Gene: WDR64

128025
-
WD repeat domain 64
protein-coding
1q43
Ensembl:ENSG00000162843 UniprotKB:B1ANS9
NC_000001.11
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
8.483e-1 (AD)  8.230e-1 (ND)   (Frontal_Cortex)
3.710e-1 (AD)  5.060e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10926554chr1:241730784 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs9782914chr1:241728933 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9428890chr1:241705047 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL5A20.511
FREM10.496
LAMB10.491
LRRK10.481
USP430.481
KCNH40.478
SLC29A10.476
DEPDC50.475
ABHD12B0.473
CDKL10.47

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HBA2-0.306
ZHX2-0.298
CBFB-0.297
TGFB3-0.296
CHST3-0.294
HEY2-0.29
FOXO1-0.287
MORC4-0.285
ACTL6A-0.285
MAGT1-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of WDR64 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of WDR64 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of WDR64 mRNA25181051
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of WDR64 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in increased expression of WDR64 mRNA20105288
D008727MethotrexateMethotrexate results in increased expression of WDR64 mRNA24449571
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WDR64 mRNA19710929
D012969Sodium FluorideSodium Fluoride results in decreased expression of WDR64 mRNA27862939
D012969Sodium FluorideSodium Fluoride results in increased expression of WDR64 protein28918527
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of WDR64 mRNA20105288

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal