Gene: CDYL2

124359
PCCP1
chromodomain Y like 2
protein-coding
16q23.2
Ensembl:ENSG00000166446 Vega:OTTHUMG00000177004 UniprotKB:Q8N8U2
NC_000016.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.575e-2 (AD)  7.009e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9927571chr16:80623069 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12448290chr16:80621986 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGAP260.914
RAPGEF20.9
KLHL180.899
FBXO340.896
RBBP50.895
KCND30.895
CCDC60.894
MAPK140.893
TIAM20.89
PHLPP20.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.415
HEY2-0.409
RARRES2-0.405
MBNL3-0.405
COPZ2-0.405
S100A1-0.405
OR4F5-0.401
AQP5-0.394
RBP1-0.394
HMX1-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CDYL2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CDYL2 mRNA"21346803
C0541213-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanoneCDYL2 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone25622337
D020106AcrylamideAcrylamide results in decreased expression of CDYL2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDYL2 mRNA19770486
D000447AldehydesAldehydes results in increased expression of CDYL2 mRNA25014914
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDYL2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDYL2 mRNA19770486
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of CDYL2 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of CDYL2 mRNA24758408
C006780bisphenol Abisphenol A results in decreased methylation of CDYL2 promoter27312807
C006780bisphenol Abisphenol A affects the methylation of CDYL2 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of CDYL2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CDYL2 mRNA26079696
D002945CisplatinCisplatin results in decreased expression of CDYL2 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDYL2 mRNA29097150
D017313FenretinideFenretinide results in decreased expression of CDYL2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDYL2 mRNA25613284
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of CDYL2 mRNA29162477
C047806monomethylpropionmonomethylpropion results in increased expression of CDYL2 mRNA22303338
C028007nickel monoxidenickel monoxide results in increased expression of CDYL2 mRNA19167457
C046012pentanalpentanal results in increased expression of CDYL2 mRNA26079696
D010938Plant OilsPlant Oils results in increased expression of CDYL2 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDYL2 mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of CDYL2 mRNA26079696
D012834SilverSilver affects the expression of CDYL2 mRNA27131904
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDYL2 mRNA25613284
D014520UrethaneUrethane results in increased expression of CDYL2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003824catalytic activity-IEA-  
GO:0005515protein binding-IPI17577209  23455924  
GO:0035064methylated histone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008152metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal