Gene: SAMD3

154075
-
sterile alpha motif domain containing 3
protein-coding
6q23.1
Ensembl:ENSG00000164483 Vega:OTTHUMG00000015556 UniprotKB:Q8N6K7
NC_000006.12
SNP Mapped
1   ANCO-SNPs
OD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.011e-1 (AD)  8.007e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10223341chr6:130174738 (GRCh38.p7)G>Topioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02227813chr6:130524018SAMD31.070e-10Maternal smoking in pregnancy27040690
cg02227813chr6:130524018SAMD31.900e-12Maternal smoking in pregnancy27040690
cg02227813chr6:130524018SAMD38.370e-17Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SKAP10.549
CD163L10.544
LGI20.541
IL1RAP0.527
GALR10.521
CTHRC10.515
GZMA0.513
CITED10.508
GCNT10.507
AIRE0.505

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC39A12-0.445
KLF15-0.426
NWD1-0.419
LRP4-0.416
CABLES1-0.415
PLIN4-0.391
ACSS3-0.381
SLC14A1-0.38
SLCO1C1-0.379
ZNRF3-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SAMD3 mRNA24449571
D001151ArsenicArsenic affects the methylation of SAMD3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SAMD3 mRNA22316170
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SAMD3 mRNA22079614
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SAMD3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SAMD3 mRNA23086925
D009532NickelNickel results in increased expression of SAMD3 mRNA25583101
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SAMD3 mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SAMD3 mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of SAMD3 mRNA26705709
D014635Valproic AcidValproic Acid affects the expression of SAMD3 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SAMD3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23455924  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal