618 mRNA20971185
C410127PCB 180PCB 180 results in increased expression of ZNF618 mRNA23829299
D010416PentachlorophenolPentachlorophenol results in decreased expression of ZNF618 mRNA24642059
C005556propionaldehydepropionaldehyde results in decreased expression of ZNF618 mRNA26079696
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZNF618 mRNA25613284
C024746tobacco tartobacco tar results in decreased expression of ZNF618 mRNA19559774
D014212TretinoinTretinoin results in increased expression of ZNF618 mRNA20488242
D014415TunicamycinTunicamycin results in decreased expression of ZNF618 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF618 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZNF618 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF618 mRNA19101580|2317975
C111237vorinostatvorinostat results in decreased expression of ZNF618 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal