Gene info: ID 131544

Gene: CRYBG3

GENE ID: 131544

Synonyms: DKFZp667G2110|vlAKAP

Description: crystallin beta-gamma domain containing 3

Gene type: protein-coding

Location: 3q11.2

dbXrefs: Ensembl:ENSG00000080200 Vega:OTTHUMG00000159187 UniprotKB:Q68DQ2

RefSeq: NC_000003.12

Retrived from: SNP Mapped

SNPs: 7 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.375e-1 (AD) 1.178e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1391665	chr3:97914893 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4857068	chr3:97903853 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1498652	chr3:97901684 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs6786354	chr3:97876535 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs3856567	chr3:97864832 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs699300	chr3:97847729 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1848035	chr3:97823011 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZBED6	0.833
CYP7B1	0.638
MKLN1	0.634
KIAA0754	0.627
NBEAL1	0.622
ZNF354C	0.614
BBX	0.607
HEATR5A	0.598
USP37	0.596
ALMS1	0.596

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TRIM54	-0.438
AZU1	-0.414
SPEF1	-0.376
CYP4A11	-0.373
TMEM191C	-0.371
BEST4	-0.369
PIP5KL1	-0.366
PRTN3	-0.362
CKMT1B	-0.359
ADCK5	-0.352

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CRYBG3 mRNA"	22698814
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"	25510870
D000082	Acetaminophen	Acetaminophen results in increased expression of CRYBG3 mRNA	26690555
D020106	Acrylamide	Acrylamide results in increased expression of CRYBG3 mRNA	28959563
C547126	AZM551248	AZM551248 results in decreased expression of CRYBG3 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CRYBG3 mRNA	22228805
C006780	bisphenol A	bisphenol A results in decreased expression of CRYBG3 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of CRYBG3 mRNA	26079696
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CRYBG3 mRNA	19549813
D002117	Calcitriol	Calcitriol results in increased expression of CRYBG3 mRNA	16002434
C118739	entinostat	entinostat results in decreased expression of CRYBG3 mRNA	27188386
C039281	furan	furan results in increased expression of CRYBG3 mRNA	26194646
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRYBG3 mRNA	25613284
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of CRYBG3 mRNA"	24972896
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CRYBG3 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CRYBG3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CRYBG3 mRNA"	25620056
C029938	nickel sulfate	nickel sulfate results in decreased expression of CRYBG3 mRNA	22714537
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"	25510870
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CRYBG3 mRNA	27153767
D010634	Phenobarbital	Phenobarbital affects the expression of CRYBG3 mRNA	23091169
D010936	Plant Extracts	Plant Extracts results in increased expression of CRYBG3 mRNA	23557933
D011374	Progesterone	Progesterone results in increased expression of CRYBG3 mRNA	22238285
C009277	sodium arsenate	sodium arsenate results in increased expression of CRYBG3 mRNA	21795629
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CRYBG3 mRNA	27862939
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CRYBG3 protein	28918527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CRYBG3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CRYBG3 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CRYBG3 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRYBG3 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of CRYBG3 protein	24648495
D013853	Thioacetamide	Thioacetamide results in increased expression of CRYBG3 mRNA	23411599
D014212	Tretinoin	Tretinoin results in increased expression of CRYBG3 mRNA	23724009
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of CRYBG3 mRNA	29024780
D014520	Urethane	Urethane results in increased expression of CRYBG3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of CRYBG3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CRYBG3 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased expression of CRYBG3 mRNA	24896083
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CRYBG3 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0030246	carbohydrate binding	-	IEA	-
GO:0051018	protein kinase A binding	-	IPI	25097019

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008150	biological_process	-	ND	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0032991	protein-containing complex	-	IDA	25097019

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal