Gene: ARL8A

127829
ARL10B|GIE2
ADP ribosylation factor like GTPase 8A
protein-coding
1q32.1
Ensembl:ENSG00000143862 MIM:616597 Vega:OTTHUMG00000035923 UniprotKB:Q96BM9
NC_000001.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.498e-1 (AD)  7.107e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17435204chr1:202137868 (GRCh38.p7)T>A / T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF1670.954
DHPS0.952
MAP7D10.951
GDI10.949
WIPI20.948
ACTR1A0.946
PRCC0.946
MTCH10.946
TBC1D10B0.944
CLTA0.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.769
OR4F29-0.736
MTRNR2L6-0.375
MTRNR2L9-0.373
MTRNR2L10-0.365
KCNJ15-0.345
IL18RAP-0.34
TFPI2-0.338
EBF1-0.335
CXCR2-0.325

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ARL8A protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ARL8A mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of ARL8A mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ARL8A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARL8A mRNA21632981|2164198
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARL8A mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARL8A mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ARL8A mRNA"26238291
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of ARL8A mRNA"20162321
C006780bisphenol Abisphenol A results in decreased expression of ARL8A mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARL8A mRNA28628672
D000069286BortezomibBortezomib results in increased expression of ARL8A mRNA20977926
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARL8A gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of ARL8A mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of ARL8A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ARL8A mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARL8A mRNA28628672
D002945CisplatinCisplatin results in increased expression of ARL8A mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ARL8A mRNA23649840
D005485FlutamideFlutamide results in increased expression of ARL8A mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARL8A gene20938992
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARL8A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARL8A mRNA28628672
D007854LeadLead affects the expression of ARL8A mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARL8A gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ARL8A mRNA23649840
C031721naphthalenenaphthalene results in increased expression of ARL8A mRNA18978301
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ARL8A mRNA25380136
D010416PentachlorophenolPentachlorophenol results in increased expression of ARL8A mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of ARL8A mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARL8A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ARL8A mRNA19482888
C017947sodium arsenitesodium arsenite affects the expression of ARL8A mRNA20816728
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARL8A mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARL8A mRNA21570461|2468072
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ARL8A mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-NAS15331635  
GO:0005515protein binding-IPI24955142  25416956  25898167  
GO:0005525GTP binding-IDA15331635  
GO:0043014alpha-tubulin binding-ISS15331635  
GO:0048487beta-tubulin binding-ISS15331635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0007059chromosome segregation-ISS14871887  
GO:0043312neutrophil degranulation-TAS-  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15331635  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005765lysosomal membrane-IBA21873635  
GO:0005774vacuolar membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030496midbody-IDA15331635  
GO:0031902late endosome membrane-IEA-  
GO:0035577azurophil granule membrane-TAS-  
GO:0051233spindle midzone-IDA15331635  
GO:0070062extracellular exosome-HDA19056867  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal