Gene: SESN3

143686
SEST3
sestrin 3
protein-coding
11q21
Ensembl:ENSG00000149212 MIM:607768 Vega:OTTHUMG00000167829 UniprotKB:P58005
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
2.088e-1 (AD)  1.727e-1 (ND)   (Frontal_Cortex)
6.480e-1 (AD)  9.348e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs646667chr11:95182814 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS2ST10.849
CREBL20.836
KLHL230.836
ARHGEF120.834
UNC119B0.829
EGLN10.825
CCNG20.825
FAM199X0.82
NCOA20.812
CDH20.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.684
OR4F29-0.631
NANOGNB-0.273
ANXA13-0.272
FXYD4-0.265
KEL-0.256
TRPV5-0.256
GNG8-0.247
SFN-0.243
TNFRSF13B-0.241

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SESN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SESN3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SESN3 mRNA25458485
D000082AcetaminophenAcetaminophen results in decreased expression of SESN3 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of SESN3 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of SESN3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SESN3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SESN3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SESN3 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SESN3 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of SESN3 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SESN3 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SESN3 mRNA21298039
C487081belinostatbelinostat results in increased expression of SESN3 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SESN3 mRNA21569818
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SESN3 mRNA20660070
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SESN3 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SESN3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SESN3 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SESN3 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SESN3 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of SESN3 mRNA29097150
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SESN3 mRNA20147733
D002104CadmiumCadmium results in decreased expression of SESN3 mRNA21120746
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SESN3 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SESN3 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SESN3 mRNA20938992
D016572CyclosporineCyclosporine results in decreased expression of SESN3 mRNA20106945|2163298
D002945CisplatinCisplatin results in decreased expression of SESN3 mRNA27594783
D004147DioxinsDioxins affects the expression of SESN3 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SESN3 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SESN3 mRNA20938992
C039281furanfuran results in increased expression of SESN3 mRNA25539665
C001277geldanamycingeldanamycin results in increased expression of SESN3 mRNA26705709
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SESN3 mRNA24763279
D017313FenretinideFenretinide results in decreased expression of SESN3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SESN3 mRNA29274434
D006861Hydrogen PeroxideSaponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SESN3 mRNA]29274434
C016517indole-3-carbinolindole-3-carbinol affects the expression of SESN3 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SESN3 mRNA25613284
D007501IronIron deficiency results in decreased expression of SESN3 mRNA20368581
C544151jinfukangjinfukang results in decreased expression of SESN3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SESN3 mRNA21889194|2194939
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SESN3 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of SESN3 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SESN3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SESN3 mRNA26272509|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SESN3 mRNA26011545
D015735MifepristoneMifepristone results in increased expression of SESN3 mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SESN3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SESN3 mRNA"25554681|2562005
C000605331OTX015OTX015 results in increased expression of SESN3 mRNA27388964
C016030pantogabpantogab results in decreased expression of SESN3 mRNA17379144
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SESN3 mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SESN3 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of SESN3 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of SESN3 mRNA21632981
C031389resorcinolresorcinol results in decreased expression of SESN3 mRNA22623647
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SESN3 mRNA21427059
D012503SaponinsSaponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SESN3 mRNA]29274434
C410733scriptaidscriptaid affects the expression of SESN3 mRNA18813790
D019821SimvastatinSimvastatin results in decreased expression of SESN3 mRNA20883752
C009277sodium arsenatesodium arsenate results in decreased expression of SESN3 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of SESN3 mRNA21795629
D012999SomanSoman results in increased expression of SESN3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SESN3 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SESN3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SESN3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SESN3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SESN3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SESN3 mRNA25613284
D014112ToxapheneToxaphene results in increased expression of SESN3 mRNA23153324
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of SESN3 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of SESN3 mRNA20530235
C012589trichostatin Atrichostatin A results in increased expression of SESN3 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of SESN3 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of SESN3 mRNA26272509
C057693troglitazonetroglitazone results in decreased expression of SESN3 mRNA17569031
D014520UrethaneUrethane results in increased expression of SESN3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of SESN3 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SESN3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SESN3 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of SESN3 mRNA23179753|2571616
D014635Valproic AcidValproic Acid results in increased expression of SESN3 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SESN3 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of SESN3 mRNA26682919
C111237vorinostatvorinostat results in increased expression of SESN3 mRNA27188386
D019287Zinc SulfateZinc Sulfate results in decreased expression of SESN3 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25263562  26449471  
GO:0016491oxidoreductase activity-IEA-  
GO:0016684oxidoreductase activity, acting on peroxide as acceptor-IBA21873635  
GO:0070728leucine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0016239positive regulation of macroautophagy-IBA21873635  
GO:0032868response to insulin-IEA-  
GO:0034198cellular response to amino acid starvation-IMP25263562  
GO:0038203TORC2 signaling-IEA-  
GO:0042149cellular response to glucose starvation-IMP25263562  
GO:0042593glucose homeostasis-IEA-  
GO:0046626regulation of insulin receptor signaling pathway-IEA-  
GO:0051896regulation of protein kinase B signaling-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0071230cellular response to amino acid stimulus-IBA21873635  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO:0071233cellular response to leucine-IBA21873635  
GO:1901031regulation of response to reactive oxygen species-IEA-  
GO:1904262negative regulation of TORC1 signaling-IBA21873635  
GO:1904262negative regulation of TORC1 signaling-IMP25263562  
GO:1990253cellular response to leucine starvation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IDA25263562  
GO:0031932TORC2 complexCOLOCALIZES_WITHIBA21873635  
GO:0031932TORC2 complex-IEA-  
GO:0061700GATOR2 complexCOLOCALIZES_WITHIBA21873635  
GO:0061700GATOR2 complexcolocalizes_withIDA25263562  26449471  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal