Gene: DGKB

1607
DAGK2|DGK|DGK-BETA
diacylglycerol kinase beta
protein-coding
7p21.2
Ensembl:ENSG00000136267 MIM:604070 Vega:OTTHUMG00000152477 UniprotKB:Q9Y6T7
NG_029494.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.351e-2 (AD)  9.333e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17602660chr7:14606660 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKAP50.956
LRRTM40.955
PTPRO0.955
NDST30.955
CAMK40.952
VSTM2A0.95
FRRS1L0.95
GABRA40.95
GABRB30.946
FGF140.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.608
MYL3-0.583
HEY2-0.578
CNN2-0.547
RAI14-0.546
MAGEA12-0.541
TGFB3-0.537
YES1-0.537
ROM1-0.536
RAB13-0.53

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DGKB mRNA"28973690
C496492abrineabrine results in decreased expression of DGKB mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of DGKB mRNA26690555
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of DGKB mRNA"19936710
D001280AtrazineAtrazine results in decreased expression of DGKB mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of DGKB mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DGKB mRNA22079614
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DGKB mRNA20360939
D004041Dietary FatsDietary Fats results in decreased expression of DGKB mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DGKB mRNA20360939
D005419FlavonoidsFlavonoids results in increased expression of DGKB mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of DGKB mRNA19167457
C004925methylmercuric chloridemethylmercuric chloride affects the expression of DGKB protein27012723
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of DGKB mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DGKB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DGKB mRNA"25554681
D010269ParaquatParaquat results in decreased expression of DGKB mRNA21371552
D059808PolyphenolsPolyphenols results in decreased expression of DGKB mRNA16293270
D011374ProgesteroneProgesterone results in decreased expression of DGKB mRNA21795739
D011441PropylthiouracilPropylthiouracil results in decreased expression of DGKB mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of DGKB gene28589171
C012589trichostatin Atrichostatin A results in decreased expression of DGKB mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of DGKB mRNA23179753
D014639VanadiumVanadium results in increased expression of DGKB mRNA19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003951NAD+ kinase activity-IEA-  
GO:0004143diacylglycerol kinase activity-IDA22627129  
GO:0004143diacylglycerol kinase activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0030168platelet activation-TAS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0046486glycerolipid metabolic process-IDA22627129  
GO:0046834lipid phosphorylation-IDA22627129  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal