Gene: DACH1

1602
DACH
dachshund family transcription factor 1
protein-coding
13q21.33
Ensembl:ENSG00000276644 MIM:603803 Vega:OTTHUMG00000017063 UniprotKB:Q9UI36
NG_011849.3
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.213e-1 (AD)  9.749e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17088471chr13:71768304 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXP20.873
SEMA3E0.842
CHN20.838
THEMIS0.822
TLL10.822
PCDH11X0.807
OPRK10.807
MCTP20.789
FILIP10.788
KCNK20.783

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MSX1-0.475
WNT7B-0.443
C4orf19-0.437
C1QL2-0.432
OAF-0.424
RLBP1-0.419
MAPKAPK3-0.417
HS3ST3A1-0.409
PLA2G5-0.405
TFAP2C-0.404

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of DACH1 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DACH1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DACH1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DACH1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DACH1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DACH1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DACH1 mRNA25458485
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DACH1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DACH1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of DACH1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of DACH1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of DACH1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of DACH1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DACH1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DACH1 mRNA23735875
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of DACH1 mRNA20660070
D002737ChloropreneChloroprene results in decreased expression of DACH1 mRNA23125180
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DACH1 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of DACH1 mRNA20106945
C042577diallyl trisulfidediallyl trisulfide results in increased expression of DACH1 mRNA27129776
C042577diallyl trisulfideFOXQ1 protein inhibits the reaction [diallyl trisulfide results in increased expression of DACH1 mRNA]27129776
D002945CisplatinCisplatin results in decreased expression of DACH1 mRNA27594783
C118739entinostatentinostat results in decreased expression of DACH1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DACH1 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DACH1 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of DACH1 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DACH1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DACH1 mRNA"25554681
C000621033napabucasinnapabucasin results in decreased expression of DACH1 mRNA25605917
D009532NickelNickel results in decreased expression of DACH1 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in decreased expression of DACH1 mRNA17312168
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DACH1 mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DACH1 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
D010936Plant ExtractsPlant Extracts results in decreased expression of DACH1 mRNA24677778
D011192Potassium DichromatePotassium Dichromate results in increased expression of DACH1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of DACH1 mRNA20660070
D053260SootSoot results in decreased expression of DACH1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DACH1 mRNA24058054
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DACH1 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of DACH1 mRNA23557971
D014212TretinoinTretinoin results in increased expression of DACH1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DACH1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DACH1 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of DACH1 mRNA24935251
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of DACH1 mRNA28666766
D014415TunicamycinTunicamycin results in decreased expression of DACH1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of DACH1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DACH1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of DACH1 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DACH1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001075transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20956529  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI14525983  16189514  20956529  21516116  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001967suckling behavior-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0010944negative regulation of transcription by competitive promoter binding-IMP20956529  
GO:0030336negative regulation of cell migration-IDA20956529  
GO:0033262regulation of nuclear cell cycle DNA replication-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IMP21750150  
GO:0046545development of primary female sexual characteristics-IEA-  
GO:0048147negative regulation of fibroblast proliferation-IEA-  
GO:0051123RNA polymerase II transcriptional preinitiation complex assembly-IEA-  
GO:0060244negative regulation of cell proliferation involved in contact inhibition-IEA-  
GO:2000279negative regulation of DNA biosynthetic process-IDA16980615  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005667transcription factor complex-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27110300The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)Ma KClin Epigenetics