Gene: CRYBG3

131544
DKFZp667G2110|vlAKAP
crystallin beta-gamma domain containing 3
protein-coding
3q11.2
Ensembl:ENSG00000080200 Vega:OTTHUMG00000159187 UniprotKB:Q68DQ2
NC_000003.12
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.375e-1 (AD)  1.178e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1391665chr3:97914893 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4857068chr3:97903853 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1498652chr3:97901684 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6786354chr3:97876535 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3856567chr3:97864832 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs699300chr3:97847729 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1848035chr3:97823011 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBED60.833
CYP7B10.638
MKLN10.634
KIAA07540.627
NBEAL10.622
ZNF354C0.614
BBX0.607
HEATR5A0.598
USP370.596
ALMS10.596

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM54-0.438
AZU1-0.414
SPEF1-0.376
CYP4A11-0.373
TMEM191C-0.371
BEST4-0.369
PIP5KL1-0.366
PRTN3-0.362
CKMT1B-0.359
ADCK5-0.352

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CRYBG3 mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of CRYBG3 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of CRYBG3 mRNA28959563
C547126AZM551248AZM551248 results in decreased expression of CRYBG3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CRYBG3 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of CRYBG3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CRYBG3 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of CRYBG3 mRNA19549813
D002117CalcitriolCalcitriol results in increased expression of CRYBG3 mRNA16002434
C118739entinostatentinostat results in decreased expression of CRYBG3 mRNA27188386
C039281furanfuran results in increased expression of CRYBG3 mRNA26194646
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRYBG3 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CRYBG3 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CRYBG3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CRYBG3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CRYBG3 mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of CRYBG3 mRNA22714537
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CRYBG3 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CRYBG3 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of CRYBG3 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of CRYBG3 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of CRYBG3 mRNA22238285
C009277sodium arsenatesodium arsenate results in increased expression of CRYBG3 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of CRYBG3 mRNA27862939
D012969Sodium FluorideSodium Fluoride results in increased expression of CRYBG3 protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRYBG3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CRYBG3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CRYBG3 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CRYBG3 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of CRYBG3 protein24648495
D013853ThioacetamideThioacetamide results in increased expression of CRYBG3 mRNA23411599
D014212TretinoinTretinoin results in increased expression of CRYBG3 mRNA23724009
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CRYBG3 mRNA29024780
D014520UrethaneUrethane results in increased expression of CRYBG3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CRYBG3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CRYBG3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of CRYBG3 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CRYBG3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030246carbohydrate binding-IEA-  
GO:0051018protein kinase A binding-IPI25097019  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032991protein-containing complex-IDA25097019  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal