Gene: CPNE4

131034
COPN4|CPN4
copine 4
protein-coding
3q22.1
Ensembl:ENSG00000196353 MIM:604208 Vega:OTTHUMG00000159631 UniprotKB:Q96A23
NC_000003.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.757e-1 (AD)  7.881e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs924949chr3:132265544 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12634678chr3:132056472 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF385B0.958
IPCEF10.957
SV2B0.947
DIRAS20.944
PTPRT0.941
NELL20.94
PRKCE0.939
SLITRK10.938
CDK140.936
SYT10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.597
YES1-0.59
WWTR1-0.585
RNF135-0.578
HEY2-0.578
CMTM3-0.566
REST-0.565
ASB4-0.563
EMP3-0.556
CHST14-0.55

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CPNE4 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CPNE4 mRNA"21394737
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CPNE4 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CPNE4 gene27153756
D000639AmitriptylineAmitriptyline results in decreased expression of CPNE4 mRNA22341215
D001151ArsenicArsenic affects the methylation of CPNE4 gene25304211
C487081belinostatbelinostat results in increased expression of CPNE4 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPNE4 mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of CPNE4 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of CPNE4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of CPNE4 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CPNE4 mRNA27858113
D003471CuprizoneCuprizone results in decreased expression of CPNE4 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of CPNE4 mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CPNE4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CPNE4 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CPNE4 mRNA25016146
C118739entinostatentinostat results in increased expression of CPNE4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C082360fipronilfipronil results in increased expression of CPNE4 mRNA23962444
D005557FormaldehydeFormaldehyde results in decreased expression of CPNE4 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CPNE4 mRNA27392435
D008701MethapyrileneMethapyrilene results in increased methylation of CPNE4 gene26431795
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of CPNE4 mRNA21628967
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CPNE4 mRNA23649840
D009532NickelNickel results in decreased expression of CPNE4 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of CPNE4 mRNA19167457
C025589ochratoxin Aochratoxin A results in decreased methylation of CPNE4 gene26431795
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CPNE4 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of CPNE4 mRNA22178795
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CPNE4 mRNA19710929
D011441PropylthiouracilPropylthiouracil affects the expression of CPNE4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CPNE4 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of CPNE4 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CPNE4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased methylation of CPNE4 gene26431795
D014212TretinoinTretinoin results in decreased expression of CPNE4 mRNA21934132|2372400
C012589trichostatin Atrichostatin A results in increased expression of CPNE4 mRNA24935251
D017974Uranium CompoundsUranium Compounds results in decreased expression of CPNE4 mRNA19654044
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPNE4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CPNE4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CPNE4 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CPNE4 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of CPNE4 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12522145  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0071277cellular response to calcium ion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal