Gene: ADCYAP1R1

117
PAC1|PAC1R|PACAPR|PACAPRI
ADCYAP receptor type I
protein-coding
7p14.3
Ensembl:ENSG00000078549 MIM:102981 Vega:OTTHUMG00000023884 UniprotKB:P41586
NG_029869.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.369e-1 (AD)  6.612e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12668955chr7:31076553 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A40.891
SALL20.89
CPE0.884
ZHX30.87
DDAH10.866
NTRK20.865
DAG10.861
LRRC8A0.859
PSD20.859
WWC10.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.62
OR4F29-0.573
FCER2-0.354
GADL1-0.345
CLEC6A-0.342
OR6C74-0.332
GSDMA-0.312
CETP-0.311
WDR72-0.309
KRTAP1-1-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ADCYAP1R1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCYAP1R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCYAP1R1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCYAP1R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCYAP1R1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ADCYAP1R1 mRNA17254854
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ADCYAP1R1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of ADCYAP1R1 mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ADCYAP1R1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ADCYAP1R1 gene25435355
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADCYAP1R1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADCYAP1R1 mRNA22228805
D004958EstradiolEstradiol affects the expression of ADCYAP1R1 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of ADCYAP1R1 mRNA25181051
D002245Carbon Dioxide[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1R1 protein28506824
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCYAP1R1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ADCYAP1R1 mRNA26272509
D003520CyclophosphamideCyclophosphamide affects the expression of ADCYAP1R1 mRNA18563302
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADCYAP1R1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of ADCYAP1R1 mRNA22715380
C118739entinostatentinostat results in increased expression of ADCYAP1R1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
D000431EthanolEthanol results in decreased expression of ADCYAP1R1 mRNA20655511
C056516exemestaneexemestane results in increased expression of ADCYAP1R1 mRNA17254854
D005419FlavonoidsFlavonoids results in decreased expression of ADCYAP1R1 mRNA18035473
C039281furanfuran results in decreased expression of ADCYAP1R1 mRNA25539665
C004312glycidolglycidol results in decreased expression of ADCYAP1R1 mRNA24915197
D006220HaloperidolHaloperidol affects the expression of ADCYAP1R1 mRNA27900577
D017313FenretinideFenretinide results in decreased expression of ADCYAP1R1 mRNA28973697
D006834HydrazinesHydrazines binds to and results in decreased activity of ADCYAP1R1 protein25069645
D007854LeadLead affects the splicing of ADCYAP1R1 mRNA28903495
C042720mercuric bromidemercuric bromide results in decreased expression of ADCYAP1R1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCYAP1R1 mRNA"27188386
D008713MethimazoleMethimazole results in decreased expression of ADCYAP1R1 mRNA17403546
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADCYAP1R1 mRNA28001369
D009538NicotineNicotine results in decreased expression of ADCYAP1R1 protein28506824
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADCYAP1R1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADCYAP1R1 mRNA27935865
C076029olanzapineolanzapine affects the expression of ADCYAP1R1 mRNA27900577
D010100Oxygen[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1R1 protein28506824
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ADCYAP1R1 mRNA26272509
C494474perchlorateperchlorate results in decreased expression of ADCYAP1R1 mRNA17403546
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADCYAP1R1 mRNA27935865
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ADCYAP1R1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of ADCYAP1R1 mRNA17950772
C006253pirinixic acidpirinixic acid results in decreased expression of ADCYAP1R1 mRNA19162173
D011374ProgesteroneADCYAP1R1 protein promotes the reaction [LHB protein results in increased abundance of Progesterone]19926922
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADCYAP1R1 mRNA17403546
C017947sodium arsenitesodium arsenite affects the methylation of ADCYAP1R1 gene28589171
D013619TacrineTacrine results in increased expression of ADCYAP1R1 mRNA12832660
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADCYAP1R1 mRNA21215274
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of ADCYAP1R1 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADCYAP1R1 mRNA20133372
C012589trichostatin Atrichostatin A results in increased expression of ADCYAP1R1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased methylation of ADCYAP1R1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ADCYAP1R1 mRNA23179753|2493525
D014665Vasodilator AgentsVasodilator Agents binds to and results in increased activity of ADCYAP1R1 protein21059121
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADCYAP1R1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1R1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ADCYAP1R1 mRNA26272509
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADCYAP1R1 mRNA27935865
D015034Zinc OxideZinc Oxide analog results in decreased expression of ADCYAP1R1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004999vasoactive intestinal polypeptide receptor activity-IEA-  
GO:0005515protein binding-IPI17470806  
GO:0008179adenylate cyclase binding-IEA-  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0017046peptide hormone binding-IBA21873635  
GO:0030306ADP-ribosylation factor binding-IEA-  
GO:0038023signaling receptor activity-TAS7902709  
GO:0042923neuropeptide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007202activation of phospholipase C activity-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0010524positive regulation of calcium ion transport into cytosol-IEA-  
GO:0019933cAMP-mediated signaling-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0033555multicellular organismal response to stress-IEA-  
GO:0043950positive regulation of cAMP-mediated signaling-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0046545development of primary female sexual characteristics-IEA-  
GO:0051057positive regulation of small GTPase mediated signal transduction-IEA-  
GO:0060548negative regulation of cell death-IEA-  
GO:0060732positive regulation of inositol phosphate biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IEA-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7902709  
GO:0005901caveola-IEA-  
GO:0005923bicellular tight junction-IEA-  
GO:0009986cell surface-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-187015Activation of TRKA receptorsIEA
R-HSA-187024NGF-independant TRKA activationIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27957625A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants. (2016 Dec)Bacchelli EJ Headache Pain