Gene: DOCK1

1793
DOCK180|ced5
dedicator of cytokinesis 1
protein-coding
10q26.2
Ensembl:ENSG00000150760 MIM:601403 Vega:OTTHUMG00000019249 UniprotKB:Q14185
NG_033919.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.123e-1 (AD)  6.021e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11018077chr10:127429224 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01039092chr10:129245398DOCK1Gene body2.354e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZCCHC240.923
HIPK20.886
KIF5B0.878
KIF13A0.863
MTMR100.863
QKI0.859
TJP10.859
YES10.857
NEK70.857
FGF10.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTP1-0.556
TPBG-0.547
KCNB2-0.546
FBLN7-0.54
ANKRD34C-0.534
MCHR1-0.533
AGBL4-0.531
KCNK3-0.529
PRSS12-0.528
RGS6-0.528

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of DOCK1 mRNA20829426
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of DOCK1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of DOCK1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of DOCK1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of DOCK1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DOCK1 mRNA21641981|2210060
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DOCK1 mRNA24449571
D001151ArsenicArsenic results in increased methylation of DOCK1 gene24525453
D001280AtrazineAtrazine results in decreased expression of DOCK1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK1 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DOCK1 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of DOCK1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DOCK1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of DOCK1 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of DOCK1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of DOCK1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of DOCK1 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DOCK1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DOCK1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DOCK1 mRNA19561079|2739243
D002945CisplatinCisplatin results in decreased expression of DOCK1 mRNA22023808
D000431EthanolEthanol results in decreased expression of DOCK1 mRNA29018328
C540355fenamidonefenamidone results in increased expression of DOCK1 mRNA27029645
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DOCK1 mRNA27392435
C008261lead acetatelead acetate results in increased expression of DOCK1 mRNA20542052
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DOCK1 mRNA23103053
D009151Mustard GasMustard Gas affects the expression of DOCK1 mRNA15651846
C025589ochratoxin Aochratoxin A results in increased methylation of DOCK1 gene26431795
D011374ProgesteroneProgesterone results in decreased expression of DOCK1 mRNA19690047
C017947sodium arsenitesodium arsenite results in increased expression of DOCK1 mRNA21297353
C016104sodium bichromatesodium bichromate affects the expression of DOCK1 mRNA22110744
D019311StaurosporineDOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]25586182
D019311StaurosporineDOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]25586182
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of DOCK1 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DOCK1 mRNA21570461
D013792ThalidomideThalidomide results in increased expression of DOCK1 mRNA19751816
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DOCK1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of DOCK1 gene26756918
D014212TretinoinTretinoin results in increased expression of DOCK1 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DOCK1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DOCK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of DOCK1 gene29154799
D014810Vitamin EVitamin E results in decreased expression of DOCK1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activitycontributes_toIDA12134158  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005096GTPase activator activity-IEA-  
GO:0005515protein binding-IPI11240126  12134158  15247908  15723800  17474147  17515907  
18768751  19118547  20936779  
GO:0017124SH3 domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006911phagocytosis, engulfment-TAS9548255  
GO:0006915apoptotic process-IEA-  
GO:0007010cytoskeleton organization-IEA-  
GO:0007165signal transduction-TAS8661160  
GO:0007229integrin-mediated signaling pathway-TAS9808620  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0010634positive regulation of epithelial cell migration-IMP19004829  
GO:0016477cell migration-IEA-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IMP19004829  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IDA17515907  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
GO:0016607nuclear speck-IDA-  
GO:0032045guanyl-nucleotide exchange factor complex-IDA12134158  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-373752Netrin-1 signalingTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-418885DCC mediated attractive signalingTAS
R-HSA-418885DCC mediated attractive signalingIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28044437Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. (2017 Jun)McDonald MNJ Cachexia Sarcopenia Muscle