Gene: SLFN5

162394
-
schlafen family member 5
protein-coding
17q12
Ensembl:ENSG00000166750 MIM:614952 Vega:OTTHUMG00000179858 UniprotKB:Q08AF3
NC_000017.11
SNP Mapped
2   ANCO-SNPs
AD
0   
2.386e-1 (AD)  9.345e-1 (ND)   (Frontal_Cortex)
3.660e-1 (AD)  9.786e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs899940chr17:35259821 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9908966chr17:35256583 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LEPR0.735
FAT40.718
ELK40.71
MBOAT10.706
ATP7A0.706
DPYD0.703
SEPSECS0.699
PGR0.69
PALMD0.685
COL8A10.683

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.396
SLC29A4-0.388
NANOS3-0.367
WNT7B-0.366
SLC7A10-0.353
ARSF-0.351
PLA2G5-0.341
CCDC151-0.335
DBP-0.332
EPHB1-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLFN5 mRNA21420995|2649742
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLFN5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLFN5 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLFN5 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SLFN5 mRNA28522335
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLFN5 mRNA28522335
D000638AmiodaroneAmiodarone results in increased expression of SLFN5 mRNA19774075
C006632arsenic trioxidearsenic trioxide results in increased expression of SLFN5 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of SLFN5 mRNA27614199
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLFN5 mRNA20064835|2010694
D004958EstradiolEstradiol results in increased expression of SLFN5 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of SLFN5 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of SLFN5 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SLFN5 mRNA25181051
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SLFN5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SLFN5 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SLFN5 mRNA19159671|2010694
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SLFN5 mRNA27614199
C118739entinostatentinostat results in increased expression of SLFN5 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLFN5 mRNA20170705|2686566
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of SLFN5 mRNA27776689
C001277geldanamycingeldanamycin results in increased expression of SLFN5 mRNA26705709
D019833GenisteinGenistein affects the expression of SLFN5 mRNA26865667
D019833GenisteinGenistein results in increased expression of SLFN5 mRNA18847459
D017313FenretinideFenretinide results in decreased expression of SLFN5 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SLFN5 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLFN5 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SLFN5 mRNA21949397|2479639
C008261lead acetatelead acetate results in decreased expression of SLFN5 mRNA22641619
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLFN5 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLFN5 mRNA"20188158|2625132
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of SLFN5 promoter"26251327
D009532NickelNickel results in increased expression of SLFN5 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SLFN5 mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SLFN5 mRNA26705709
D010416PentachlorophenolPentachlorophenol results in increased expression of SLFN5 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLFN5 mRNA27614199
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of SLFN5 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of SLFN5 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLFN5 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of SLFN5 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of SLFN5 mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SLFN5 mRNA21334430
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SLFN5 mRNA27029645
C017947sodium arsenitesodium arsenite results in increased expression of SLFN5 mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of SLFN5 mRNA24383545
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLFN5 mRNA21570461
C011559tributyltintributyltin results in decreased expression of SLFN5 mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLFN5 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of SLFN5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLFN5 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of SLFN5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLFN5 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLFN5 gene25560391
C025643vinclozolinvinclozolin affects the expression of SLFN5 mRNA19015723
C111237vorinostatvorinostat results in increased expression of SLFN5 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of SLFN5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal