Gene: NKAIN2

154215
FAM77B|NKAIP2|TCBA|TCBA1
sodium/potassium transporting ATPase interacting 2
protein-coding
6q22.31
Ensembl:ENSG00000188580 MIM:609758 Vega:OTTHUMG00000015500 UniprotKB:Q5VXU1
NG_021365.1
PubMed|SNP Mapped
2   ANCO-SNPs
OD|ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.635e-1 (AD)  5.910e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs192590503chr6:124215869 (GRCh38.p7)G>Aopioid dependenceSNV(Single Nucleotide Variation)
rs594664chr6:124121141 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGTPBP10.902
LDLRAD40.896
NIPAL30.894
NIPA10.894
TMEFF10.887
HBS1L0.886
KIAA1324L0.884
SH3GL30.883
TMEFF20.882
GNAI10.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.449
INHBB-0.436
EVC2-0.432
RNF135-0.429
SYPL2-0.424
SIX5-0.423
GJB2-0.421
RREB1-0.417
EYA2-0.406
OR4F5-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NKAIN2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NKAIN2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NKAIN2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NKAIN2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NKAIN2 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NKAIN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NKAIN2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NKAIN2 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NKAIN2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NKAIN2 mRNA21298039
D001151ArsenicArsenic affects the methylation of NKAIN2 gene25304211
D001280AtrazineAtrazine results in decreased expression of NKAIN2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NKAIN2 mRNA20106945|2187194
D016572CyclosporineCyclosporine results in increased expression of NKAIN2 mRNA20106945
C492448ICG 001ICG 001 results in increased expression of NKAIN2 mRNA26191083
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NKAIN2 mRNA24810058
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NKAIN2 mRNA"25510870
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NKAIN2 mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of NKAIN2 mRNA24675092
D014212TretinoinTretinoin results in increased expression of NKAIN2 mRNA21934132
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NKAIN2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NKAIN2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NKAIN2 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of NKAIN2 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in decreased expression of NKAIN2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NKAIN2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0002028regulation of sodium ion transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21445666Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. (2011 Sep)Wang KSJ Neural Transm (Vienna)