Gene: ZNF488

118738
-
zinc finger protein 488
protein-coding
10q11.22
Ensembl:ENSG00000265763 Vega:OTTHUMG00000188322 UniprotKB:Q96MN9
NC_000010.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.045e-1 (AD)  4.103e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7090464chr10:47385686 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGPAT40.864
NACAD0.838
AATK0.828
TMEFF20.825
SEC14L50.819
SRCIN10.818
MAP6D10.804
NFASC0.804
MPP20.804
IFT800.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIX1-0.502
GJB2-0.473
EVC2-0.446
FOXL1-0.428
RNF135-0.425
EBF1-0.424
MTRNR2L6-0.421
AJUBA-0.419
ZIC5-0.416
PDZK1IP1-0.416

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of ZNF488 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZNF488 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZNF488 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ZNF488 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZNF488 mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of ZNF488 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of ZNF488 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of ZNF488 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of ZNF488 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of ZNF488 mRNA25181051
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ZNF488 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ZNF488 mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of ZNF488 mRNA16002434
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ZNF488 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ZNF488 mRNA27392435
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of ZNF488 mRNA19095052
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZNF488 mRNA"27188386
D010936Plant ExtractsPlant Extracts results in decreased expression of ZNF488 mRNA23557933
C107773pterostilbenepterostilbene results in decreased expression of ZNF488 mRNA22450950
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZNF488 mRNA25895662
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ZNF488 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ZNF488 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of ZNF488 mRNA23527032

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI16713569  25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0014003oligodendrocyte development-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal