Gene: SGSM1

129049
RUTBC2
small G protein signaling modulator 1
protein-coding
22q11.23
Ensembl:ENSG00000167037 MIM:611417 Vega:OTTHUMG00000150837 UniprotKB:Q2NKQ1
NC_000022.11
SNP Mapped
3   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.780e-1 (AD)  4.382e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5760740chr22:24926206 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs139724chr22:24888862 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs5996775chr22:24842325 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRRG30.941
UBE2O0.94
LONRF20.937
L1CAM0.936
CLSTN30.936
ADD20.934
GLS20.933
SYN20.933
AP3B20.933
NSF0.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.526
ASB4-0.524
YES1-0.511
RAI14-0.496
HEY2-0.495
MYL3-0.491
MBNL3-0.491
REST-0.484
FZD10-0.482
MYOM1-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of SGSM1 mRNA28959563
D001280AtrazineAtrazine results in decreased expression of SGSM1 mRNA26331294
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SGSM1 mRNA26001963
C006780bisphenol Abisphenol A results in increased expression of SGSM1 mRNA28196854
C006780bisphenol Abisphenol A affects the expression of SGSM1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SGSM1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of SGSM1 protein28903499
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SGSM1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SGSM1 mRNA18353800
C014347decitabinedecitabine affects the expression of SGSM1 mRNA23300844
D002945CisplatinCisplatin affects the expression of SGSM1 mRNA23300844
D004041Dietary FatsDietary Fats results in decreased expression of SGSM1 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SGSM1 mRNA24535843
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SGSM1 gene20938992
C039281furanfuran results in increased expression of SGSM1 mRNA27387713
D017313FenretinideFenretinide results in increased expression of SGSM1 mRNA28973697
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SGSM1 gene20938992
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SGSM1 mRNA"29244179
D009532NickelNickel results in decreased expression of SGSM1 mRNA24768652|2558310
C006253pirinixic acidpirinixic acid results in decreased expression of SGSM1 mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in increased expression of SGSM1 protein23718831
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SGSM1 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SGSM1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SGSM1 mRNA28922406
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SGSM1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SGSM1 mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of SGSM1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SGSM1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SGSM1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IDA22637480  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0017137Rab GTPase binding-IPI22637480  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0090630activation of GTPase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-IDA22637480  
GO:0030659cytoplasmic vesicle membrane-IDA22637480  
GO:0030659cytoplasmic vesicle membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal