Gene: DAB2IP

153090
AF9Q34|AIP-1|AIP1|DIP1/2
DAB2 interacting protein
protein-coding
9q33.2
Ensembl:ENSG00000136848 MIM:609205 Vega:OTTHUMG00000020595 UniprotKB:Q5VWQ8
NC_000009.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.095e-1 (AD)  2.926e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1757321chr9:121569480 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NACC10.917
PRRC2A0.909
BAP10.906
TNPO20.906
TRAF70.905
RAPGEF10.904
PPP6R10.901
DLGAP40.9
SCMH10.898
GNA110.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.739
OR4F29-0.698
ANXA13-0.372
CTNNA3-0.356
SH2D1A-0.347
DTHD1-0.332
SGMS2-0.327
FXYD4-0.317
C5orf64-0.314
TMEM139-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DAB2IP mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DAB2IP mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DAB2IP gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DAB2IP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DAB2IP mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of DAB2IP mRNA22521957
D001280AtrazineAtrazine results in decreased expression of DAB2IP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DAB2IP mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DAB2IP mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of DAB2IP mRNA27685785
C006780bisphenol Abisphenol A affects the expression of DAB2IP mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DAB2IP mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DAB2IP mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of DAB2IP mRNA19320972
D003042CocaineCocaine results in decreased expression of DAB2IP mRNA17898221
D019327Copper SulfateCopper Sulfate results in decreased expression of DAB2IP mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of DAB2IP mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of DAB2IP mRNA27392435
D002945CisplatinCisplatin results in increased expression of DAB2IP mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of DAB2IP mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of DAB2IP mRNA16002434
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DAB2IP mRNA18936297
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of DAB2IP mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of DAB2IP mRNA16807920
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DAB2IP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DAB2IP mRNA"25554681
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of DAB2IP mRNA25626140
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DAB2IP mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased methylation of DAB2IP gene25199682
D013629TamoxifenTamoxifen results in increased expression of DAB2IP mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DAB2IP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DAB2IP mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DAB2IP mRNA21215274
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DAB2IP mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DAB2IP mRNA17292431|1796380
C025643vinclozolinvinclozolin affects the expression of DAB2IP mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005123death receptor binding-IPI15310755  
GO:0005515protein binding-IPI12813029  17389591  19903888  20080667  
GO:0017124SH3 domain binding-IDA19033661  19903888  
GO:0019900kinase binding-IPI17389591  
GO:0019901protein kinase binding-IDA18281285  
GO:0019901protein kinase binding-IPI20080667  
GO:0031434mitogen-activated protein kinase kinase binding-IPI17389591  
GO:0031435mitogen-activated protein kinase kinase kinase binding-IPI12813029  
GO:0032266phosphatidylinositol-3-phosphate binding-IDA19948740  
GO:0035591signaling adaptor activity-IDA20080667  
GO:0035662Toll-like receptor 4 bindingNOTIDA19948740  
GO:0036312phosphatidylinositol 3-kinase regulatory subunit binding-IDA19903888  
GO:0042802identical protein binding-IPI12813029  
GO:0042803protein homodimerization activity-IPI12813029  
GO:0043184vascular endothelial growth factor receptor 2 binding-IPI19033661  
GO:0043548phosphatidylinositol 3-kinase binding-IDA19033661  
GO:0044877protein-containing complex binding-IDA19903888  
GO:0045296cadherin binding-HDA25468996  
GO:0051721protein phosphatase 2A binding-IDA20080667  
GO:0070273phosphatidylinositol-4-phosphate binding-IDA19948740  
GO:007188914-3-3 protein binding-IDA17389591  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15310755  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP20154697  
GO:0000165MAPK cascade-TAS-  
GO:0000185activation of MAPKKK activity-IDA19903888  
GO:0001525angiogenesis-IEA-  
GO:0001933negative regulation of protein phosphorylation-IMP20080667  
GO:0001933negative regulation of protein phosphorylation-ISS-  
GO:0006954inflammatory response-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007252I-kappaB phosphorylation-ISS-  
GO:0007257activation of JUN kinase activity-IDA12813029  
GO:0008285negative regulation of cell proliferation-IDA19903888  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IMP19903888  
GO:0010596negative regulation of endothelial cell migration-IMP19033661  
GO:0010633negative regulation of epithelial cell migration-IMP20080667  
GO:0010633negative regulation of epithelial cell migration-TAS20080667  
GO:0010719negative regulation of epithelial to mesenchymal transition-IDA20154697  
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP20080667  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling-IDA19903888  
GO:0016525negative regulation of angiogenesis-IDA19033661  
GO:0021814cell motility involved in cerebral cortex radial glia guided migration-ISS-  
GO:0021819layer formation in cerebral cortex-ISS-  
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-IMP19033661  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IMP20154697  
GO:0034144negative regulation of toll-like receptor 4 signaling pathway-IDA19948740  
GO:0034260negative regulation of GTPase activity-IMP20154697  
GO:0034260negative regulation of GTPase activity-ISS-  
GO:0034620cellular response to unfolded protein-TAS22013210  
GO:0035148tube formation-IMP19033661  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IDA19033661  
GO:0035924cellular response to vascular endothelial growth factor stimulus-ISS-  
GO:0036324vascular endothelial growth factor receptor-2 signaling pathway-ISS-  
GO:0038026reelin-mediated signaling pathway-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway-ISS11812785  
GO:0043065positive regulation of apoptotic process-IDA17389591  19903888  
GO:0043087regulation of GTPase activity-ISS-  
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling-ISS-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IDA15310755  17389591  
GO:0043254regulation of protein complex assembly-IDA19948740  
GO:0043407negative regulation of MAP kinase activity-IDA12813029  
GO:0043407negative regulation of MAP kinase activity-IMP20154697  
GO:0043410positive regulation of MAPK cascade-IDA19903888  
GO:0043497regulation of protein heterodimerization activity-IDA18281285  
GO:0043507positive regulation of JUN kinase activity-IDA15310755  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0043553negative regulation of phosphatidylinositol 3-kinase activity-IDA19903888  
GO:0044257cellular protein catabolic process-IDA17389591  
GO:0045087innate immune response-IEA-  
GO:0045732positive regulation of protein catabolic process-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IMP20080667  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15310755  17389591  
GO:0046330positive regulation of JNK cascade-IDA17389591  19903888  
GO:0046580negative regulation of Ras protein signal transduction-IC20154697  
GO:0048147negative regulation of fibroblast proliferation-ISS-  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0050680negative regulation of epithelial cell proliferation-IMP20154697  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-ISS18281285  
GO:0070317negative regulation of G0 to G1 transition-IDA19903888  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IDA19903888  
GO:0071158positive regulation of cell cycle arrest-IDA19903888  
GO:0071222cellular response to lipopolysaccharide-IDA19948740  
GO:0071347cellular response to interleukin-1-IDA19948740  
GO:0071356cellular response to tumor necrosis factor-IDA12813029  15310755  17389591  
GO:0071364cellular response to epidermal growth factor stimulus-ISS11812785  
GO:0071901negative regulation of protein serine/threonine kinase activity-IDA19903888  
GO:0071901negative regulation of protein serine/threonine kinase activity-IMP20154697  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA19903888  
GO:0071902positive regulation of protein serine/threonine kinase activity-IMP20080667  
GO:0072577endothelial cell apoptotic process-TAS19903888  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP20080667  
GO:0090090negative regulation of canonical Wnt signaling pathway-ISS-  
GO:0090129positive regulation of synapse maturation-ISS-  
GO:1900006positive regulation of dendrite development-ISS-  
GO:1900744regulation of p38MAPK cascade-ISS-  
GO:1900747negative regulation of vascular endothelial growth factor signaling pathway-ISS-  
GO:1901800positive regulation of proteasomal protein catabolic process-IMP20080667  
GO:1903363negative regulation of cellular protein catabolic process-IDA19903888  
GO:1903896positive regulation of IRE1-mediated unfolded protein response-TAS22013210  
GO:2001224positive regulation of neuron migration-ISS-  
GO:2001235positive regulation of apoptotic signaling pathway-IDA19903888  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15310755  19948740  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA15310755  19948740  
GO:0030139endocytic vesicle-IDA19948740  
GO:0030424axon-ISS-  
GO:0030425dendrite-IEA-  
GO:0032809neuronal cell body membrane-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0044300cerebellar mossy fiber-ISS-  
GO:0044301climbing fiber-ISS-  
GO:1990032parallel fiber-ISS-  
GO:1990597AIP1-IRE1 complex-IDA18281285  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20622881Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. (2010 Aug)Gretarsdottir SNat Genet
28167353Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)Shahid SUAtherosclerosis