Gene: NEK10

152110
-
NIMA related kinase 10
protein-coding
3p24.1
Ensembl:ENSG00000163491 Vega:OTTHUMG00000130571 UniprotKB:Q6ZWH5
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
6.085e-1 (AD)  2.256e-1 (ND)   (Frontal_Cortex)
8.615e-1 (AD)  8.268e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1522153chr3:27129286 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH80.899
CAMK40.895
NDST30.888
CACNA1D0.887
RPGRIP1L0.886
GULP10.882
DGKI0.881
NBEA0.88
MTMR70.88
SCN8A0.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.619
RAB13-0.61
MYL3-0.584
CSAG1-0.577
EMP3-0.556
TSPO-0.556
FLT3LG-0.55
HEBP2-0.549
PXDC1-0.545
HEY2-0.545

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NEK10 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NEK10 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEK10 mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of NEK10 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of NEK10 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of NEK10 mRNA19549813
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of NEK10 mRNA21334430
C005556propionaldehydepropionaldehyde results in increased expression of NEK10 mRNA26079696
D014635Valproic AcidValproic Acid results in decreased methylation of NEK10 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA20956560  
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA20956560  
GO:0031954positive regulation of protein autophosphorylation-IDA20956560  
GO:0043406positive regulation of MAP kinase activity-IMP20956560  
GO:0070372regulation of ERK1 and ERK2 cascade-IMP20956560  
GO:1902749regulation of cell cycle G2/M phase transition-IMP20956560  
GO ID GO Term Qualifier Evidence PubMed
GO:1902911protein kinase complex-IDA20956560  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal