Gene info: ID 147837

Gene: ZNF563

GENE ID: 147837

Synonyms: -

Description: zinc finger protein 563

Gene type: protein-coding

Location: 19p13.2

dbXrefs: Ensembl:ENSG00000188868 Vega:OTTHUMG00000156413 UniprotKB:Q8TA94

RefSeq: NC_000019.10

Retrived from: SNP Mapped

SNPs: 4 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.387e-1 (AD) 8.046e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs9676962	chr19:12330430 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1593000	chr19:12329054 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs12610507	chr19:12325596 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs7246738	chr19:12324088 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FAM114A2	0.637
ZNF627	0.628
ZMYM5	0.627
ZNF700	0.62
RBM12	0.618
PTBP3	0.606
POT1	0.605
RIPK2	0.604
CCNT1	0.603
EOGT	0.603

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.316
OR4F29	-0.302
HES5	-0.245
NEU4	-0.227
MBD3L3	-0.195
HPR	-0.186
PTGDR2	-0.171
PRM3	-0.168
OR6F1	-0.161
WFIKKN1	-0.158

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in increased expression of ZNF563 mRNA	26690555
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ZNF563 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of ZNF563 gene	25435355
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ZNF563 mRNA	19549813
C000944	dicrotophos	dicrotophos results in decreased expression of ZNF563 mRNA	28302478
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ZNF563 mRNA	27153767
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ZNF563 mRNA	23806026
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ZNF563 mRNA	29024780

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal