Gene: PRUNE2

158471
BMCC1|BNIPXL|C9orf65|KIAA0367
prune homolog 2
protein-coding
9q21.2
Ensembl:ENSG00000106772 MIM:610691 Vega:OTTHUMG00000020047 UniprotKB:Q8WUY3
NC_000009.12
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.227e-1 (AD)  6.042e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7046144chr9:76616633 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCOA70.953
MFSD60.951
SRPK20.945
DNAJC60.943
RAB3GAP10.938
PTPRD0.937
EIF4G30.937
CCSER20.935
LPGAT10.934
AKAP60.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.444
MTRNR2L10-0.433
OR4F29-0.428
MTRNR2L8-0.428
MTRNR2L6-0.427
RAB13-0.424
MTRNR2L9-0.416
RNF135-0.414
MDFI-0.413
MTRNR2L2-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRUNE2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRUNE2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRUNE2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRUNE2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRUNE2 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of PRUNE2 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PRUNE2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PRUNE2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PRUNE2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PRUNE2 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRUNE2 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of PRUNE2 mRNA17404688
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of PRUNE2 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of PRUNE2 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRUNE2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PRUNE2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PRUNE2 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRUNE2 mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of PRUNE2 mRNA25979313
D016572CyclosporineCyclosporine results in increased expression of PRUNE2 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of PRUNE2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRUNE2 mRNA28628672
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PRUNE2 mRNA25380136
C118739entinostatentinostat results in decreased expression of PRUNE2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
D017313FenretinideFenretinide results in decreased expression of PRUNE2 mRNA28973697
D006854HydrocortisoneHydrocortisone results in decreased expression of PRUNE2 mRNA21267416
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRUNE2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRUNE2 mRNA28628672
D007854LeadLead affects the expression of PRUNE2 mRNA28903495
D008558MelphalanMelphalan results in decreased expression of PRUNE2 mRNA22363485
C042720mercuric bromidemercuric bromide results in decreased expression of PRUNE2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of PRUNE2 mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of PRUNE2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRUNE2 mRNA28001369
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of PRUNE2 mRNA19465457
C523799MRK 003PRUNE2 results in increased susceptibility to MRK 00319903844
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of PRUNE2 mRNA25380136
D009532NickelNickel results in decreased expression of PRUNE2 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of PRUNE2 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PRUNE2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PRUNE2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of PRUNE2 mRNA24236059
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of PRUNE2 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased methylation of PRUNE2 gene28495853
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRUNE2 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PRUNE2 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PRUNE2 mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of PRUNE2 mRNA17404688
C009277sodium arsenatesodium arsenate results in decreased expression of PRUNE2 mRNA21795629
C004648testosterone enanthatetestosterone enanthate affects the expression of PRUNE2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRUNE2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRUNE2 mRNA26232522
C009495titanium dioxidetitanium dioxide results in increased expression of PRUNE2 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PRUNE2 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PRUNE2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PRUNE2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of PRUNE2 mRNA16288218
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PRUNE2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of PRUNE2 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PRUNE2 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRUNE2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PRUNE2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of PRUNE2 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRUNE2 gene28495853
C111237vorinostatvorinostat results in decreased expression of PRUNE2 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of PRUNE2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004309exopolyphosphatase activity-IBA21873635  
GO:0016462pyrophosphatase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006798polyphosphate catabolic process-IBA21873635  
GO:0006915apoptotic process-IBA21873635  
GO:0006915apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal