Gene: TDRD5

163589
TUDOR3
tudor domain containing 5
protein-coding
1q25.2
Ensembl:ENSG00000162782 MIM:617748 Vega:OTTHUMG00000035259 UniprotKB:Q8NAT2
NG_053092.1
SNP Mapped
1   ANCO-SNPs
AD
0   
5.484e-2 (AD)  9.935e-1 (ND)   (Frontal_Cortex)
1.883e-3 (AD)  6.834e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16854429chr1:179640454 (GRCh38.p7)G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAH60.763
EPHA70.749
CDH120.749
NEK100.744
ANO30.743
RNF1500.737
STRIP20.734
NPY5R0.734
MAD2L10.732
DGKI0.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.469
C1QTNF5-0.466
MYL3-0.448
MAPKAPK3-0.446
TMEM102-0.444
ROM1-0.435
YES1-0.43
FLT3LG-0.428
PPP1R14B-0.416
FKBP10-0.415

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDRD5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDRD5 mRNA"27188386
C006780bisphenol Abisphenol A affects the expression of TDRD5 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TDRD5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TDRD5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TDRD5 gene28505145
C014347decitabinedecitabine affects the expression of TDRD5 mRNA23300844
D002945CisplatinCisplatin affects the expression of TDRD5 mRNA23300844
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TDRD5 mRNA28123099
D004397FonofosFonofos results in increased methylation of TDRD5 promoter22847954
C039281furanfuran results in increased methylation of TDRD5 gene22079235
D010278ParathionParathion results in increased methylation of TDRD5 promoter22847954
D010416PentachlorophenolPentachlorophenol results in increased expression of TDRD5 mRNA24642059
C006253pirinixic acidpirinixic acid results in increased expression of TDRD5 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of TDRD5 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of TDRD5 mRNA22238285
C012568terbufosterbufos results in increased methylation of TDRD5 promoter22847954
C012589trichostatin Atrichostatin A results in decreased expression of TDRD5 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDRD5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TDRD5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TDRD5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of TDRD5 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of TDRD5 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007286spermatid development-ISS-  
GO:0030719P granule organization-ISS-  
GO:0043046DNA methylation involved in gamete generation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0033391chromatoid body-ISS-  
GO:0071546pi-body-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal