Gene: DDX5

1655
G17P1|HLR1|HUMP68|p68
DEAD-box helicase 5
protein-coding
17q23.3
Ensembl:ENSG00000108654 MIM:180630 Vega:OTTHUMG00000178936 UniprotKB:P17844
NC_000017.11
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.908e-1 (AD)  9.329e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16947824chr17:64505387 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SF3B10.949
XRN20.933
RBM390.931
PRPF4B0.926
HNRNPH10.924
CUL4A0.923
GPBP1L10.923
UBXN40.919
PICALM0.917
SRSF10.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.785
OR4F29-0.763
HES5-0.184
REN-0.15
LCE3B-0.106
NANOGNB-0.104
SPRR2D-0.099
KRTAP19-1-0.098
NXNL1-0.098
SPRR2A-0.097

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of DDX5 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DDX5 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DDX5 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DDX5 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DDX5 mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DDX5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DDX5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DDX5 gene27153756
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]29094188
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DDX5 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of DDX5 protein25419056
D001241AspirinAspirin results in increased expression of DDX5 mRNA15928584
D001280AtrazineAtrazine results in decreased expression of DDX5 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene affects the expression of DDX5 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDX5 mRNA20127859|2234223
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DDX5 mRNA"26238291
D004958EstradiolEstradiol affects the expression of DDX5 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of DDX5 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of DDX5 promoter27312807
C006780bisphenol Abisphenol A affects the expression of DDX5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DDX5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA28628672
C013418bromfenacoumbromfenacoum results in increased expression of DDX5 protein28903499
C515564bromovaninbromovanin results in decreased expression of DDX5 protein21419150
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DDX5 mRNA23741332
D002220CarbamazepineCarbamazepine affects the expression of DDX5 mRNA24752500
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DDX5 mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of DDX5 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDX5 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DDX5 mRNA27858113
C031180chrysenechrysene results in increased expression of DDX5 mRNA26377693
D003033Coal TarCoal Tar results in decreased expression of DDX5 mRNA27858113
D019327Copper SulfateCopper Sulfate results in increased expression of DDX5 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of DDX5 protein25470785
C009160cyclonitecyclonite results in decreased expression of DDX5 mRNA20965580
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DDX5 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of DDX5 protein22023808
D004008DiclofenacDiclofenac affects the expression of DDX5 mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of DDX5 mRNA28302478
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of DDX5 mRNA17490981
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DDX5 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of DDX5 mRNA19467301
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DDX5 mRNA"21785161
D004221DisulfiramDisulfiram results in decreased expression of DDX5 mRNA20530235
D004237DiuronDiuron results in decreased expression of DDX5 mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DDX5 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DDX5 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DDX5 gene27776689
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DDX5 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDX5 gene20938992
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of DDX5 mRNA22467014
C010974glyphosateglyphosate results in increased expression of DDX5 mRNA25636363
D017313FenretinideFenretinide results in decreased expression of DDX5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DDX5 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DDX5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DDX5 mRNA28628672
D007559IvermectinIvermectin results in increased expression of DDX5 mRNA26471037
C410337K 7174K 7174 results in increased expression of DDX5 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of DDX5 mRNA16807920
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of DDX5 mRNA19187980
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA18386188
D008627Mercuric ChlorideMercuric Chloride affects the expression of DDX5 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DDX5 gene20938992
D008727MethotrexateMethotrexate affects the expression of DDX5 mRNA18502557
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]29094188
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DDX5 mRNA29094188
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DDX5 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DDX5 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DDX5 mRNA23649840
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]17220478
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DDX5 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDX5 mRNA"25554681|2562005
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of DDX5 mRNA19187980
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of DDX5 mRNA17616710
C016030pantogabpantogab results in increased expression of DDX5 mRNA17379144
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA18386188
D010416PentachlorophenolPentachlorophenol results in decreased expression of DDX5 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DDX5 protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DDX5 mRNA26272509
D011794QuercetinQuercetin results in decreased expression of DDX5 protein19207037
C017947sodium arsenitesodium arsenite results in decreased expression of DDX5 mRNA19072884
D053260SootSoot results in decreased expression of DDX5 mRNA26551751
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of DDX5 mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDX5 mRNA21570461|2468072
D013893ThiramThiram results in decreased expression of DDX5 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of DDX5 mRNA27760801
C012589trichostatin Atrichostatin A results in decreased expression of DDX5 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX5 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DDX5 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DDX5 gene25560391
C025643vinclozolinvinclozolin affects the expression of DDX5 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003724RNA helicase activity-IMP21343338  
GO:0003724RNA helicase activity-NAS1996094  
GO:0003730mRNA 3'-UTR binding-IDA23788676  
GO:0005515protein binding-IPI10837141  12527917  15113910  15298701  15660129  15846844  
17011493  17932509  17960593  18457437  18548003  19626115  
20676135  20818423  21343338  21911577  21994455  22222205  
22266867  22365833  22640416  23143267  23741449  23788676  
24219989  24581491  24910439  24965446  26420826  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0019899enzyme binding-IEA-  
GO:0035500MH2 domain binding-IPI18548003  
GO:0036002pre-mRNA binding-IDA21343338  
GO:0043021ribonucleoprotein complex binding-IDA23788676  
GO:0046332SMAD binding-IPI18548003  
GO:0048306calcium-dependent protein binding-IEA-  
GO:0050681androgen receptor binding-IDA18829551  
GO:0070412R-SMAD binding-IPI18548003  
GO:0070878primary miRNA binding-IDA18548003  
GO:1990841promoter-specific chromatin binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15298701  
GO:0000380alternative mRNA splicing, via spliceosome-IMP24275493  24910439  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IDA21343338  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IMP23022728  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0000956nuclear-transcribed mRNA catabolic process-IDA23788676  
GO:0001837epithelial to mesenchymal transition-IMP24910439  
GO:0006357regulation of transcription by RNA polymerase II-IMP24275493  
GO:0009299mRNA transcription-IMP23143267  
GO:0030509BMP signaling pathway-IMP18548003  
GO:0030520intracellular estrogen receptor signaling pathway-IMP24275493  
GO:0030521androgen receptor signaling pathway-IMP24275493  
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator-IMP15660129  
GO:0045069regulation of viral genome replication-IEA-  
GO:0045445myoblast differentiation-ISS-  
GO:0045667regulation of osteoblast differentiation-ISS-  
GO:0048511rhythmic process-IEA-  
GO:0060765regulation of androgen receptor signaling pathway-IMP18829551  
GO:0061614pri-miRNA transcription by RNA polymerase II-ISS-  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IMP15660129  
GO:1902893regulation of pri-miRNA transcription by RNA polymerase IINOTIMP18548003  
GO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA-IMP18548003  
GO:2001014regulation of skeletal muscle cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA16791210  
GO:0005634nucleus-IDA24910439  
GO:0005634nucleus-NAS2451786  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA10837141  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA19056867  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
GO:1990904ribonucleoprotein complex-IDA18809582  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal