Gene info: ID 1630

Gene: DCC

GENE ID: 1630

Description: DCC netrin 1 receptor

Gene type: protein-coding

Location: 18q21.2

dbXrefs: Ensembl:ENSG00000187323 MIM:120470 Vega:OTTHUMG00000132698 UniprotKB:P43146

RefSeq: NG_013341.2

Retrived from: PubMed|SNP Mapped

SNPs: 8 ANCO-SNPs

Phenotype: ND|AD

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.773e-1 (AD) 7.516e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10469016	chr18:52800515 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs10515956	chr18:52782062 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs6508159	chr18:52761650 (GRCh38.p7)	C>A / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10083941	chr18:52755752 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1221884	chr18:52608976 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs1221877	chr18:52607456 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs1221874	chr18:52604740 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs1221872	chr18:52603967 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDKL5	0.915
PLEKHM3	0.908
KLHL11	0.907
GRM5	0.901
PPM1E	0.893
CDH7	0.878
PCDHAC1	0.876
PLCXD2	0.875
SLC9A7	0.875
PCDHAC2	0.872

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB13	-0.537
ROM1	-0.534
COPZ2	-0.52
RARRES2	-0.497
S100A1	-0.493
MPST	-0.485
BCL7C	-0.485
PPP1R14B	-0.481
GNG5	-0.481
HIST1H1C	-0.48

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
D000082	Acetaminophen	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DCC mRNA	25607892
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of DCC mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of DCC mRNA]	12205029
D000726	Androgen Antagonists	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DCC mRNA	25607892
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DCC mRNA	11940349
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DCC mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DCC mRNA	27858113
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DCC mRNA	27858113
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DCC mRNA	25607892
C006780	bisphenol A	bisphenol A results in decreased expression of DCC mRNA	25181051
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DCC mRNA	25607892
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DCC mRNA	27858113
D002922	Ciguatoxins	Ciguatoxins affects the expression of DCC mRNA	18353800
D019327	Copper Sulfate	Copper Sulfate affects the expression of DCC mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of DCC mRNA	26577399
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of DCC mRNA	23914054
C014347	decitabine	decitabine results in increased expression of DCC mRNA	19329758
D013759	Dronabinol	Dronabinol results in increased expression of DCC mRNA	17578508
D003993	Dibutyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DCC mRNA	21266533
D003633	Dichlorodiphenyl Dichloroethylene	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
D004051	Diethylhexyl Phthalate	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DCC mRNA	15766595
C118739	entinostat	entinostat results in increased expression of DCC mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DCC mRNA	25607892
C109476	epoxiconazole	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
C063007	exoenzyme C3, Clostridium botulinum	"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of DCC protein]"	24203571
D005472	Fluorouracil	DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole]	15148649
D004397	Fonofos	Fonofos results in increased methylation of DCC promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of DCC mRNA	12679049
D007854	Lead	Lead affects the expression of DCC mRNA	28903495
C065536	lead titanate zirconate	"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of DCC protein]"	24203571
C065536	lead titanate zirconate	lead titanate zirconate results in decreased expression of DCC protein	24203571
D008044	Linuron	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
D008713	Methimazole	Methimazole results in increased expression of DCC protein	22504374
D009151	Mustard Gas	Mustard Gas results in increased expression of DCC mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DCC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DCC mRNA"	25554681
D009532	Nickel	Nickel affects the expression of DCC mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of DCC mRNA]	14575637
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DCC mRNA	25607892
D010100	Oxygen	Oxygen deficiency results in increased expression of DCC mRNA	17914565
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of DCC mRNA	26272509
D010278	Parathion	Parathion results in increased methylation of DCC promoter	22847954
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C006253	pirinixic acid	pirinixic acid results in increased expression of DCC mRNA	20813756
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of DCC mRNA	23608068
C045362	prochloraz	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
C035988	procymidone	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
D011441	Propylthiouracil	Propylthiouracil results in increased expression of DCC mRNA	24780913
D011441	Propylthiouracil	Propylthiouracil results in increased expression of DCC protein	22504374
C017947	sodium arsenite	sodium arsenite affects the methylation of DCC gene	28589171
D013311	Streptozocin	NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC mRNA]	29059224
D013311	Streptozocin	NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC protein]	29059224
D013311	Streptozocin	Streptozocin results in increased expression of DCC mRNA	29059224
D013311	Streptozocin	Streptozocin results in increased expression of DCC protein	29059224
C003377	taxifolin	taxifolin results in increased expression of DCC mRNA	17541156
C012568	terbufos	terbufos results in increased methylation of DCC promoter	22847954
D007978	Levamisole	DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole]	15148649
D013849	Thimerosal	Thimerosal results in increased expression of DCC mRNA	27188386
D014118	Toxins, Biological	"Toxins, Biological affects the expression of DCC mRNA"	19682533
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of DCC mRNA]	14575637
C012589	trichostatin A	trichostatin A results in increased expression of DCC mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of DCC mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of DCC mRNA	24383497\|2493525
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of DCC gene	25560391
C025643	vinclozolin	[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA	25607892
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DCC mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of DCC mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	TAS	8861902
GO:0005042	netrin receptor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	11527412 12011067 16537496 18585357 19721007 20434207 21642953 22084112 26190107

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001764	neuron migration	-	IEA	-
GO:0006915	apoptotic process	-	TAS	9796814
GO:0007409	axonogenesis	-	TAS	8861902
GO:0007411	axon guidance	-	TAS	-
GO:0010977	negative regulation of neuron projection development	-	TAS	19616629
GO:0021965	spinal cord ventral commissure morphogenesis	-	IEA	-
GO:0033563	dorsal/ventral axon guidance	-	IEA	-
GO:0033564	anterior/posterior axon guidance	-	IEA	-
GO:0038007	netrin-activated signaling pathway	-	IEA	-
GO:0048671	negative regulation of collateral sprouting	-	TAS	19616629
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	-	TAS	-
GO:1901214	regulation of neuron death	-	IMP	21085126
GO:2000171	negative regulation of dendrite development	-	TAS	19616629

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0030424	axon	-	IEA	-

KEGG ID	KEGG Term
hsa04360	Axon guidance
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-373752	Netrin-1 signaling	TAS
R-HSA-373752	Netrin-1 signaling	IEA
R-HSA-376172	DSCAM interactions	IEA
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-418885	DCC mediated attractive signaling	TAS
R-HSA-418885	DCC mediated attractive signaling	IEA
R-HSA-418886	Netrin mediated repulsion signals	IEA
R-HSA-418889	Ligand-independent caspase activation via DCC	TAS
R-HSA-418890	Role of second messengers in netrin-1 signaling	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-428542	Regulation of commissural axon pathfinding by SLIT and ROBO	IEA
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	TAS
R-HSA-5357801	Programmed Cell Death	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20592015	Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. (2010 Jul 1)	Ostrow KL	Clin Cancer Res
12048974	[Etiopathogenic factors in colorectal cancer. Genetic and clinical features (first of 2 parts)]. (2002 Mar-Apr)	Casimiro C	Nutr Hosp
23435205	Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. (2013 Apr 1)	Brait M	Cell Cycle
23765761	Role of genetic variants of deleted in colorectal carcinoma (DCC) polymorphisms and esophageal and gastric cancers risk in Kashmir Valley and meta-analysis. (2013 Oct)	Malik MA	Tumour Biol
16337851	Deletion mapping of 18q in conventional renal cell carcinoma. (2005 Dec)	Hirata H	Cancer Genet Cytogenet
27535133	A Process Evaluation of the WV Smoking Cessation and Reduction in Pregnancy Treatment (SCRIPT) Dissemination Initiative: Assessing the Fidelity and Impact of Delivery for State-Wide, Home-Based Healthy Start Services. (2017 Jan)	Windsor R	Matern Child Health J
7557283	[Etiology of colorectal cancer]. (1994 Oct-Dec)	Matos Villalobos M	G E N
25249451	Association of DCC, MLH1, GSTT1, GSTM1, and TP53 gene polymorphisms with colorectal cancer in Kazakhstan. (2015 Jan)	Djansugurova L	Tumour Biol