Gene: CSNK1G3

1456
CKI-gamma 3|CSNK1G3L
casein kinase 1 gamma 3
protein-coding
5q23.2
Ensembl:ENSG00000151292 MIM:604253 Vega:OTTHUMG00000128923 UniprotKB:Q9Y6M4
NC_000005.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.802e-1 (AD)  7.157e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1579036chr5:123585409 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTF3L40.952
MTMR60.949
NUDT210.945
SHOC20.944
APPL10.943
DNAJB140.943
SLC25A460.942
KLHL70.942
ATE10.941
HSPA130.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.536
CSAG1-0.367
ANPEP-0.321
MTRNR2L10-0.317
S100A14-0.311
MTRNR2L6-0.304
KCNK5-0.286
NXNL1-0.285
S100A1-0.284

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04751Purvalanol ASmall Molecule212844-53-6ExperimentalTarget
DB07488{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONESmall MoleculeExperimentalTarget
DB074894-Amino-2-[(3-chlorophenyl)amino]-5-(4-fluorobenzoyl)-1,3-thiazol-3-iumSmall MoleculeExperimentalTarget
DB076645-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CSNK1G3 mRNA"21346803
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of CSNK1G3 mRNA19643169
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CSNK1G3 mRNA16483693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CSNK1G3 mRNA"19150397|2001819
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CSNK1G3 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of CSNK1G3 mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of CSNK1G3 mRNA21179406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CSNK1G3 mRNA21297351
D002118CalciumCalcium affects the expression of CSNK1G3 mRNA15913539
D019327Copper SulfateCopper Sulfate results in increased expression of CSNK1G3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of CSNK1G3 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of CSNK1G3 mRNA25562108
C014347decitabinedecitabine results in decreased expression of CSNK1G3 mRNA27915011
C014347decitabinedecitabine results in decreased methylation of CSNK1G3 gene27923600
C000944dicrotophosdicrotophos results in decreased expression of CSNK1G3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of CSNK1G3 mRNA25016146
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSNK1G3 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of CSNK1G3 mRNA28189721
D005485FlutamideFlutamide results in increased expression of CSNK1G3 mRNA24136188
C039281furanfuran results in increased expression of CSNK1G3 mRNA24183702
D005839GentamicinsGentamicins results in increased expression of CSNK1G3 mRNA22061828
D017313FenretinideFenretinide results in increased expression of CSNK1G3 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of CSNK1G3 mRNA27392435
C045463leflunomideleflunomide results in increased expression of CSNK1G3 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CSNK1G3 mRNA"20188158
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CSNK1G3 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of CSNK1G3 mRNA23557933
D012969Sodium FluorideSodium Fluoride results in decreased expression of CSNK1G3 mRNA21340527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSNK1G3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CSNK1G3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CSNK1G3 mRNA21354282
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CSNK1G3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CSNK1G3 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CSNK1G3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CSNK1G3 mRNA28973697
D014520UrethaneUrethane results in increased expression of CSNK1G3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CSNK1G3 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CSNK1G3 gene25560391
C025643vinclozolinvinclozolin affects the expression of CSNK1G3 mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of CSNK1G3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS9925945  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA25500533  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-TAS9925945  
GO:0006897endocytosis-IBA21873635  
GO:0007165signal transduction-TAS9925945  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA25500533  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa04340Hedgehog signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal