Gene: CPE

1363
CPH
carboxypeptidase E
protein-coding
4q32.3
Ensembl:ENSG00000109472 MIM:114855 Vega:OTTHUMG00000150252 UniprotKB:P16870
NC_000004.12
PubMed|SNP Mapped
7   ANCO-SNPs
OD|CD|ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.414e-3 (AD)  7.389e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1370687chr4:165469203 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6536915chr4:165463215 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs729699chr4:165414029 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17686882chr4:165401246 (GRCh38.p7)G>A / G>Tcocaine dependenceSNV(Single Nucleotide Variation)
rs35355030chr4:165394348 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs4691188chr4:165391348 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)
rs9631752chr4:165390534 (GRCh38.p7)A>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDAH10.947
TMBIM60.926
ITM2C0.92
ALDOC0.915
PGM10.912
SPARCL10.906
ZFYVE210.905
BBS20.904
GLUD10.904
SCG30.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.8
OR4F29-0.764
GADL1-0.306
CLEC6A-0.296
FER1L6-0.291
DPPA4-0.284
C2orf83-0.282
FCRL1-0.277
OR6C74-0.276
LY9-0.276

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00030Insulin HumanBiotechDrug11061-68-0Approved|InvestigationalTarget
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CPE mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CPE mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CPE mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of CPE mRNA"23829299
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CPE mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CPE mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
D000111AcetylcysteineAcetylcysteine results in decreased expression of CPE mRNA16084531
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CPE gene27153756
D019386AlendronateAlendronate affects the expression of CPE mRNA16079270
D001104ArbutinArbutin results in increased expression of CPE mRNA17103032
C006632arsenic trioxidearsenic trioxide results in decreased expression of CPE mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased expression of CPE mRNA22535156
D001280AtrazineAtrazine results in decreased expression of CPE mRNA25929836
D001374AzacitidineAzacitidine results in increased expression of CPE mRNA20823114
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPE mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPE mRNA19770486|2261060
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CPE mRNA"20382639
D004958EstradiolEstradiol affects the expression of CPE mRNA14699072
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CPE mRNA19619570
D004958EstradiolEstradiol results in increased expression of CPE mRNA19619570
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CPE mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CPE mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CPE mRNA12075121
C006780bisphenol Abisphenol A results in increased expression of CPE mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CPE mRNA12419474
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CPE mRNA15336504
C584509C646 compoundC646 compound results in increased expression of CPE mRNA26191083
D002104CadmiumCadmium results in increased expression of CPE mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CPE promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CPE mRNA17484886|2733941
C054133casticincasticin results in increased expression of CPE mRNA28444820
D002857ChromiumChromium results in decreased expression of CPE mRNA21437242
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CPE mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of CPE mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of CPE mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CPE mRNA25562108|2798913
C089595cylindrospermopsincylindrospermopsin results in decreased expression of CPE mRNA24921660
C515055darinaparsindarinaparsin results in increased expression of CPE mRNA22535156
C515055darinaparsinOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CPE mRNA]22535156
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CPE mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of CPE mRNA alternative form25426952
D003907DexamethasoneDexamethasone results in decreased expression of CPE mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CPE mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CPE mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CPE mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CPE mRNA27392435
D002945CisplatinCisplatin results in increased expression of CPE mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CPE mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of CPE mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPE mRNA18164116
D004237DiuronDiuron results in decreased expression of CPE mRNA21551480
C104705dopamine quinonedopamine quinone results in decreased activity of CPE protein21540292
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of CPE mRNA16084531
D000431EthanolEthanol results in decreased expression of CPE mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CPE mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CPE mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CPE mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CPE mRNA16079270|1735126
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CPE mRNA12075121|1617478
D005419FlavonoidsFlavonoids results in increased expression of CPE mRNA18035473
D005472FluorouracilCPE protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilFluorouracil results in increased expression of CPE protein15352031
D004397FonofosFonofos results in increased methylation of CPE promoter22847954
C039281furanfuran results in decreased methylation of CPE gene27387713
C039281furanfuran results in increased expression of CPE mRNA27387713
D019833GenisteinGenistein results in decreased expression of CPE mRNA12075121
D017313FenretinideFenretinide results in increased expression of CPE mRNA28973697
C492448ICG 001ICG 001 results in increased expression of CPE mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CPE mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of CPE mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CPE mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of CPE mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CPE mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CPE mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CPE mRNA27392435
C011890kojic acidkojic acid results in increased expression of CPE mRNA16595896
D007854LeadLead affects the expression of CPE mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CPE mRNA"11578593
D015122MercaptopurineMercaptopurine results in increased expression of CPE mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of CPE mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
D016210Methacholine ChlorideCPE gene mutant form results in increased susceptibility to Methacholine Chloride16002559
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CPE mRNA28001369
D015735MifepristoneMifepristone results in decreased expression of CPE mRNA25972201
D009020MorphineMorphine results in increased expression of CPE mRNA20144693
C523799MRK 003MRK 003 results in decreased expression of CPE mRNA21169257
C523799MRK 003CPE results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPE mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CPE mRNA"25554681
D009532NickelNickel results in decreased expression of CPE mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of CPE mRNA22714537
D009638NorepinephrineNorepinephrine results in decreased activity of CPE protein21540292
D009943Organophosphorus CompoundsOrganophosphorus Compounds results in decreased activity of CPE protein17955620
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CPE mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CPE mRNA25729387
D010100OxygenOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CPE mRNA]22535156
D010126OzoneCPE affects the susceptibility to Ozone23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of CSF3 protein23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of CXCL1 protein23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of IL13 mRNA23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of IL17A mRNA23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of IL5 mRNA23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of IL6 protein23434795
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of TNF protein23434795
D010126OzoneCPE gene mutant form promotes the reaction [Ozone results in increased expression of CCL2 protein]16002559
D010126OzoneCPE gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]16002559
D010126OzoneCPE gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 protein]16002559
D010126OzoneCPE gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein]16002559
D010126OzoneCPE gene mutant form results in increased susceptibility to Ozone16002559
D010126OzoneOzone results in decreased expression of CPE mRNA12763052
D010126OzoneTNFRSF1B affects the reaction [CPE affects the susceptibility to Ozone]23434795
D010126OzoneTNFRSF1B affects the reaction [[CPE affects the susceptibility to Ozone] which affects the expression of IL5 mRNA]23434795
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CPE mRNA26272509
D010278ParathionParathion results in increased methylation of CPE promoter22847954
D010575PesticidesPesticides results in decreased activity of CPE protein17955620
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CPE mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CPE mRNA19482888|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CPE mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of CPE mRNA15728792
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CPE mRNA22714537
C045950propiconazolepropiconazole results in increased expression of CPE mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CPE mRNA16079270
D012110ReserpineReserpine results in increased activity of CPE protein21540292
D012110ReserpineReserpine results in increased expression of CPE mRNA8189248
C059514resveratrolresveratrol results in increased expression of CPE mRNA23419489
D012715Sesame OilSesame Oil results in increased expression of CPE mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CPE mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CPE mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CPE mRNA25351596
D013629TamoxifenTamoxifen affects the expression of CPE mRNA14699072
D013629TamoxifenTamoxifen affects the expression of CPE mRNA17555576
C012568terbufosterbufos results in increased methylation of CPE promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CPE mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CPE mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPE mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CPE mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CPE mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of CPE mRNA23409001|2355797
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CPE mRNA25729387
D019772TopotecanTopotecan results in increased expression of CPE mRNA25729387
D014212TretinoinTretinoin results in increased expression of CPE mRNA21934132
D014212TretinoinTretinoin results in increased expression of CPE mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CPE mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CPE mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CPE mRNA23179753|2352703
D014640VancomycinVancomycin results in decreased expression of CPE mRNA18930951
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPE mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CPE mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004180carboxypeptidase activity-TAS9019408  
GO:0004181metallocarboxypeptidase activity-IBA21873635  
GO:0004181metallocarboxypeptidase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO:0042043neurexin family protein binding-IPI19166515  
GO:0050839cell adhesion molecule binding-IPI19166515  
GO ID GO Term Qualifier Evidence PubMed
GO:0003214cardiac left ventricle morphogenesis-IMP19593212  
GO:0006464cellular protein modification process-NAS2334405  
GO:0006518peptide metabolic process-IBA21873635  
GO:0007218neuropeptide signaling pathway-NAS2334405  
GO:0016055Wnt signaling pathway-IDA22824791  
GO:0016485protein processing-IBA21873635  
GO:0030070insulin processing-IBA21873635  
GO:0072657protein localization to membrane-IDA19166515  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA19166515  
GO:0005886plasma membrane-TAS9019408  
GO:0030141secretory granule-IBA21873635  
GO:0030658transport vesicle membrane-IEA-  
GO:0030667secretory granule membrane-TAS-  
GO:0043025neuronal cell body-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
GO:0097060synaptic membrane-IBA21873635  
KEGG ID KEGG Term
hsa04940Type I diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res
23866471Is there any benefit of preoperative oral trimetazidine in coronary artery bypass graft? (2012 Dec)Sher-i-Murtaza MJ Pak Med Assoc
26410020Pre-treatment tumor-specific growth rate as a temporal biomarker that predicts treatment failure and improves risk stratification for oropharyngeal cancer. (2015 Nov)Murphy CTOral Oncol