Gene: PRAG1

157285
NACK|PEAK2|PRAGMIN|SGK223
PEAK1 related, kinase-activating pseudokinase 1
protein-coding
8p23.1
Ensembl:ENSG00000275342 MIM:617344 Vega:OTTHUMG00000163709 UniprotKB:Q86YV5
NC_000008.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.826e-1 (AD)  9.738e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2921010chr8:8372845 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PRAG1 mRNA"22698814
C0127962-butenal2-butenal results in decreased expression of PRAG1 mRNA20471460
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of PRAG1 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of PRAG1 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PRAG1 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of PRAG1 mRNA28959563
D001151ArsenicArsenic affects the methylation of PRAG1 gene25304211
D001379AzathioprineAzathioprine results in increased expression of PRAG1 mRNA22623647
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of PRAG1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRAG1 mRNA21632981|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PRAG1 gene25435355
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of PRAG1 mRNA]24758408
D004958EstradiolEstradiol affects the expression of PRAG1 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PRAG1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of PRAG1 mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of PRAG1 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of PRAG1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PRAG1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PRAG1 mRNA17484886
D019327Copper SulfateCopper Sulfate results in increased expression of PRAG1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PRAG1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of PRAG1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of PRAG1 mRNA23946490
D003907DexamethasoneValproic Acid inhibits the reaction [Dexamethasone results in increased expression of PRAG1 mRNA]23946490
D002945CisplatinCisplatin results in increased expression of PRAG1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of PRAG1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PRAG1 mRNA25016146
D005557FormaldehydeFormaldehyde results in decreased expression of PRAG1 mRNA20655997
C039281furanfuran results in increased expression of PRAG1 mRNA27387713
C004312glycidolglycidol results in increased expression of PRAG1 mRNA24915197
D017313FenretinideFenretinide results in increased expression of PRAG1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of PRAG1 mRNA26191083
C045463leflunomideleflunomide results in increased expression of PRAG1 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PRAG1 mRNA"20188158
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PRAG1 mRNA26272509
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of PRAG1 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRAG1 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PRAG1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PRAG1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PRAG1 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of PRAG1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of PRAG1 mRNA24780913
D011794QuercetinQuercetin results in increased expression of PRAG1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of PRAG1 mRNA23221170
D012834SilverSilver results in increased expression of PRAG1 mRNA28959546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRAG1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRAG1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of PRAG1 protein23298284
D013853ThioacetamideThioacetamide results in increased expression of PRAG1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRAG1 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PRAG1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PRAG1 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRAG1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PRAG1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PRAG1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PRAG1 gene29154799
D014635Valproic AcidValproic Acid inhibits the reaction [Dexamethasone results in increased expression of PRAG1 mRNA]23946490
D014638VanadatesVanadates results in increased expression of PRAG1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PRAG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IEA-  
GO:0005515protein binding-IPI29079850  
GO:0005524ATP bindingNOTISS-  
GO:0042802identical protein binding-IDA29079850  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0008360regulation of cell shape-ISS-  
GO:0008593regulation of Notch signaling pathway-ISS-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0016477cell migration-IMP29079850  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0035025positive regulation of Rho protein signal transduction-ISS-  
GO:2000145regulation of cell motility-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005925focal adhesion-IDA27116701  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal