Gene: ARAP1

116985
CENTD2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
protein-coding
11q13.4
Ensembl:ENSG00000186635 MIM:606646 Vega:OTTHUMG00000157102 UniprotKB:Q96P48
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.668e-1 (AD)  1.246e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7120605chr11:72733570 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21881364chr11:72438004ARAP1Gene body5.842e-4Alcohol use disorders26763658
cg12298445chr11:72438603ARAP12.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC12A90.864
RNPEPL10.823
TYK20.821
EHMT10.813
ABL10.812
UNC5B0.812
CLN30.81
TTC7A0.81
DNM20.809
ARHGEF10.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.609
OR4F29-0.583
HDC-0.288
CRH-0.225
C22orf42-0.216
NTS-0.207
FOXB1-0.205
ODAM-0.205
SIM1-0.201
OTP-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of ARAP1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARAP1 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ARAP1 mRNA"23195993
D001151ArsenicArsenic affects the methylation of ARAP1 gene25304211
D001280AtrazineAtrazine results in increased expression of ARAP1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of ARAP1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARAP1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ARAP1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of ARAP1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of ARAP1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ARAP1 mRNA25181051
D016572CyclosporineCyclosporine results in decreased methylation of ARAP1 promoter27989131
C014347decitabinedecitabine results in decreased methylation of ARAP1 gene27923600
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ARAP1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ARAP1 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ARAP1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ARAP1 mRNA]19850644
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of ARAP1 gene23968726
C118739entinostatentinostat results in increased expression of ARAP1 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ARAP1 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of ARAP1 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ARAP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARAP1 mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ARAP1 mRNA23649840
D008774MethylphenidateMethylphenidate results in decreased expression of ARAP1 mRNA22470460
D009532NickelNickel results in decreased expression of ARAP1 mRNA23195993
D052638Particulate MatterParticulate Matter results in decreased expression of ARAP1 mRNA28341207
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ARAP1 protein26879310
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of ARAP1 gene23968726
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ARAP1 mRNA27029645
C010327salinomycinsalinomycin results in decreased expression of ARAP1 mRNA19682730
D013853ThioacetamideThioacetamide results in decreased expression of ARAP1 mRNA23411599
C057693troglitazonetroglitazone results in decreased expression of ARAP1 mRNA28973697
D014520UrethaneUrethane results in decreased expression of ARAP1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ARAP1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ARAP1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARAP1 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of ARAP1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA11804590  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI15607035  16169070  18165900  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-IDA11804589  
GO:0031702type 1 angiotensin receptor binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001921positive regulation of receptor recycling-IEA-  
GO:0007165signal transduction-IEA-  
GO:0008360regulation of cell shape-IMP11804590  
GO:0030037actin filament reorganization involved in cell cycle-TAS11804590  
GO:0043547positive regulation of GTPase activity-IDA11804590  
GO:0045742positive regulation of epidermal growth factor receptor signaling pathway-TAS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051270regulation of cellular component movement-IMP11804590  
GO:0051491positive regulation of filopodium assembly-IMP11804590  
GO:0051497negative regulation of stress fiber assembly-IMP11804590  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA11804590  
GO:0005802trans-Golgi network-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849469PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1TAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23577190PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)Suzuki TPLoS One