Gene: RTN4RL1

146760
NGRH2|NgR3
reticulon 4 receptor like 1
protein-coding
17p13.3
Ensembl:ENSG00000185924 MIM:610461 Vega:OTTHUMG00000180184 UniprotKB:Q86UN2
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.651e-1 (AD)  3.482e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4525524chr17:1941577 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08457620chr17:1900131RTN4RL1Gene body5.524e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AACS0.951
LRFN20.948
DOC2A0.948
RAB150.947
KCNB10.946
KCNC10.945
ENC10.944
MICAL20.942
LINGO10.941
SLC8A20.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.617
YES1-0.616
REST-0.605
MBNL3-0.57
WWTR1-0.566
RAI14-0.564
MYL3-0.561
LRAT-0.559
COPZ2-0.555
SNHG18-0.554

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RTN4RL1 mRNA"28903501
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RTN4RL1 mRNA19933214
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of RTN4RL1 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RTN4RL1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RTN4RL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RTN4RL1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RTN4RL1 mRNA17562736
D000447AldehydesAldehydes results in increased expression of RTN4RL1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RTN4RL1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RTN4RL1 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of RTN4RL1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of RTN4RL1 mRNA26079696
D002922CiguatoxinsCiguatoxins affects the expression of RTN4RL1 mRNA18353800
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of RTN4RL1 mRNA19524605
C018021cobaltous chloridecobaltous chloride results in decreased expression of RTN4RL1 mRNA24386269
D003300CopperCopper results in decreased expression of RTN4RL1 mRNA24403277
D019327Copper SulfateCopper Sulfate results in increased expression of RTN4RL1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of RTN4RL1 mRNA27523638
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RTN4RL1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RTN4RL1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RTN4RL1 mRNA27392435
D004221DisulfiramDisulfiram results in decreased expression of RTN4RL1 mRNA20530235
D004237DiuronDiuron results in decreased expression of RTN4RL1 mRNA21551480
C069837fullerene C60fullerene C60 results in increased expression of RTN4RL1 mRNA19167457
C039281furanfuran results in decreased expression of RTN4RL1 mRNA26194646
D017313FenretinideFenretinide results in decreased expression of RTN4RL1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of RTN4RL1 mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RTN4RL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RTN4RL1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RTN4RL1 mRNA27392435
D007854LeadLead affects the expression of RTN4RL1 mRNA22313790
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RTN4RL1 mRNA25890327
D015122MercaptopurineMercaptopurine results in increased expression of RTN4RL1 mRNA23358152
D008694MethamphetamineMethamphetamine results in increased expression of RTN4RL1 mRNA28341135
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RTN4RL1 mRNA"25620056
C028007nickel monoxidenickel monoxide affects the expression of RTN4RL1 mRNA19167457
C410127PCB 180PCB 180 results in decreased expression of RTN4RL1 mRNA23829299
C046012pentanalpentanal results in increased expression of RTN4RL1 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of RTN4RL1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of RTN4RL1 mRNA19270015
C045950propiconazolepropiconazole results in decreased expression of RTN4RL1 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of RTN4RL1 mRNA26079696
D012312RitodrineRitodrine results in decreased expression of RTN4RL1 mRNA23370008
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RTN4RL1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RTN4RL1 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RTN4RL1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RTN4RL1 mRNA26290441|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RTN4RL1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RTN4RL1 mRNA15358164
D014212TretinoinTretinoin results in decreased expression of RTN4RL1 mRNA20530235
C012589trichostatin Atrichostatin A results in decreased expression of RTN4RL1 mRNA24935251
D014520UrethaneUrethane results in decreased expression of RTN4RL1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of RTN4RL1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RTN4RL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RTN4RL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RTN4RL1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of RTN4RL1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RTN4RL1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008201heparin binding-ISS-  
GO:0035374chondroitin sulfate binding-ISS-  
GO:0038023signaling receptor activity-IDA12694398  
GO ID GO Term Qualifier Evidence PubMed
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0022038corpus callosum development-IEA-  
GO:0031103axon regeneration-TAS14664809  
GO:0048681negative regulation of axon regeneration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0009986cell surface-IDA20463223  
GO:0042995cell projection-IEA-  
GO:0043204perikaryon-IEA-  
GO:0045121membrane raft-IEA-  
GO:0046658anchored component of plasma membrane-IDA12694398  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal