Gene: ADH1C

126
ADH3
AD dehydrogenase 1C (class I), gamma polypeptide
protein-coding
4q23
Ensembl:ENSG00000248144 MIM:103730 Vega:OTTHUMG00000161422 UniprotKB:P00326
NG_011718.1
PubMed|SNP Mapped
ND|AD
79   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.291e-1 (AD)  7.418e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1789924chr4:99353129 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs34761493chr4:99352013 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12639833chr4:99346215 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1662051chr4:99346082 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6532815chr4:99345999 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2241894chr4:99344976 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1789911chr4:99342621 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs904095chr4:99342226 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1614972chr4:99336998 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2298753chr4:99336750 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00689360chr4:100273995ADH1C1.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAL0.484
ADH1B0.477
TMEM710.457
CLEC2D0.44
ALX10.418
P2RX10.409
MAGEB40.408
PROS10.406
RPGRIP10.404
FMO30.401

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDT1-0.301
CHAC1-0.301
NPSR1-0.275
CHRNA4-0.269
BCL11A-0.263
ADRA2A-0.262
FAM163B-0.261
DRD5-0.26
CYP26A1-0.255
CRYGD-0.255

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB01213FomepizoleSmall Molecule7554-65-6ApprovedTarget
DB017112,3,4,5,6-Pentafluorobenzyl AlcoholSmall Molecule440-60-8ExperimentalTarget
DB02131N-1-MethylheptylformamideSmall MoleculeExperimentalTarget
DB022492-EthoxyethanolSmall Molecule110-80-5ExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB027214-IodopyrazoleSmall Molecule3469-69-0ExperimentalTarget
DB02757PyrazoleSmall Molecule288-13-1ExperimentalTarget
DB02822Para-Bromobenzyl AlcoholSmall Molecule873-75-6ExperimentalTarget
DB028713-Butylthiolane 1-OxideSmall MoleculeExperimentalTarget
DB030205-Beta-D-Ribofuranosylnicotinamide Adenine DinucleotideSmall MoleculeExperimentalTarget
DB03061(R)-N-(1-Methyl-Hexyl)-FormamideSmall MoleculeExperimentalTarget
DB03226TrifluoroethanolSmall MoleculeExperimentalTarget
DB03559CyclohexylformamideSmall MoleculeExperimentalTarget
DB04071CpadSmall MoleculeExperimentalTarget
DB04113N-FormylpiperidineSmall MoleculeExperimentalTarget
DB043122,3-Difluorobenzyl AlcoholSmall MoleculeExperimentalTarget
DB044482,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)BenzeneSmall MoleculeExperimentalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
ID Drug Name Action PubMed
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of ADH1C mRNA25716159
C0293704-toluidine4-toluidine results in increased expression of ADH1C mRNA27638505
D000079Acetaldehyde[ADH1C protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde15138216
D000082AcetaminophenAcetaminophen results in decreased expression of ADH1C mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ADH1C protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADH1C mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ADH1C mRNA21757418
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ADH1C gene25435355
D004958EstradiolEstradiol results in decreased expression of ADH1C mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of ADH1C mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of ADH1C mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of ADH1C mRNA22842222|2518105
D002927CimetidineCimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]23220590
D003300CopperCopper results in increased expression of ADH1C mRNA24403277
D016572CyclosporineCyclosporine results in decreased expression of ADH1C mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of ADH1C mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH1C mRNA28628672
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ADH1C mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of ADH1C mRNA26924002
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1C mRNA26159488
D000431EthanolADH1C gene polymorphism affects the susceptibility to Ethanol20171022
D000431EthanolADH1C protein results in increased metabolism of Ethanol15138216|1982219
D000431Ethanol[ADH1C protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde15138216
D000431EthanolADH1C protein results in increased oxidation of Ethanol21167143|2322059
D000431EthanolCimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]23220590
D000431EthanolEthanol results in increased expression of ADH1C mRNA23300006
D000431Ethanolfomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]21167143
D000431EthanolPentachlorophenol inhibits the reaction [ADH1C protein results in increased metabolism of Ethanol]19822198
D000431EthanolEthanol results in decreased expression of ADH1C protein23200777
D019855Ethylene GlycolADH1C protein results in increased oxidation of Ethylene Glycol21167143
D011345FenofibrateFenofibrate results in decreased expression of ADH1C mRNA25572481
C010238fomepizolefomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]21167143
D017313FenretinideFenretinide results in increased expression of ADH1C mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH1C mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ADH1C mRNA28628672
C052901lemongrass oillemongrass oil affects the expression of ADH1C mRNA25976427
C052901lemongrass oillemongrass oil results in decreased expression of ADH1C mRNA25660481
D000432MethanolADH1C protein results in increased oxidation of Methanol21167143
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ADH1C mRNA26924002
C464660obeticholic acidobeticholic acid results in decreased expression of ADH1C mRNA27939613
D009853OmeprazoleOmeprazole results in decreased expression of ADH1C mRNA12040753
D010100OxygenOxygen deficiency results in decreased expression of ADH1C mRNA19695866
D010416PentachlorophenolPentachlorophenol inhibits the reaction [ADH1C protein results in increased metabolism of Ethanol]19822198
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of ADH1C mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ADH1C mRNA27153767
D011374ProgesteroneProgesterone results in increased expression of ADH1C mRNA20864642
D0198402-PropanolADH1C protein results in increased oxidation of 2-Propanol21167143
C005556propionaldehydepropionaldehyde results in decreased expression of ADH1C mRNA26079696
D012293RifampinRifampin results in increased expression of ADH1C mRNA12040753
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADH1C mRNA25895662
D010042OuabainOuabain affects the expression of ADH1C protein17268060
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1C mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADH1C mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH1C mRNA20106945|2615948
D014212TretinoinTretinoin results in increased expression of ADH1C mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADH1C mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ADH1C mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of ADH1C mRNA29154799
C574123walrycin Awalrycin A results in increased expression of ADH1C mRNA22314385
D015032ZincZinc deficiency results in decreased expression of ADH1C mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004022alcohol dehydrogenase (NAD) activity-IDA6391957  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-EXP9982  
GO:0004745retinol dehydrogenase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006069ethanol oxidation-IDA6391957  
GO:0006069ethanol oxidation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-5365859RA biosynthesis pathwayTAS
R-HSA-71384Ethanol oxidationTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
28937693Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)Clarke TKMol Psychiatry
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
19193628ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (2009 Apr 15)Birley AJHum Mol Genet
21351086Shortened telomeres in individuals with abuse in alcohol consumption. (2011 Aug 15)Pavanello SInt J Cancer
23516558Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. (2013)Biernacka JMPLoS One
25208201Subjective response to alcohol and ADH polymorphisms in a select sample of young adult male East Indians and Africans in Trinidad and Tobago. (2014 Sep)Montane Jaime LKJ Stud Alcohol Drugs
27172571Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. (2016 May)Chartier KGJ Stud Alcohol Drugs
16930209Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians. (2006 Sep)Duranceaux NCAlcohol Clin Exp Res
15897724Mean corpuscular volume and ADH1C genotype in white patients with alcohol-associated diseases. (2005 May)Sun LAlcohol Clin Exp Res
19189524[Distribution of alcohol dehydrogenase (ADH1C) genotypes in subjects with tobacco smoke-associated laryngeal cancer]. (2008)Arndt MPrzegl Lek
26042511Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis. (2015 May 17)Vatansever SBosn J Basic Med Sci
22004471Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. (2012 Jan)Frank JAddict Biol
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res
28610454Genetic polymorphisms of alcohol-metabolizing enzymes and their association with alcoholism risk, personality and anthropometric traits among Malaysian university students. (2018 Feb)Ong HHPsychol Health Med
18242813Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. (2008 Mar 12)Kollock RToxicology
29058377Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. (2017 Oct 23)Sanchez-Roige SAddict Biol
22325912Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey. (2012 Mar)Aktas EOSci Justice
12050823A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. (2002 Jul)Osier MVAm J Hum Genet
14726542Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke. (2004 Feb)Zee RYStroke
25660313Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)Forero DADrug Alcohol Depend
16600530Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. (2006 Sep 15)Lorenzo ADrug Alcohol Depend
28714907Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. (2017 Jul 17)Treutlein JGenes (Basel)
24735490Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. (2015 May)Way MAddict Biol
15564879Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. (2004 Nov)Lee SLPharmacogenetics
15654505Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)Liu YJ Hum Genet
17285601Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (2007 May)Matsuo KHum Mutat
26842247Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. (2016 Feb)Wu LSAlcohol Clin Exp Res
17923853Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. (2008 Jun)Tolstrup JSPharmacogenomics J
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res
22978509Convergence of genome-wide association and candidate gene studies for alcoholism. (2012 Dec)Olfson EAlcohol Clin Exp Res
23134050Genes encoding enzymes involved in ethanol metabolism. (2012)Hurley TDAlcohol Res
17718394The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (2007)Edenberg HJAlcohol Res Health
17718397ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. (2007)Eng MYAlcohol Res Health
17718398Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007)Moore SAlcohol Res Health
21917409Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers. (2012 Feb)Pavanello SAlcohol
23404349Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms. (2013 Apr)Bonaventure ACancer Causes Control
16086315Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism. (2005 Sep)Choi IGHum Mutat
29084628First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil. (2017 Dec)Teixeira TMAlcohol
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
20714161Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. (2010)Mustavich LFHum Hered
12500098A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans. (2002 Dec)Osier MVAlcohol Clin Exp Res
20477767Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. (2010 Jul)Yokoyama AAlcohol Clin Exp Res
17250612Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad. (2007 Feb)Ehlers CLAlcohol Clin Exp Res
16766085GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype. (2006 Nov)Buckley STNeurochem Int
25372623Association between ADH1C and ALDH2 polymorphisms and alcoholism in a Turkish sample. (2015 Apr)Ayhan YNord J Psychiatry
25271825Asian flushing: genetic and sociocultural factors of alcoholism among East asians. (2014 Sep-Oct)Lee HGastroenterol Nurs
15643610Natural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C (ADH1C) gene expression. (2005 Feb)Chen HJHum Mutat
29166882Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India. (2017 Nov 22)Ghosh SBMC Cancer
25874489Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma. (2015 Jun)Ji YBTumour Biol
17185388Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (2007 Feb 15)Luo XHum Mol Genet
28815635Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. (2017 Oct)Peng QAlcohol Clin Exp Res
22414625Association of a genetic polymorphism of the alcohol-metabolizing enzyme ADH1C with alcohol dependence: results of a case-control study. (2012)Kortunay SEur Addict Res
21303386Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador. (2011 May)Celorrio DAlcohol Clin Exp Res
22320931Interactions of alcohol and tobacco in gastrointestinal cancer. (2012 Mar)Salaspuro MJ Gastroenterol Hepatol
22931071ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. (2012 Sep)Ehlers CLAm J Drug Alcohol Abuse
22048268Combined effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 alleles on alcoholism and chronic liver diseases. (2011)Toth RDis Markers
20953317Co-morbidity of alcohol dependence and select affective and anxiety disorders among individuals of East Indian and African ancestry in Trinidad and Tobago. (2009 Mar)Shafe SWest Indian Med J
19861527Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (2009 Nov)Oze ICancer Epidemiol Biomarkers Prev
18761854[Genetic variations in alcohol dehydrogenase, drinking habits and alcoholism]. (2008 Aug 25)Tolstrup JSUgeskr Laeger
18996923Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. (2009 Feb 1)Macgregor SHum Mol Genet
12884000Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. (2003 Sep)Mulligan CJHum Genet
20401433Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. (2010 Mar)Cichoz-Lach HBraz J Med Biol Res
17134660ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago. (2006 Jun)Montane-Jaime KAlcohol
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. (2014 Jan)Gelernter JMol Psychiatry
27163368Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. (2016)Wall TLAlcohol Res
16404797Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. (2005 Dec)Wall TLTher Drug Monit
15318112ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. (2004 Aug)Konishi TAlcohol Clin Exp Res
16184481Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. (2005 Sep)Birley AJBehav Genet
19581569Genome-wide association study of alcohol dependence. (2009 Jul)Treutlein JArch Gen Psychiatry
15542698Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. (2004 Oct)Foley PFAnn N Y Acad Sci
17885622Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. (2007 Oct)Peng GSPharmacogenet Genomics
22476623Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. (2012 Aug)Li DHum Genet
17105908Genes and gene expression in the brains of human alcoholics. (2006 Aug)Dodd PRAnn N Y Acad Sci
23468174Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)Zuo LHum Genet
28805974Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. (2017 Aug)Katsarou MSPharmacol Res Perspect
15734975The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. (2005 Feb)Peters ESCancer Epidemiol Biomarkers Prev
17071628Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. (2007 Apr)Asakage TCarcinogenesis
24680035Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. (2014 Jun)Ahrens WOral Oncol