Gene: TMEM132D

121256
MOLT|PPP1R153
transmembrane protein 132D
protein-coding
12q24.33
Ensembl:ENSG00000151952 MIM:611257 Vega:OTTHUMG00000168400 UniprotKB:Q14C87
NG_052808.1
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.487e-1 (AD)  6.751e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7979367chr12:129745862 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11060247chr12:129319609 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LNX10.975
ATP8A20.966
DLG30.965
RGS60.964
FRMPD40.961
NMNAT20.96
PCSK20.959
GLT1D10.958
FAXC0.957
LMTK20.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.627
YES1-0.619
MYL3-0.598
RNF135-0.598
REST-0.596
RAB13-0.591
COPZ2-0.582
RAI14-0.58
CHST14-0.578
WWTR1-0.57

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM132D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM132D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM132D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM132D mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of TMEM132D mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TMEM132D gene27153756
D0150571-NaphthylamineTMEM132D gene SNP affects the susceptibility to 1-Naphthylamine25622337
C006780bisphenol Abisphenol A results in decreased expression of TMEM132D mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TMEM132D gene28505145
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM132D mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of TMEM132D mRNA26272509
C014347decitabinedecitabine affects the expression of TMEM132D mRNA23300844
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TMEM132D mRNA28962523
D002945CisplatinCisplatin affects the expression of TMEM132D mRNA23300844
D004397FonofosFonofos results in increased methylation of TMEM132D promoter22847954
D019833GenisteinGenistein results in increased methylation of TMEM132D gene28505145
C042720mercuric bromidemercuric bromide results in decreased expression of TMEM132D mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM132D mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM132D mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TMEM132D mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TMEM132D mRNA"25554681
D010278ParathionParathion results in increased methylation of TMEM132D promoter22847954
D010634PhenobarbitalPhenobarbital affects the methylation of TMEM132D gene19233941
D010936Plant ExtractsPlant Extracts results in decreased expression of TMEM132D mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of TMEM132D mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of TMEM132D mRNA24780913
D053260SootSoot results in decreased expression of TMEM132D mRNA26551751
C012568terbufosterbufos results in increased methylation of TMEM132D promoter22847954
D014635Valproic AcidValproic Acid results in increased expression of TMEM132D mRNA24383497
D014635Valproic AcidValproic Acid results in increased methylation of TMEM132D gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19389623  
GO ID GO Term Qualifier Evidence PubMed
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-NAS12966072  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27318301Genome-wide significant loci for addiction and anxiety. (2016 Aug)Hodgson KEur Psychiatry