Gene: ZNF827

152485
-
zinc finger protein 827
protein-coding
4q31.21-q31.22
Ensembl:ENSG00000151612 MIM:617962 Vega:OTTHUMG00000161362 UniprotKB:Q17R98
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.538e-1 (AD)  5.276e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1027841chr4:145847922 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LONP20.912
RPRD20.91
ASTN10.907
RIC30.904
CLASP10.902
ANKRD260.901
CELF20.899
RALGAPB0.899
ZNF2360.898
SIPA1L10.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.51
OR4F29-0.466
TFPI2-0.408
CSAG1-0.388
PGF-0.381
SPINK8-0.367
RAB13-0.357
HEY2-0.343
KLRB1-0.343
GNG11-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ZNF827 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF827 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF827 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ZNF827 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZNF827 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZNF827 mRNA24449571
D001151ArsenicArsenic affects the methylation of ZNF827 gene25304211
D001280AtrazineAtrazine results in decreased expression of ZNF827 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of ZNF827 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZNF827 mRNA26079696
C014347decitabinedecitabine affects the expression of ZNF827 mRNA23300844
D002945CisplatinCisplatin affects the expression of ZNF827 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF827 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ZNF827 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF827 mRNA22079256
D005557FormaldehydeFormaldehyde results in increased expression of ZNF827 mRNA23649840
D017313FenretinideFenretinide results in increased expression of ZNF827 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZNF827 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF827 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of ZNF827 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZNF827 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZNF827 mRNA24796395|2530787
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZNF827 mRNA]26733615
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ZNF827 mRNA22839698
D008727MethotrexateMethotrexate results in increased expression of ZNF827 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ZNF827 mRNA26011545
D009532NickelNickel results in decreased expression of ZNF827 mRNA24768652|2558310
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZNF827 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of ZNF827 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZNF827 mRNA]26733615
C046012pentanalpentanal results in decreased expression of ZNF827 mRNA26079696
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF827 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ZNF827 mRNA22079256|2271453
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ZNF827 mRNA25895662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZNF827 mRNA25613284
D014212TretinoinTretinoin results in increased expression of ZNF827 mRNA21934132
D014520UrethaneUrethane results in decreased expression of ZNF827 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF827 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZNF827 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF827 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of ZNF827 mRNA22714537
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ZNF827 mRNA22839698
C088658zoledronic acidzoledronic acid results in increased expression of ZNF827 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25150861  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0010468regulation of gene expression-IBA21873635  
GO:0016569covalent chromatin modification-IBA21873635  
GO:0031060regulation of histone methylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleusCOLOCALIZES_WITHIBA21873635  
GO:0005634nucleus-IEA-  
GO:0035097histone methyltransferase complexCOLOCALIZES_WITHIBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal