Gene: PDZD8

118987
PDZK8
PDZ domain containing 8
protein-coding
10q25.3-q26.11
Ensembl:ENSG00000165650 MIM:614235 Vega:OTTHUMG00000019122 UniprotKB:Q8NEN9
NC_000010.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.821e-1 (AD)  8.015e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2532812chr10:117292277 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs363294chr10:117284043 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MON1B0.855
AGPAT50.84
PHF30.833
SAMD80.831
EXOC50.829
SMAD20.828
CANX0.825
SEC630.82
EIF3A0.819
SYNCRIP0.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.63
OR4F5-0.61
AZU1-0.21
RSPO1-0.185
FAM186A-0.173
C17orf112-0.171
MMP23B-0.169
FGF8-0.155
OR10A3-0.152
OR4F16-0.151

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of PDZD8 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDZD8 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PDZD8 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDZD8 mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of PDZD8 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDZD8 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PDZD8 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of PDZD8 mRNA24988533
D004390ChlorpyrifosChlorpyrifos affects the expression of PDZD8 mRNA26775027
D019327Copper SulfateCopper Sulfate results in increased expression of PDZD8 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PDZD8 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PDZD8 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PDZD8 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDZD8 mRNA28628672
D005557FormaldehydeFormaldehyde results in decreased expression of PDZD8 mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDZD8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDZD8 mRNA28628672
D007854LeadLead affects the expression of PDZD8 mRNA28903495
D008627Mercuric ChlorideMercuric Chloride results in increased expression of PDZD8 mRNA16507785
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PDZD8 mRNA25926378
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PDZD8 mRNA24810058
D010100OxygenOxygen deficiency results in increased expression of PDZD8 mRNA24205000
D010416PentachlorophenolPentachlorophenol results in increased expression of PDZD8 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PDZD8 protein26879310
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDZD8 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of PDZD8 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDZD8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDZD8 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDZD8 mRNA19465110|2135428
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PDZD8 mRNA28065790
D014520UrethaneUrethane results in increased expression of PDZD8 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PDZD8 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PDZD8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006869lipid transport-IEA-  
GO:0007010cytoskeleton organization-IMP21834987  
GO:0016032viral process-IEA-  
GO:0022604regulation of cell morphogenesis-IMP21834987  
GO:0035556intracellular signal transduction-IEA-  
GO:0051560mitochondrial calcium ion homeostasis-IDA29097544  
GO:1990456mitochondrion-endoplasmic reticulum membrane tethering-IDA29097544  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005789endoplasmic reticulum membrane-IDA29097544  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0044233ER-mitochondrion membrane contact site-IDA29097544  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal