Gene: ADRA1A

148
ADRA1C|ADRA1L1|ALPHA1AAR
adrenoceptor alpha 1A
protein-coding
8p21.2
Ensembl:ENSG00000120907 MIM:104221 Vega:OTTHUMG00000099459 UniprotKB:P35348
NG_029395.1
PubMed|SNP Mapped
CD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.813e-1 (AD)  6.871e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4732900chr8:26820138 (GRCh38.p7)T>A / T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17963840chr8:26722861ADRA1APromoter1.040e-4Alcohol use disorders26763658
cg21230493chr8:26722496ADRA1APromoter3.422e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRB10.734
GPR750.687
EFR3B0.675
PCDHGA50.662
PCDHGA40.653
PCDHGA20.65
PCDHGB10.644
SOX50.641
ZNF7100.634
CHRDL10.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG8-0.322
FAM178B-0.32
TSPAN8-0.319
CYB5R2-0.315
ITIH1-0.315
NINJ2-0.307
FXYD4-0.307
NRN1L-0.303
GPR42-0.294
CDKN1C-0.294

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00211MidodrineSmall Molecule42794-76-3ApprovedTarget
DB00215CitalopramSmall Molecule59729-33-8ApprovedTarget
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00298DapiprazoleSmall Molecule72822-12-9ApprovedTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00346AlfuzosinSmall Molecule81403-80-7Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00368NorepinephrineSmall Molecule51-41-2ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00388PhenylephrineSmall Molecule59-42-7ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00420PromazineSmall Molecule58-40-2ApprovedTarget
DB00449DipivefrinSmall Molecule52365-63-6ApprovedTarget
DB00450DroperidolSmall Molecule548-73-2ApprovedTarget
DB00457PrazosinSmall Molecule19216-56-9ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00540NortriptylineSmall Molecule72-69-5ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00575ClonidineSmall Molecule4205-90-7ApprovedTarget
DB00590DoxazosinSmall Molecule74191-85-8ApprovedTarget
DB00610MetaraminolSmall Molecule54-49-9Approved|InvestigationalTarget
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalTarget
DB00656TrazodoneSmall Molecule19794-93-5Approved|InvestigationalTarget
DB00661VerapamilSmall Molecule52-53-9ApprovedTarget
DB00668EpinephrineSmall Molecule51-43-4ApprovedTarget
DB00679ThioridazineSmall Molecule50-52-2Approved|WithdrawnTarget
DB00692PhentolamineSmall Molecule50-60-2ApprovedTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00699NicergolineSmall Molecule27848-84-6Approved|InvestigationalTarget
DB00706TamsulosinSmall Molecule106133-20-4Approved|InvestigationalTarget
DB00723MethoxamineSmall Molecule390-28-3Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00734RisperidoneSmall Molecule106266-06-2Approved|InvestigationalTarget
DB00751EpinastineSmall Molecule80012-43-7Approved|InvestigationalTarget
DB00777PropiomazineSmall Molecule362-29-8ApprovedTarget
DB00797TolazolineSmall Molecule59-98-3ApprovedTarget
DB00800FenoldopamSmall Molecule67227-56-9ApprovedTarget
DB00831TrifluoperazineSmall Molecule117-89-5Approved|InvestigationalTarget
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
DB00865BenzphetamineSmall Molecule156-08-1Approved|IllicitTarget
DB00875FlupentixolSmall Molecule2709-56-0Approved|Investigational|WithdrawnTarget
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalTarget
DB00925PhenoxybenzamineSmall Molecule59-96-1ApprovedTarget
DB00935OxymetazolineSmall Molecule1491-59-4Approved|InvestigationalTarget
DB00964ApraclonidineSmall Molecule66711-21-5ApprovedTarget
DB01069PromethazineSmall Molecule60-87-7Approved|InvestigationalTarget
DB01136CarvedilolSmall Molecule72956-09-3Approved|InvestigationalTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01149NefazodoneSmall Molecule83366-66-9Approved|WithdrawnTarget
DB01162TerazosinSmall Molecule63590-64-7ApprovedTarget
DB01175EscitalopramSmall Molecule128196-01-0Approved|InvestigationalTarget
DB01186PergolideSmall Molecule66104-22-1Approved|Investigational|WithdrawnTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01253ErgonovineSmall Molecule60-79-7ApprovedTarget
DB01267PaliperidoneSmall Molecule144598-75-4ApprovedTarget
DB01295BevantololSmall Molecule59170-23-9ApprovedTarget
DB01364EphedrineSmall Molecule299-42-3ApprovedTarget
DB01403MethotrimeprazineSmall Molecule60-99-1Approved|InvestigationalTarget
DB014724-MethoxyamphetamineSmall Molecule64-13-1Experimental|IllicitTarget
DB01576DextroamphetamineSmall Molecule51-64-9Approved|IllicitTarget
DB01579PhendimetrazineSmall Molecule634-03-7Approved|IllicitTarget
DB01614AcepromazineSmall Molecule61-00-7ApprovedTarget
DB01622ThioproperazineSmall Molecule316-81-4ApprovedTarget
DB01624ZuclopenthixolSmall Molecule53772-83-1Approved|InvestigationalTarget
DB04855DronedaroneSmall Molecule141626-36-0ApprovedTarget
DB04946IloperidoneSmall Molecule133454-47-4ApprovedTarget
DB05469R450Small Molecule-InvestigationalTarget
DB05492Epicept NP-1Small Molecule-InvestigationalTarget
DB06144SertindoleSmall Molecule106516-24-9Approved|Investigational|WithdrawnTarget
DB06207SilodosinSmall Molecule160970-54-7ApprovedTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB06229OcaperidoneSmall Molecule129029-23-8InvestigationalTarget
DB06262DroxidopaSmall Molecule23651-95-8Approved|InvestigationalTarget
DB06694XylometazolineSmall Molecule526-36-3Approved|InvestigationalTarget
DB06706IsomethepteneSmall Molecule503-01-5ApprovedTarget
DB06711NaphazolineSmall Molecule835-31-4ApprovedTarget
DB06764TetryzolineSmall Molecule84-22-0ApprovedTarget
DB08950IndoraminSmall Molecule26844-12-2WithdrawnTarget
DB09202CirazolineSmall Molecule59939-16-1ExperimentalTarget
DB09239NiguldipineSmall Molecule113165-32-5ExperimentalTarget
DB11124RacepinephrineSmall Molecule329-65-7ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00598LabetalolSmall Molecule36894-69-6ApprovedTarget
DB00934MaprotilineSmall Molecule10262-69-8Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB08922PerospironeSmall Molecule150915-41-6ApprovedTarget
DB09167DosulepinSmall Molecule113-53-1ApprovedTarget
DB09194EtoperidoneSmall Molecule52942-31-1WithdrawnTarget
DB09195LorpiprazoleSmall Molecule108785-69-9ApprovedTarget
DB09203SynephrineSmall Molecule94-07-5ExperimentalTarget
DB09204ArotinololSmall Molecule68377-92-4InvestigationalTarget
DB09286PipamperoneSmall Molecule1893-33-0Approved|InvestigationalTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTarget
DB01365MephentermineSmall Molecule100-92-5ApprovedTarget
DB09205MoxisylyteSmall Molecule54-32-0Approved|InvestigationalTarget
DB09229AranidipineSmall Molecule86780-90-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0990601-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]11937776
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]"15550506
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]"15550506
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to ADRA1A protein"8183249
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane results in decreased activity of ADRA1A protein"11306708
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to and results in decreased activity of ADRA1A protein"16822496|8773445
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane results in decreased activity of ADRA1A protein"7909562
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C0480082-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone binds to ADRA1A protein9570190
C0480082-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone binds to ADRA1A protein9639061
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADRA1A mRNA"18648102
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C0574465-methylurapidil5-methylurapidil binds to ADRA1A protein9294627
C0574465-methylurapidil5-methylurapidil binds to ADRA1A protein21544540|8183249
C0574465-methylurapidil5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]16498073
C0574465-methylurapidil5-methylurapidil results in decreased activity of ADRA1A protein16498073
C0574465-methylurapidil5-methylurapidil inhibits the reaction [ADRA1A protein results in increased susceptibility to Phenylephrine]18604236
C0574465-methylurapidil5-methylurapidil binds to and results in decreased activity of ADRA1A protein15872040|1595134
C0574465-methylurapidil5-methylurapidil inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
C0574465-methylurapidil5-methylurapidil results in decreased activity of ADRA1A protein11306708
C0574465-methylurapidil5-methylurapidil binds to and results in decreased activity of ADRA1A protein7913781|8816361
C094643A 61603A 61603 results in increased activity of ADRA1A protein16498073
C094643A 61603[A 61603 results in increased activity of ADRA1A protein] which results in increased abundance of Calcium16498073
C094643A 61603A 61603 binds to and results in increased activity of ADRA1A protein10381812|1587204
C094643A 61603ADRA1A protein results in increased susceptibility to A 6160315877108
C058534abanoquilabanoquil binds to ADRA1A protein8183249
D000082AcetaminophenAcetaminophen results in decreased expression of ADRA1A mRNA29067470
C047638alfuzosinalfuzosin binds to ADRA1A protein9294627
C047638alfuzosinalfuzosin binds to ADRA1A protein21544540|7536677
C047638alfuzosinalfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]8196478
C047638alfuzosinalfuzosin binds to ADRA1A protein7536677
C047638alfuzosinalfuzosin binds to and results in decreased activity of ADRA1A protein20126606|7913781
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADRA1A mRNA16483693
C015001arsenitearsenite results in increased methylation of ADRA1A promoter23974009
D001464BariumADRA1A protein promotes the reaction [TRPC6 protein results in increased transport of Barium]11179201
C010652BE 2254sertindole inhibits the reaction [BE 2254 binds to ADRA1A protein]11596272
C006780bisphenol Abisphenol A results in increased expression of ADRA1A mRNA25594700
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ADRA1A promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of ADRA1A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADRA1A gene28505145
C053428BMY 7378BMY 7378 binds to [ADRA1A protein binds to ADRA1D protein]16195468
C053428BMY 7378BMY 7378 inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D002065BuspironeBuspirone binds to and results in decreased activity of ADRA1A protein16545797
C018475butyraldehydebutyraldehyde results in increased expression of ADRA1A mRNA26079696
D002118Calcium5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]16498073
D002118Calcium[A 61603 results in increased activity of ADRA1A protein] which results in increased abundance of Calcium16498073
D002118Calciumcarvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D002118Calciumcarvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D002118Calcium[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium20030735
D002118Calcium[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium15306222
D002118Calcium[Norepinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium20030735
D002118Calcium[Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium20030735
D002118CalciumPhentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D002118CalciumPhentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D002118Calcium[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium15306222|1649807
D002118CalciumADRA1A protein affects the transport of Calcium15639650
D002118CalciumCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]12935885
D002118CalciumCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D002118CalciumCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]12935885
D002118Calcium[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium15672411
D002118Calcium[Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium15672411
C043211carvedilolcarvedilol binds to and results in decreased activity of ADRA1A protein15306222
C043211carvedilolcarvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
C043211carvedilolcarvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]15306222
C043211carvedilolcarvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]15306222
C043211carvedilolcarvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
C043211carvedilolcarvedilol results in decreased expression of ADRA1A mRNA20668454
C051731chlorethylclonidine[chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
C051731chlorethylclonidinechlorethylclonidine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D002746ChlorpromazineChlorpromazine results in decreased activity of ADRA1A protein23611293
D004390ChlorpyrifosChlorpyrifos affects the expression of ADRA1A mRNA18812211
D004390ChlorpyrifosChlorpyrifos results in decreased expression of ADRA1A mRNA17452286
C014282cirazoline"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]"15550506
C014282cirazoline"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]"15550506
C014282cirazoline2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C014282cirazoline2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C014282cirazoline4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C014282cirazolineADRA1A protein promotes the reaction [cirazoline results in increased expression of NPPA protein]18378355
C014282cirazolinecirazoline binds to and results in increased activity of ADRA1A protein15550506
C014282cirazoline[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose15550506
C014282cirazolinePrazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C014282cirazolinecirazoline binds to and results in increased activity of ADRA1A protein1685570
D003024ClozapineClozapine binds to and results in decreased activity of ADRA1A protein16545797
D005576Colforsin[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]19419905
D016572CyclosporineCyclosporine results in decreased expression of ADRA1A mRNA20106945
D003671DEETDEET results in decreased expression of ADRA1A mRNA27091632
D003671DEET[fipronil co-treated with DEET] results in decreased expression of ADRA1A mRNA27091632
D003976DiazinonDiazinon results in decreased expression of ADRA1A mRNA17452286
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ADRA1A promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADRA1A mRNA15620428
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ADRA1A mRNA28962523
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ADRA1A promoter23359474
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ADRA1A mRNA15620428
D017292DoxazosinDoxazosin binds to ADRA1A protein9294627
D017292DoxazosinDoxazosin binds to ADRA1A protein21544540|7536677
D017292DoxazosinDoxazosin binds to ADRA1A protein7536677
D017292DoxazosinDoxazosin binds to and results in decreased activity of ADRA1A protein16007219|2012660
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ADRA1A mRNA"23811387
D004726EndosulfanEndosulfan results in increased expression of ADRA1A protein26615145
D004837Epinephrinecarvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D004837EpinephrineEpinephrine binds to ADRA1A protein8183249
D004837EpinephrineEpinephrine binds to and results in increased activity of ADRA1A protein20030735
D004837Epinephrine[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium20030735
D004837EpinephrineEpinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D004837EpinephrineEpinephrine results in increased activity of ADRA1A protein15306222
D004837Epinephrine[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium15306222
D004837EpinephrinePhentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D004837EpinephrineEpinephrine binds to and results in increased activity of ADRA1A protein15672411
D004837Epinephrine[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium15672411
D000431EthanolEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]12935885
D000431EthanolEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D000431EthanolEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]12935885
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of ADRA1A mRNA27091632
C082360fipronilfipronil results in decreased expression of ADRA1A mRNA27091632
D005947Glucose"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]"15550506
D005947Glucose"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]"15550506
D005947Glucose2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
D005947Glucose2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
D005947Glucose4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
D005947Glucose[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose15550506
D005947Glucose[Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose15550506
D005947GlucosePrazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
C090701GR 127935GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D017829GranisetronGranisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [AGT protein results in increased expression of ADRA1A mRNA]7900855
D006418HemeHeme metabolite results in increased expression of ADRA1A mRNA19191707
C027299hydroxymaprotilinhydroxymaprotilin promotes the reaction [Phenylephrine binds to ADRA1A protein]2158798
D007217IndoraminIndoramin binds to ADRA1A protein7536677|8183249
D007217IndoraminIndoramin binds to ADRA1A protein7536677
D007217IndoraminIndoramin results in decreased activity of ADRA1A protein3955309
D0150561-Methyl-3-isobutylxanthine[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]19419905
C554161JB-788JB-788 binds to ADRA1A protein20580787
D007650KetanserinKetanserin inhibits the reaction [Prazosin binds to ADRA1A protein]11937776
D007650KetanserinKetanserin binds to and results in decreased activity of ADRA1A protein16545797
C057416KT 5720KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
C108255levormeloxifenelevormeloxifene results in decreased expression of ADRA1A mRNA20201831
D008090LisurideLisuride binds to and results in decreased activity of ADRA1A protein16545797
D008090LisurideLisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D008719MethiothepinMethiothepin binds to and results in decreased activity of ADRA1A protein16545797
D008784MethysergideMethysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D013948MoxisylyteMoxisylyte results in decreased activity of ADRA1A protein10699651
D009151Mustard GasMustard Gas results in increased expression of ADRA1A mRNA15674844
D015544Inositol 1,4,5-Trisphosphate"ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate"9570190
D015544Inositol 1,4,5-Trisphosphate"[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
D015544Inositol 1,4,5-Trisphosphate"Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
D015544Inositol 1,4,5-Trisphosphate"Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADRA1A mRNA"25554681
D009278NaphazolineADRA1A protein affects the susceptibility to Naphazoline10381812
D009285NaphthoquinonesNaphthoquinones results in increased expression of ADRA1A mRNA23811387
C054074niguldipineniguldipine binds to ADRA1A protein8183249
D009638NorepinephrineNorepinephrine binds to ADRA1A protein8183249
D009638NorepinephrineNorepinephrine binds to and results in increased activity of ADRA1A protein20030735
D009638Norepinephrine[Norepinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium20030735
D009638NorepinephrineNorepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D009638Norepinephrine5-methylurapidil inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D009638NorepinephrineADRA1A protein affects the susceptibility to Norepinephrine12417256
D009638NorepinephrineBMY 7378 inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D009638Norepinephrine[chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D009638Norepinephrinechlorethylclonidine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D009638NorepinephrineNorepinephrine affects the expression of ADRA1A protein12417256
D009638NorepinephrineNorepinephrine results in increased activity of ADRA1A protein10416824
D009638NorepinephrinePhenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D009638NorepinephrineSpiperone inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D010100OxygenOxygen deficiency results in increased expression of ADRA1A mRNA18084315
D010109OxymetazolineOxymetazoline binds to ADRA1A protein21544540
D010109OxymetazolineOxymetazoline binds to and results in increased activity of ADRA1A protein20030735
D010109Oxymetazoline[Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium20030735
D010109OxymetazolineOxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D010109OxymetazolineOxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]8196478
D010109OxymetazolineOxymetazoline binds to and results in increased activity of ADRA1A protein15872040
D010269ParaquatParaquat results in decreased expression of ADRA1A mRNA17077588
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ADRA1A mRNA27153767
C029261phenethylaminephenethylamine binds to and results in decreased activity of ADRA1A protein20217639
D010643Phenoxybenzamine[chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D010643PhenoxybenzaminePhenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D010646PhentolaminePhentolamine binds to ADRA1A protein15306222|2154454
D010646PhentolaminePhentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D010646PhentolaminePhentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]15306222
D010646PhentolaminePhentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]15306222
D010646PhentolaminePhentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D010646PhentolaminePhentolamine binds to and results in decreased activity of ADRA1A protein16822496
D010656PhenylephrinePhenylephrine binds to and results in increased activity of ADRA1A protein19371927
D010656Phenylephrinesilodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]19371927
D010656Phenylephrine5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]16498073
D010656PhenylephrineADRA1A protein affects the susceptibility to Phenylephrine18257748
D010656Phenylephrinecarvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]15306222
D010656Phenylephrinecarvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]15306222
D010656Phenylephrinecarvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D010656Phenylephrine[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]19419905
D010656Phenylephrine[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine11709419
D010656PhenylephrineKT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D010656PhenylephrinePhentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]15306222
D010656PhenylephrinePhentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]15306222
D010656PhenylephrinePhentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]15306222
D010656PhenylephrinePhenylephrine binds to ADRA1A protein8183249
D010656PhenylephrinePhenylephrine binds to and results in increased activity of ADRA1A protein19419905|2021763
D010656Phenylephrine"[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate"19419905
D010656Phenylephrine[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium19419905
D010656Phenylephrine[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein15306222
D010656Phenylephrine[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein15306222
D010656PhenylephrinePhenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]11709419
D010656PhenylephrinePhenylephrine results in increased activity of ADRA1A protein15306222|1536563
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium15365637
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium15306222|1649807
D010656PhenylephrinePrazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D010656PhenylephrineRo 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D010656Phenylephrine5-methylurapidil inhibits the reaction [ADRA1A protein results in increased susceptibility to Phenylephrine]18604236
D010656PhenylephrineADRA1A protein results in increased susceptibility to Phenylephrine18604236
D010656PhenylephrinePhenylephrine results in increased expression of ADRA1A mRNA17122163
D010656Phenylephrine8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D010656PhenylephrineADRA1A protein results in increased susceptibility to Phenylephrine19566752
D010656PhenylephrineCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]12935885
D010656PhenylephrineCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D010656PhenylephrineCalcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]12935885
D010656PhenylephrineEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]12935885
D010656PhenylephrineEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]12935885
D010656PhenylephrineEthanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]12935885
D010656PhenylephrineGR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D010656PhenylephrineGranisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D010656PhenylephrineLisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D010656PhenylephrineMethysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]16545797
D010656PhenylephrinePhenylephrine affects the activity of ADRA1A protein19133277
D010656Phenylephrine[Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium19133277
D010656PhenylephrinePhenylephrine binds to and results in increased activity of ADRA1A protein15550506|1567241
D010656Phenylephrine[Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium15672411
D010656PhenylephrinePhenylephrine results in increased activity of ADRA1A protein12935885|1560358
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein12935885
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein12935885
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein12935885
D010656Phenylephrine[Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose15550506
D010656Phenylephrinehydroxymaprotilin promotes the reaction [Phenylephrine binds to ADRA1A protein]2158798
D010656PhenylephrinePhenylephrine binds to ADRA1A protein2158798
D010665PhenylpropanolaminePhenylpropanolamine binds to and results in decreased activity of ADRA1A protein20217639
D010716PhosphatidylinositolsADRA1A protein results in increased hydrolysis of Phosphatidylinositols11195782
C006253pirinixic acidpirinixic acid results in increased expression of ADRA1A mRNA18301758|2081375
D059808PolyphenolsPolyphenols results in decreased expression of ADRA1A mRNA16293270
D011188Potassium[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]19419905
D011188PotassiumKT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D011188Potassium[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium19419905
D011188Potassium[Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium15365637
D011188PotassiumPrazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D011188PotassiumRo 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D011188Potassium[Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium19133277
D011224PrazosinPrazosin binds to ADRA1A protein9294627
D011224Prazosin1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]11937776
D011224PrazosinADRA1A protein binds to Prazosin20030735
D011224Prazosinalfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]8196478
D011224PrazosinEpinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D011224PrazosinKetanserin inhibits the reaction [Prazosin binds to ADRA1A protein]11937776
D011224PrazosinNorepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D011224PrazosinOxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D011224PrazosinOxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]8196478
D011224PrazosinPrazosin binds to ADRA1A protein7536677|8183249|
D011224PrazosinPrazosin binds to and results in decreased activity of ADRA1A protein15627480
D011224PrazosinPrazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
D011224Prazosinsarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]11937776
D011224Prazosinxylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D011224PrazosinPrazosin binds to and results in decreased activity of ADRA1A protein12560108
D011224PrazosinPrazosin results in decreased activity of ADRA1A protein6310690
D011224PrazosinPrazosin binds to ADRA1A protein7536677
D011224PrazosinPrazosin binds to and affects the activity of ADRA1A protein9639061
D011224PrazosinPrazosin binds to and results in decreased activity of ADRA1A protein15550506|1595134
D011224PrazosinPrazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]15550506
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
D011224PrazosinPrazosin results in increased expression of ADRA1A mRNA11693201
D011224PrazosinPrazosin results in increased expression of ADRA1A protein11934817
D011224PrazosinPrazosin binds to ADRA1A protein2158798
D011224PrazosinPrazosin binds to and results in decreased activity of ADRA1A protein16822496|7753402
D019269Phosphatidylinositol 4,5-Diphosphate"[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate"19419905
D011802QuinidineQuinidine binds to ADRA1A protein9570190
D011802Quinidine"[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
D011802Quinidine"Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of ADRA1A mRNA20201831
C085989Ro 32-0432Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]15365637
C120711RS 100329RS 100329 binds to and results in decreased activity of ADRA1A protein19566752
C064294sarpogrelatesarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]11937776
C066304sertindolesertindole binds to and results in decreased activity of ADRA1A protein11596272
C066304sertindolesertindole inhibits the reaction [BE 2254 binds to ADRA1A protein]11596272
C095285silodosinsilodosin binds to and results in decreased activity of ADRA1A protein19371927
C095285silodosinsilodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]19371927
C095285silodosinsilodosin binds to ADRA1A protein15306222
C095285silodosinsilodosin binds to and results in decreased activity of ADRA1A protein20126606
D013134SpiperoneSpiperone inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]10416824
C030655St 587St 587 binds to and results in increased activity of ADRA1A protein1685570
D013311StreptozocinStreptozocin results in increased expression of ADRA1A mRNA19133277
D013311StreptozocinStreptozocin results in increased expression of ADRA1A protein19133277
D013578SynephrineSynephrine binds to and results in increased activity of ADRA1A protein20217639
C088482tamsulosintamsulosin binds to ADRA1A protein9294627
C088482tamsulosintamsulosin binds to ADRA1A protein21544540|7536677
C088482tamsulosintamsulosin binds to ADRA1A protein7536677
C088482tamsulosintamsulosin binds to and results in decreased activity of ADRA1A protein20126606|7913781
C041226TerazosinTerazosin binds to ADRA1A protein9294627
C041226TerazosinTerazosin binds to ADRA1A protein21544540|7536677
C041226TerazosinTerazosin binds to ADRA1A protein7536677
C041226TerazosinTerazosin binds to and results in decreased activity of ADRA1A protein20126606|7913781
D013739TestosteroneTestosterone results in increased expression of ADRA1A protein18157169
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADRA1A mRNA20106945|2615948
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ADRA1A mRNA25975270
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ADRA1A mRNA7900855
D014147TramadolTramadol results in increased expression of ADRA1A protein15464068
C057693troglitazonetroglitazone results in increased expression of ADRA1A mRNA28934090
C057693troglitazonetroglitazone results in increased expression of ADRA1A mRNA28973697
C561310UNC 0638UNC 0638 results in decreased activity of ADRA1A protein21743462
C015568urapidilurapidil binds to and results in decreased activity of ADRA1A protein9829161
D014700Verapamil"[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
D014700VerapamilVerapamil binds to ADRA1A protein9570190
D014700Verapamil"Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"9570190
C009695xylometazolinexylometazoline binds to ADRA1A protein20030735
C009695xylometazolinexylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]20030735
D015032ZincZinc deficiency results in increased expression of ADRA1A mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004935adrenergic receptor activity-IBA21873635  
GO:0004937alpha1-adrenergic receptor activity-IBA21873635  
GO:0004937alpha1-adrenergic receptor activity-ISS-  
GO:0004937alpha1-adrenergic receptor activity-NAS9490024  
GO:0004937alpha1-adrenergic receptor activity-TAS7737411  
GO:0005515protein binding-IPI24567387  
GO:0046982protein heterodimerization activity-IDA22120526  
GO ID GO Term Qualifier Evidence PubMed
GO:0001985negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure-IEA-  
GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure-IBA21873635  
GO:0001996positive regulation of heart rate by epinephrine-norepinephrine-IEA-  
GO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrine-IEA-  
GO:0003084positive regulation of systemic arterial blood pressure-IEA-  
GO:0006915apoptotic process-TAS10671514  
GO:0006939smooth muscle contraction-TAS8183249  
GO:0007165signal transduction-TAS8396931  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007202activation of phospholipase C activity-ISS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007267cell-cell signaling-TAS8396931  
GO:0007512adult heart development-IEA-  
GO:0007568aging-ISS-  
GO:0008285negative regulation of cell proliferation-TAS10860850  
GO:0009725response to hormone-ISS-  
GO:0010507negative regulation of autophagy-IEA-  
GO:0010613positive regulation of cardiac muscle hypertrophy-IEA-  
GO:0032230positive regulation of synaptic transmission, GABAergic-ISS-  
GO:0035024negative regulation of Rho protein signal transduction-ISS-  
GO:0035556intracellular signal transduction-TAS10671514  
GO:0042493response to drug-ISS-  
GO:0043410positive regulation of MAPK cascade-IDA22120526  
GO:0045760positive regulation of action potential-ISS-  
GO:0045907positive regulation of vasoconstriction-IBA21873635  
GO:0045907positive regulation of vasoconstriction-ISS-  
GO:0045987positive regulation of smooth muscle contraction-IBA21873635  
GO:0060073micturition-IEA-  
GO:0060402calcium ion transport into cytosol-ISS-  
GO:0060452positive regulation of cardiac muscle contraction-ISS-  
GO:0061049cell growth involved in cardiac muscle cell development-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0071880adenylate cyclase-activating adrenergic receptor signaling pathway-IBA21873635  
GO:0090037positive regulation of protein kinase C signaling-ISS-  
GO:0097195pilomotor reflex-IEA-  
GO:1903997positive regulation of non-membrane spanning protein tyrosine kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA22120526  
GO:0005737cytoplasm-IDA24567387  
GO:0005886plasma membrane-IDA24567387  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8396931  
GO:0005901caveola-IEA-  
GO:0030018Z disc-IEA-  
GO:0030315T-tubule-IEA-  
GO:0031965nuclear membrane-IDA22120526  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390696AdrenoceptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26227246Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. (2015)Levran OPharmacogenomics
23849431Pharmacogenetic randomized trial for cocaine abuse: disulfiram and alpha1A-adrenoceptor gene variation. (2013 Nov)Shorter DEur Neuropsychopharmacol