Gene: ADCY9

115
AC9|ACIX
adenylate cyclase 9
protein-coding
16p13.3
Ensembl:ENSG00000162104 MIM:603302 Vega:OTTHUMG00000177612 UniprotKB:O60503
NG_011434.1
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.437e-1 (AD)  5.578e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9927767chr16:4118169 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10775349chr16:4029822 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01207684chr16:4103167ADCY98.400e-10Smoking27651444
cg06223834chr16:4103161ADCY91.900e-10Smoking28686328
cg01207684chr16:4103167ADCY91.020e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF1420.917
PLXNA20.915
TRIO0.912
WIPF20.911
LUZP10.909
RAI10.907
MECP20.907
CHERP0.907
ANKRD110.906
ZNF7460.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.502
OR4F29-0.454
CTNNA3-0.436
MYL3-0.435
KLRC3-0.418
COPZ2-0.403
SH2D1A-0.395
KLRC2-0.381
LRRCC1-0.381
KLRF1-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADCY9 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ADCY9 mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADCY9 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY9 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ADCY9 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ADCY9 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of ADCY9 mRNA]21233418
D003913DextroamphetamineDextroamphetamine results in increased expression of ADCY9 mRNA12558987
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ADCY9 mRNA24449571
D001151ArsenicArsenic affects the methylation of ADCY9 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ADCY9 mRNA15761015
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADCY9 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADCY9 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADCY9 mRNA"19150397|2623829
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ADCY9 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ADCY9 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ADCY9 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ADCY9 mRNA25181051|2909715
C006780bisphenol Abisphenol A results in increased methylation of ADCY9 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ADCY9 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of ADCY9 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADCY9 mRNA23741332
D002220CarbamazepineCarbamazepine affects the expression of ADCY9 mRNA24752500
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein]19922557
D004390ChlorpyrifosChlorpyrifos results in increased expression of ADCY9 mRNA17452286
D003471CuprizoneCuprizone results in decreased expression of ADCY9 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of ADCY9 mRNA15713895
D016572CyclosporineCyclosporine results in decreased expression of ADCY9 mRNA20106945|2556210
D003976DiazinonDiazinon results in decreased methylation of ADCY9 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADCY9 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ADCY9 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of ADCY9 mRNA24752500
D004008DiclofenacDiclofenac results in decreased expression of ADCY9 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of ADCY9 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of ADCY9 mRNA18042831
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of ADCY9 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of ADCY9 mRNA21233418
D000431EthanolEthanol results in increased expression of ADCY9 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADCY9 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY9 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADCY9 mRNA29097150
D005472FluorouracilFluorouracil results in decreased expression of ADCY9 mRNA19219653
D005485FlutamideFlutamide results in decreased expression of ADCY9 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of ADCY9 mRNA14756816
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of ADCY9 mRNA22634610
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ADCY9 mRNA27392435
D007649KetamineKetamine results in increased expression of ADCY9 mRNA20080153
D007854LeadLead affects the expression of ADCY9 mRNA28903495
C045463leflunomideleflunomide results in increased expression of ADCY9 mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADCY9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADCY9 mRNA"25554681|2562005
D000073878Palm OilPalm Oil results in decreased expression of ADCY9 mRNA18042831
C016030pantogabpantogab results in decreased expression of ADCY9 mRNA17379144
C006253pirinixic acidpirinixic acid results in decreased expression of ADCY9 mRNA15375163
C045950propiconazolepropiconazole results in decreased expression of ADCY9 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADCY9 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of ADCY9 mRNA22610192
D012402RotenoneRotenone results in increased expression of ADCY9 mRNA19013527
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADCY9 mRNA25895662
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein]19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein19922557
C004648testosterone enanthatetestosterone enanthate affects the expression of ADCY9 mRNA25603467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADCY9 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADCY9 mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY9 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ADCY9 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADCY9 mRNA21215274
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY9 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ADCY9 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ADCY9 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADCY9 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ADCY9 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY9 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ADCY9 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ADCY9 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ADCY9 mRNA17292431
D014638VanadatesVanadates results in increased expression of ADCY9 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-IDA9628827  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003091renal water homeostasis-TAS-  
GO:0006171cAMP biosynthetic process-IDA9628827  10987815  
GO:0007165signal transduction-TAS9628827  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA9628827  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS-  
GO:0071377cellular response to glucagon stimulus-TAS-  
GO:0071880adenylate cyclase-activating adrenergic receptor signaling pathway-IMP9628827  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA10987815  
GO:0016021integral component of membrane-IDA9628827  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04916Melanogenesis
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05110Vibrio cholerae infection
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-111931PKA-mediated phosphorylation of CREBTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163359Glucagon signaling in metabolic regulationTAS
R-HSA-163615PKA activationTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-164378PKA activation in glucagon signallingTAS
R-HSA-170660Adenylate cyclase activating pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977443GABA receptor activationIEA
R-HSA-977444GABA B receptor activationTAS
R-HSA-977444GABA B receptor activationIEA
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-991365Activation of GABAB receptorsIEA
R-HSA-997269Inhibition of adenylate cyclase pathwayTAS
R-HSA-997269Inhibition of adenylate cyclase pathwayIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25555412Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. (2015 Sep)Weng JTComput Biol Med