Gene: MSI2

124540
MSI2H
musashi RNA binding protein 2
protein-coding
17q22
Ensembl:ENSG00000153944 MIM:607897 Vega:OTTHUMG00000178398 UniprotKB:Q96DH6
NC_000017.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.407e-1 (AD)  1.507e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9890811chr17:57335100 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20433952chr17:55607898MSI27.800e-8Smoking27651444
cg08677210chr17:55550613MSI23.320e-12Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH9A10.912
ALDH6A10.911
AMOT0.905
APPL20.905
ARHGEF260.904
MAOA0.904
NTRK20.901
DHTKD10.898
SLC1A30.897
TP53BP20.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.52
OR4F29-0.494
QRFPR-0.389
DUSP27-0.377
CACNA1F-0.371
ADTRP-0.364
AGMAT-0.364
GALNT14-0.36
TRABD2A-0.351
RTP1-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of MSI2 mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSI2 mRNA"27188386
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of MSI2 mRNA26975756
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSI2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MSI2 mRNA21420995|2223033
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MSI2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MSI2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of MSI2 mRNA21757418
D001151ArsenicArsenic affects the methylation of MSI2 gene25304211
D001151ArsenicArsenic results in decreased expression of MSI2 mRNA19654921
C015001arsenitearsenite results in increased methylation of MSI2 promoter23974009
D001280AtrazineAtrazine results in increased expression of MSI2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MSI2 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSI2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSI2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSI2 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MSI2 mRNA"26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MSI2 mRNA"20018196
C044887beta-methylcholinebeta-methylcholine affects the expression of MSI2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MSI2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MSI2 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of MSI2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of MSI2 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MSI2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of MSI2 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of MSI2 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of MSI2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of MSI2 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in increased expression of MSI2 mRNA24921660
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MSI2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MSI2 mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of MSI2 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of MSI2 mRNA]21852083
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MSI2 mRNA"22485181
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of MSI2 mRNA"27840820
D004147DioxinsDioxins affects the expression of MSI2 mRNA20463971
D004237DiuronDiuron results in decreased expression of MSI2 mRNA25152437
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MSI2 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of MSI2 mRNA23649840
D019833GenisteinGenistein results in decreased expression of MSI2 mRNA18847459
D017313FenretinideFenretinide results in increased expression of MSI2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MSI2 mRNA20044591
C045463leflunomideleflunomide results in increased expression of MSI2 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MSI2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MSI2 mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MSI2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MSI2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MSI2 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MSI2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MSI2 mRNA25729387
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MSI2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of MSI2 mRNA20813756
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of MSI2 mRNA]21852083
D012402RotenoneRotenone results in decreased expression of MSI2 mRNA19013527
C009277sodium arsenatesodium arsenate results in decreased expression of MSI2 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of MSI2 mRNA21795629
C016104sodium bichromatesodium bichromate affects the expression of MSI2 mRNA22110744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MSI2 mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of MSI2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MSI2 mRNA19969065
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MSI2 mRNA18087596
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MSI2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of MSI2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of MSI2 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of MSI2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of MSI2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSI2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MSI2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MSI2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of MSI2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MSI2 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of MSI2 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of MSI2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0008266poly(U) RNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0048864stem cell development-IEA-  
GO:0051252regulation of RNA metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005844polysome-IBA21873635  
GO:0005844polysome-IEA-  
KEGG ID KEGG Term
hsa03015mRNA surveillance pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol