Gene: FAM81A

145773
-
family with sequence similarity 81 member A
protein-coding
15q22.2
Ensembl:ENSG00000157470 Vega:OTTHUMG00000171915 UniprotKB:Q8TBF8
NC_000015.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.265e-1 (AD)  2.567e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7164726chr15:59423467 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10519005chr15:59419492 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRA10.966
DLGAP10.963
RBFOX10.962
PRKCE0.961
GABRB20.959
CNTNAP20.958
FGF120.958
CREG20.957
SYT130.957
MEF2C0.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.558
RAI14-0.541
CNN2-0.537
HEY2-0.535
WWTR1-0.522
RUNX3-0.512
PGF-0.508
CMTM3-0.507
RAB13-0.507
RNF135-0.506

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM81A gene27153756
D000638AmiodaroneAmiodarone results in increased expression of FAM81A mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM81A mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM81A mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of FAM81A mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of FAM81A mRNA25594700
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of FAM81A mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of FAM81A mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of FAM81A mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FAM81A mRNA27339419
D004390ChlorpyrifosChlorpyrifos results in increased expression of FAM81A mRNA18668222
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FAM81A mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of FAM81A mRNA21865292
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA"18606552
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of FAM81A mRNA28962523
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FAM81A mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of FAM81A mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of FAM81A mRNA21592394
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FAM81A mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of FAM81A mRNA23649840
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA"18606552
D017313FenretinideFenretinide results in increased expression of FAM81A mRNA28973697
C544151jinfukangjinfukang results in increased expression of FAM81A mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FAM81A mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM81A mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of FAM81A mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FAM81A mRNA20971185
C046012pentanalpentanal results in increased expression of FAM81A mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of FAM81A mRNA23602845
D010634PhenobarbitalPhenobarbital results in decreased expression of FAM81A mRNA19270015
D011374ProgesteroneProgesterone results in decreased expression of FAM81A mRNA23018184
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of FAM81A mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of FAM81A mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of FAM81A mRNA26496021
C009495titanium dioxidetitanium dioxide results in decreased expression of FAM81A mRNA23557971
D014212TretinoinTretinoin results in decreased expression of FAM81A mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FAM81A mRNA"26179874
C025643vinclozolinvinclozolin affects the expression of FAM81A mRNA19015723
D014750VincristineVincristine results in decreased expression of FAM81A mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal