Gene: CTBP2

1488
-
C-terminal binding protein 2
protein-coding
10q26.13
Ensembl:ENSG00000175029 MIM:602619 Vega:OTTHUMG00000019224 UniprotKB:P56545
NC_000010.11
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.974e-1 (AD)  1.924e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12761801chr10:125084412 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs11595908chr10:125018107 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12781214chr10:125013480 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4962416chr10:125008303 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAPOLA0.871
CRK0.849
XPO10.848
RAB100.846
STAT5B0.845
PPP1CC0.843
G3BP10.836
CANX0.833
POLDIP30.829
ZMPSTE240.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.72
OR4F29-0.69
TCL1A-0.155
LCE3A-0.149
NCBP2L-0.146
OR6C74-0.146
RNASE8-0.14
PATE3-0.137
NANOGNB-0.129
SPRR2B-0.127

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CTBP2 mRNA"19114083
C0146322-keto-4-methylthiobutyric acid2-keto-4-methylthiobutyric acid results in decreased expression of CTBP2 protein28414304
C0146322-keto-4-methylthiobutyric acid2-keto-4-methylthiobutyric acid results in decreased expression of CTBP2 protein28414304
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTBP2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CTBP2 mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CTBP2 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTBP2 mRNA16483693
D001151ArsenicArsenic affects the methylation of CTBP2 gene25304211
C006632arsenic trioxideCTBP2 protein results in decreased susceptibility to arsenic trioxide20707922
D001194AsbestosAsbestos affects the expression of CTBP2 mRNA17297452
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CTBP2 mRNA20064835|2187194
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of CTBP2 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CTBP2 mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CTBP2 mRNA"26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CTBP2 mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the expression of CTBP2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CTBP2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CTBP2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTBP2 mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of CTBP2 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CTBP2 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CTBP2 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTBP2 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of CTBP2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of CTBP2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of CTBP2 mRNA20106945
D016572CyclosporineCyclosporine results in increased methylation of CTBP2 promoter27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTBP2 mRNA28628672
D003994BucladesineBucladesine affects the localization of CTBP2 protein18184656
D003994BucladesineBucladesine promotes the reaction [CTBP1 protein binds to CTBP2 protein]18184656
D004008DiclofenacDiclofenac affects the expression of CTBP2 mRNA24752500
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of CTBP2 mRNA17490981
D004041Dietary FatsDietary Fats results in increased expression of CTBP2 mRNA18042831
C118739entinostatentinostat results in increased expression of CTBP2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTBP2 mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CTBP2 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CTBP2 mRNA17606305
D005472FluorouracilCTBP2 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in decreased expression of CTBP2 mRNA16391804
D005485FlutamideFlutamide results in decreased expression of CTBP2 mRNA21126777
D005485FlutamideFlutamide results in increased expression of CTBP2 mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTBP2 mRNA20938992
C039281furanfuran results in increased expression of CTBP2 mRNA27387713
C039281furanfuran results in increased methylation of CTBP2 gene22079235
D019833GenisteinGenistein results in increased expression of CTBP2 mRNA15256057
D017313FenretinideFenretinide results in decreased expression of CTBP2 mRNA16467112
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTBP2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CTBP2 mRNA25613284
C051890irinotecanCTBP2 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in decreased expression of CTBP2 mRNA16391804
C051890irinotecanirinotecan analog results in decreased expression of CTBP2 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CTBP2 mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CTBP2 mRNA"24972896
D008694MethamphetamineMethamphetamine results in decreased methylation of CTBP2 promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of CTBP2 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTBP2 mRNA20938992
C500085muraglitazarmuraglitazar results in increased expression of CTBP2 mRNA21515302
D009151Mustard GasMustard Gas affects the expression of CTBP2 mRNA15651846
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of CTBP2 mRNA16467112
D009532NickelNickel results in decreased expression of CTBP2 mRNA23195993
D000073878Palm OilPalm Oil results in increased expression of CTBP2 mRNA18042831
D010667Phenylpyruvic AcidsPhenylpyruvic Acids results in decreased expression of CTBP2 protein28414304
D010667Phenylpyruvic AcidsPhenylpyruvic Acids results in decreased expression of CTBP2 protein28414304
D019289Pyruvic AcidPyruvic Acid affects the localization of CTBP2 protein18184656
D019289Pyruvic AcidPyruvic Acid inhibits the reaction [CTBP1 protein binds to CTBP2 protein]18184656
D019289Pyruvic AcidPyruvic Acid promotes the reaction [CTBP2 protein binds to CYP17A1 promoter]18184656
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CTBP2 mRNA19244175
D012643SeleniumSelenium results in decreased expression of CTBP2 mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of CTBP2 gene28589171
C501413tesaglitazartesaglitazar results in increased expression of CTBP2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CTBP2 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CTBP2 mRNA15034205|1946511
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CTBP2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CTBP2 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CTBP2 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of CTBP2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of CTBP2 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of CTBP2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CTBP2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of CTBP2 mRNA21515302
D014520UrethaneUrethane results in decreased expression of CTBP2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CTBP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CTBP2 gene28853863
D014635Valproic AcidValproic Acid results in increased expression of CTBP2 mRNA24935251|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CTBP2 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CTBP2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of CTBP2 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of CTBP2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  16702210  19486893  21516116  21903422  21988832  
25416956  25728771  25910212  26871637  27705803  
GO:0019901protein kinase binding-IPI23393140  
GO:0044877protein-containing complex binding-IPI23393140  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0008285negative regulation of cell proliferation-TAS9479502  
GO:0019079viral genome replication-TAS9479502  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP23775127  
GO:0048386positive regulation of retinoic acid receptor signaling pathway-IMP23775127  
GO:0050872white fat cell differentiation-ISS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16702210  
GO:0005634nucleus-ISS-  
GO:0017053transcriptional repressor complex-ISS-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-4641265Repression of WNT target genesTAS
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5339700TCF7L2 mutants don't bind CTBPTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal