Gene: ADH1A

124
ADH1
AD dehydrogenase 1A (class I), alpha polypeptide
protein-coding
4q23
Ensembl:ENSG00000187758 MIM:103700 Vega:OTTHUMG00000131026 UniprotKB:P07327
NC_000004.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.855e-1 (AD)  5.482e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs904092chr4:99293007 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEFB1100.496
F90.472
SLC9A40.472
HMGCS20.464
CYP2C90.461
OR2G20.46
ITIH10.442
AMBP0.442
TCN10.436
GC0.431

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DMRT3-0.241
INSM1-0.24
OPRD1-0.235
LRRN1-0.234
POU3F2-0.232
GJD2-0.224
TOX3-0.221
GJB3-0.218
KCNG1-0.21
CALB2-0.209

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB01213FomepizoleSmall Molecule7554-65-6ApprovedTarget
DB027214-IodopyrazoleSmall Molecule3469-69-0ExperimentalTarget
DB04065N-Cyclopentyl-N-CyclobutylformamideSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
ID Drug Name Action PubMed
C0475192,2'-thiodiethanol"ADH1A protein affects the metabolism of 2,2'-thiodiethanol"16417912
C0439582-butanolADH1A protein binds to and results in increased metabolism of 2-butanol1618764
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA]27055685
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A protein]27055685
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of ADH1A mRNA25716159
C106538abacavir[ADH1A protein binds to ADH1A protein] which results in increased metabolism of abacavir12399160
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADH1A mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADH1A gene27153756
C004984apocarotenalapocarotenal results in increased expression of ADH1A mRNA17034753
C006632arsenic trioxidearsenic trioxide results in increased expression of ADH1A mRNA20458559
D019207beta Carotenebeta Carotene results in increased expression of ADH1A mRNA17034753
D004958EstradiolEstradiol results in decreased expression of ADH1A mRNA20106945
C018475butyraldehydebutyraldehyde results in increased expression of ADH1A mRNA26079696
D002927CimetidineCimetidine inhibits the reaction [ADH1A protein results in increased oxidation of Ethanol]23220590
D003511CyclohexanolsADH1A protein binds to and results in increased metabolism of Cyclohexanols1618764
D016572CyclosporineCyclosporine results in decreased expression of ADH1A mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of ADH1A mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH1A mRNA28628672
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1A mRNA26159488
D004726EndosulfanEndosulfan results in decreased expression of ADH1A mRNA26159488
D000431EthanolADH1A protein results in increased oxidation of Ethanol21167143|2322059
D000431EthanolCimetidine inhibits the reaction [ADH1A protein results in increased oxidation of Ethanol]23220590
D000431EthanolEthanol results in increased expression of ADH1A mRNA23300006
D000431EthanolEthanol results in increased expression of ADH1A protein23300006
D000431Ethanolfomepizole inhibits the reaction [ADH1A protein results in increased oxidation of Ethanol]21167143
D000431EthanolADH1A protein binds to and results in increased metabolism of Ethanol1618764
D019855Ethylene GlycolADH1A protein results in increased oxidation of Ethylene Glycol21167143
C010238fomepizolefomepizole inhibits the reaction [ADH1A protein results in increased oxidation of Ethanol]21167143
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH1A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH1A mRNA28628672
D000432MethanolADH1A protein results in increased oxidation of Methanol21167143
D010634PhenobarbitalPhenobarbital results in decreased expression of ADH1A mRNA19084549
D0198402-PropanolADH1A protein results in increased oxidation of 2-Propanol21167143
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of ADH1A mRNA26100227
C009237senecioninesenecionine results in decreased expression of ADH1A mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of ADH1A mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADH1A mRNA25895662
C080703SK&F 83959SK&F 83959 affects the expression of ADH1A protein25852303
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA]27055685
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A protein]27055685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA]27055685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A protein]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA]27055685
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1A mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH1A mRNA11489354|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH1A protein27055685
D014212TretinoinTretinoin results in increased expression of ADH1A mRNA23830798
D014635Valproic AcidValproic Acid results in decreased expression of ADH1A mRNA29154799
C574123walrycin Awalrycin A results in increased expression of ADH1A mRNA22314385
C088658zoledronic acidzoledronic acid results in decreased expression of ADH1A mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004022alcohol dehydrogenase (NAD) activity-TAS-  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-EXP9982  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-IDA9982  
GO:0004745retinol dehydrogenase activity-TAS-  
GO:0005515protein binding-IPI16153155  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006066alcohol metabolic process-NAS2347582  
GO:0006069ethanol oxidation-TAS-  
GO:0017144drug metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-2161522Abacavir transport and metabolismTAS
R-HSA-2161541Abacavir metabolismTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-5365859RA biosynthesis pathwayTAS
R-HSA-71384Ethanol oxidationTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
23468174Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)Zuo LHum Genet
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
23387924Genome-wide DNA methylation analysis in alcohol dependence. (2013 Mar)Zhang RAddict Biol
17185388Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (2007 Feb 15)Luo XHum Mol Genet
23456092Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)Park BLHum Genet
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
19193628ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (2009 Apr 15)Birley AJHum Mol Genet
16571603Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. (2006 May 1)Edenberg HJHum Mol Genet
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res
29166882Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India. (2017 Nov 22)Ghosh SBMC Cancer