Gene info: ID 1655

Gene: DDX5

GENE ID: 1655

Synonyms: G17P1|HLR1|HUMP68|p68

Description: DEAD-box helicase 5

Gene type: protein-coding

Location: 17q23.3

dbXrefs: Ensembl:ENSG00000108654 MIM:180630 Vega:OTTHUMG00000178936 UniprotKB:P17844

RefSeq: NC_000017.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.908e-1 (AD) 9.329e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs16947824	chr17:64505387 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SF3B1	0.949
XRN2	0.933
RBM39	0.931
PRPF4B	0.926
HNRNPH1	0.924
CUL4A	0.923
GPBP1L1	0.923
UBXN4	0.919
PICALM	0.917
SRSF1	0.915

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.785
OR4F29	-0.763
HES5	-0.184
REN	-0.15
LCE3B	-0.106
NANOGNB	-0.104
SPRR2D	-0.099
KRTAP19-1	-0.098
NXNL1	-0.098
SPRR2A	-0.097

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in decreased expression of DDX5 mRNA"	26377693
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DDX5 mRNA	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DDX5 mRNA"	25614096
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DDX5 mRNA"	21346803
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DDX5 mRNA]"	19467301
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of DDX5 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of DDX5 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DDX5 gene	27153756
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]	29094188
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDX5 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DDX5 protein	25419056
D001241	Aspirin	Aspirin results in increased expression of DDX5 mRNA	15928584
D001280	Atrazine	Atrazine results in decreased expression of DDX5 mRNA	22378314
C030935	benz(a)anthracene	benz(a)anthracene affects the expression of DDX5 mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA	27858113
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDX5 mRNA	20127859\|2234223
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DDX5 mRNA"	26238291
D004958	Estradiol	Estradiol affects the expression of DDX5 mRNA	23557687
C006780	bisphenol A	bisphenol A affects the expression of DDX5 mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased methylation of DDX5 promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of DDX5 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of DDX5 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA	28628672
C013418	bromfenacoum	bromfenacoum results in increased expression of DDX5 protein	28903499
C515564	bromovanin	bromovanin results in decreased expression of DDX5 protein	21419150
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DDX5 mRNA	23741332
D002220	Carbamazepine	Carbamazepine affects the expression of DDX5 mRNA	24752500
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of DDX5 mRNA	23650126
C100187	chloropicrin	chloropicrin results in decreased expression of DDX5 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDX5 gene	20938992
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA	27858113
C031180	chrysene	chrysene results in increased expression of DDX5 mRNA	26377693
D003033	Coal Tar	Coal Tar results in decreased expression of DDX5 mRNA	27858113
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DDX5 mRNA	19549813
C030973	cupric oxide	cupric oxide results in increased expression of DDX5 protein	25470785
C009160	cyclonite	cyclonite results in decreased expression of DDX5 mRNA	20965580
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DDX5 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of DDX5 protein	22023808
D004008	Diclofenac	Diclofenac affects the expression of DDX5 mRNA	24752500
C000944	dicrotophos	dicrotophos results in decreased expression of DDX5 mRNA	28302478
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of DDX5 mRNA	17490981
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DDX5 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of DDX5 mRNA	19467301
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DDX5 mRNA"	21785161
D004221	Disulfiram	Disulfiram results in decreased expression of DDX5 mRNA	20530235
D004237	Diuron	Diuron results in decreased expression of DDX5 mRNA	21551480
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DDX5 protein	23301498
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of DDX5 mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of DDX5 gene	27776689
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DDX5 mRNA	28329830
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDX5 gene	20938992
C010974	glyphosate	[Surface-Active Agents co-treated with glyphosate] results in increased expression of DDX5 mRNA	22467014
C010974	glyphosate	glyphosate results in increased expression of DDX5 mRNA	25636363
D017313	Fenretinide	Fenretinide results in decreased expression of DDX5 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of DDX5 mRNA	20044591
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA	28628672
D007559	Ivermectin	Ivermectin results in increased expression of DDX5 mRNA	26471037
C410337	K 7174	K 7174 results in increased expression of DDX5 mRNA	24086573
D007657	Ketone Bodies	Ketone Bodies results in increased expression of DDX5 mRNA	16807920
C017461	lead nitrate	[nickel chloride co-treated with lead nitrate] results in increased expression of DDX5 mRNA	19187980
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA	18386188
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of DDX5 mRNA	20353558
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDX5 gene	20938992
D008727	Methotrexate	Methotrexate affects the expression of DDX5 mRNA	18502557
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]	29094188
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of DDX5 mRNA	29094188
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DDX5 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DDX5 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DDX5 mRNA	23649840
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]	17220478
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DDX5 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DDX5 mRNA"	25554681\|2562005
C022838	nickel chloride	[nickel chloride co-treated with lead nitrate] results in increased expression of DDX5 mRNA	19187980
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of DDX5 mRNA	17616710
C016030	pantogab	pantogab results in increased expression of DDX5 mRNA	17379144
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA	18386188
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of DDX5 mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DDX5 protein	26879310
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of DDX5 mRNA	26272509
D011794	Quercetin	Quercetin results in decreased expression of DDX5 protein	19207037
C017947	sodium arsenite	sodium arsenite results in decreased expression of DDX5 mRNA	19072884
D053260	Soot	Soot results in decreased expression of DDX5 mRNA	26551751
D013501	Surface-Active Agents	[Surface-Active Agents co-treated with glyphosate] results in increased expression of DDX5 mRNA	22467014
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDX5 mRNA	21570461\|2468072
D013893	Thiram	Thiram results in decreased expression of DDX5 mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in decreased expression of DDX5 mRNA	27760801
C012589	trichostatin A	trichostatin A results in decreased expression of DDX5 mRNA	24935251
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of DDX5 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of DDX5 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of DDX5 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0003724	RNA helicase activity	-	IMP	21343338
GO:0003724	RNA helicase activity	-	NAS	1996094
GO:0003730	mRNA 3'-UTR binding	-	IDA	23788676
GO:0005515	protein binding	-	IPI	10837141 12527917 15113910 15298701 15660129 15846844 17011493 17932509 17960593 18457437 18548003 19626115 20676135 20818423 21343338 21911577 21994455 22222205 22266867 22365833 22640416 23143267 23741449 23788676 24219989 24581491 24910439 24965446 26420826
GO:0005516	calmodulin binding	-	IEA	-
GO:0005524	ATP binding	-	IEA	-
GO:0019899	enzyme binding	-	IEA	-
GO:0035500	MH2 domain binding	-	IPI	18548003
GO:0036002	pre-mRNA binding	-	IDA	21343338
GO:0043021	ribonucleoprotein complex binding	-	IDA	23788676
GO:0046332	SMAD binding	-	IPI	18548003
GO:0048306	calcium-dependent protein binding	-	IEA	-
GO:0050681	androgen receptor binding	-	IDA	18829551
GO:0070412	R-SMAD binding	-	IPI	18548003
GO:0070878	primary miRNA binding	-	IDA	18548003
GO:1990841	promoter-specific chromatin binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	15298701
GO:0000380	alternative mRNA splicing, via spliceosome	-	IMP	24275493 24910439
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	-	IDA	21343338
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	-	IMP	23022728
GO:0000398	mRNA splicing, via spliceosome	-	IC	11991638
GO:0000398	mRNA splicing, via spliceosome	-	TAS	-
GO:0000956	nuclear-transcribed mRNA catabolic process	-	IDA	23788676
GO:0001837	epithelial to mesenchymal transition	-	IMP	24910439
GO:0006357	regulation of transcription by RNA polymerase II	-	IMP	24275493
GO:0009299	mRNA transcription	-	IMP	23143267
GO:0030509	BMP signaling pathway	-	IMP	18548003
GO:0030520	intracellular estrogen receptor signaling pathway	-	IMP	24275493
GO:0030521	androgen receptor signaling pathway	-	IMP	24275493
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	-	IMP	15660129
GO:0045069	regulation of viral genome replication	-	IEA	-
GO:0045445	myoblast differentiation	-	ISS	-
GO:0045667	regulation of osteoblast differentiation	-	ISS	-
GO:0048511	rhythmic process	-	IEA	-
GO:0060765	regulation of androgen receptor signaling pathway	-	IMP	18829551
GO:0061614	pri-miRNA transcription by RNA polymerase II	-	ISS	-
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	-	IMP	15660129
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	NOT	IMP	18548003
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	-	IMP	18548003
GO:2001014	regulation of skeletal muscle cell differentiation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	16791210
GO:0005634	nucleus	-	IDA	24910439
GO:0005634	nucleus	-	NAS	2451786
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IDA	10837141
GO:0016020	membrane	-	HDA	19946888
GO:0070062	extracellular exosome	-	HDA	19056867
GO:0071013	catalytic step 2 spliceosome	-	IDA	11991638
GO:1990904	ribonucleoprotein complex	-	IDA	18809582

KEGG ID	KEGG Term
hsa03040	Spliceosome

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-72163	mRNA Splicing - Major Pathway	TAS
R-HSA-72172	mRNA Splicing	TAS
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal