Gene: SLC24A4

123041
AI2A5|NCKX4|SHEP6|SLC24A2
solute carrier family 24 member 4
protein-coding
14q32.12
Ensembl:ENSG00000140090 MIM:609840 Vega:OTTHUMG00000167589 UniprotKB:Q8NFF2
NG_023408.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.159e-1 (AD)  8.901e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8019291chr14:92464820 (GRCh38.p7)G>C / G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01499816chr14:92807984SLC24A41.200e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAPK10.855
IGSF30.846
DLGAP20.841
NDST30.839
CSMD10.839
FAT30.838
MTUS20.837
TMEM178B0.837
CACNA1D0.836
LRRTM40.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.489
CSAG1-0.473
ROM1-0.473
PGF-0.462
RAB13-0.461
SNHG18-0.46
RAI14-0.452
MYL3-0.442
FLT3LG-0.44
GNG11-0.439

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of SLC24A4 mRNA22193206
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC24A4 mRNA21298039
D001151ArsenicArsenic affects the methylation of SLC24A4 gene25304211
C015001arsenitearsenite results in decreased methylation of SLC24A4 promoter23974009
D001280AtrazineAtrazine results in increased expression of SLC24A4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SLC24A4 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of SLC24A4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC24A4 gene28505145
C039671ciglitazoneciglitazone results in decreased expression of SLC24A4 mRNA22193206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC24A4 mRNA21139344
D003042CocaineCocaine results in increased expression of SLC24A4 mRNA17898221
D003471CuprizoneCuprizone results in decreased expression of SLC24A4 mRNA27523638
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of SLC24A4 mRNA22193206
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of SLC24A4 mRNA19118595
C069837fullerene C60fullerene C60 results in increased expression of SLC24A4 mRNA19167457
C039281furanfuran results in increased expression of SLC24A4 mRNA25539665
C004312glycidolglycidol results in decreased expression of SLC24A4 mRNA24915197
C018091maduramicinmaduramicin results in increased expression of SLC24A4 mRNA29128925
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SLC24A4 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC24A4 mRNA"25554681
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in decreased expression of SLC24A4 mRNA19176365
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in decreased expression of SLC24A4 mRNA19176365
C046012pentanalpentanal results in increased expression of SLC24A4 mRNA26079696
D010936Plant ExtractsPlant Extracts results in increased expression of SLC24A4 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of SLC24A4 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of SLC24A4 mRNA19690047
D011441PropylthiouracilPropylthiouracil affects the expression of SLC24A4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC24A4 mRNA25895662
D012834SilverSilver results in increased expression of SLC24A4 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of SLC24A4 mRNA27257137
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-IBA21873635  
GO:0008273calcium, potassium:sodium antiporter activity-IBA21873635  
GO:0008273calcium, potassium:sodium antiporter activity-TAS-  
GO:0015293symporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0006813potassium ion transport-IEA-  
GO:0006874cellular calcium ion homeostasis-IBA21873635  
GO:0007608sensory perception of smell-IBA21873635  
GO:0007608sensory perception of smell-ISS-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0050896response to stimulus-IEA-  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-IEA-  
GO:0097186amelogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016020membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425561Sodium/Calcium exchangersTAS
R-HSA-5619055Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
27459457Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep)Li WQAm J Public Health