Gene: DOCK3

1795
MOCA|PBP
dedicator of cytokinesis 3
protein-coding
3p21.2
Ensembl:ENSG00000088538 MIM:603123 Vega:OTTHUMG00000156892 UniprotKB:Q8IZD9
NG_028012.1
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.414e-1 (AD)  7.670e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2306431chr3:51356026 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4974096chr3:51355615 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17051755chr3:51349616 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7635095chr3:51345221 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7642077chr3:51345170 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7630259chr3:51341117 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17051404chr3:50714419 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MADD0.978
TLN20.976
MYH100.975
ADD20.972
PI4KA0.971
FAM131B0.969
INPP4A0.968
HSPA12A0.968
KALRN0.967
SV2B0.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.52
HEY2-0.516
RNF135-0.511
MYL3-0.508
CSAG1-0.502
WWTR1-0.499
YES1-0.499
TFPI2-0.498
COPZ2-0.488
ZNF114-0.485

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DOCK3 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DOCK3 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DOCK3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK3 mRNA"27188386
C006632arsenic trioxidearsenic trioxide results in increased expression of DOCK3 mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of DOCK3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK3 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK3 mRNA20064835
C006780bisphenol Abisphenol A results in decreased methylation of DOCK3 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of DOCK3 mRNA20739668
C006780bisphenol Abisphenol A results in increased methylation of DOCK3 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of DOCK3 mRNA29097150
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of DOCK3 mRNA20971185
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA16963248
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DOCK3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DOCK3 mRNA27392435
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DOCK3 mRNA22129741
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DOCK3 mRNA29097150
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA16963248
D005839GentamicinsGentamicins results in decreased expression of DOCK3 mRNA22061828
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of DOCK3 mRNA16963248
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DOCK3 mRNA22129741
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DOCK3 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DOCK3 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DOCK3 mRNA"25620056
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of DOCK3 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased methylation of DOCK3 gene26431795
D010938Plant OilsPlant Oils results in increased expression of DOCK3 mRNA23370395
D053260SootSoot results in increased expression of DOCK3 mRNA26551751
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of DOCK3 mRNA25172293
D014241TrichloroethyleneTrichloroethylene results in increased methylation of DOCK3 gene27618143
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DOCK3 mRNA26272509|2800136
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DOCK3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  18984162  
GO:0017124SH3 domain binding-IEA-  
GO:0030676Rac guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:1903997positive regulation of non-membrane spanning protein tyrosine kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-9006115Signaling by NTRK2 (TRKB)TAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9032500Activated NTRK2 signals through FYNTAS
R-HSA-9032500Activated NTRK2 signals through FYNIEA
R-HSA-9032759NTRK2 activates RAC1TAS
R-HSA-9032759NTRK2 activates RAC1IEA
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal