Gene: DPP4

1803
ADABP|ADCP2|CD26|DPPIV|TP103
dipeptidyl peptidase 4
protein-coding
2q24.2
Ensembl:ENSG00000197635 MIM:102720 Vega:OTTHUMG00000132056 UniprotKB:P27487
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.538e-1 (AD)  5.948e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2268888chr2:162028940 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RXFP10.834
POU6F20.774
ISLR0.771
HS3ST20.759
CLSTN20.758
CADPS20.757
THEMIS0.754
FOXP20.75
NRG10.747
SLC24A20.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.557
LRAT-0.516
PON3-0.489
MYOM1-0.481
NKAIN3-0.469
RXRG-0.468
MRO-0.466
EYA1-0.465
ACOX2-0.463
C16orf74-0.454

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedTarget
DB01261SitagliptinSmall Molecule486460-32-6Approved|InvestigationalTarget
DB018842-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-OneSmall MoleculeExperimentalTarget
DB020045-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-AmineSmall MoleculeExperimentalTarget
DB03253(2s)-Pyrrolidin-2-YlmethylamineSmall MoleculeExperimentalTarget
DB036604-Iodo-L-phenylalanineSmall Molecule24250-85-9ExperimentalTarget
DB04491Diisopropylphosphono GroupSmall MoleculeExperimentalTarget
DB045771-(1-phenylcyclopentyl)methylamineSmall Molecule17511-89-6ExperimentalTarget
DB04578(S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamideSmall Molecule-ExperimentalTarget
DB04876VildagliptinSmall Molecule274901-16-5Approved|InvestigationalTarget
DB05001PSN9301Small Molecule-InvestigationalTarget
DB06127KRP-104Small Molecule-InvestigationalTarget
DB06203AlogliptinSmall Molecule850649-61-5ApprovedTarget
DB06335SaxagliptinSmall Molecule361442-04-8ApprovedTarget
DB06880(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINESmall MoleculeExperimentalTarget
DB06939N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDESmall MoleculeExperimentalTarget
DB06993(2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amineSmall MoleculeExperimentalTarget
DB06994(2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amineSmall MoleculeExperimentalTarget
DB07015(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amineSmall MoleculeExperimentalTarget
DB07021(7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amineSmall MoleculeExperimentalTarget
DB07067(2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINESmall MoleculeExperimentalTarget
DB07072(1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINESmall MoleculeExperimentalTarget
DB07081(2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINESmall MoleculeExperimentalTarget
DB07092(2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDESmall MoleculeExperimentalTarget
DB07135(2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDESmall MoleculeExperimentalTarget
DB07154(3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONESmall MoleculeExperimentalTarget
DB071814'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamideSmall MoleculeExperimentalTarget
DB07193(2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amineSmall MoleculeExperimentalTarget
DB072397-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrileSmall MoleculeExperimentalTarget
DB072714-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-oneSmall MoleculeExperimentalTarget
DB07328METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATESmall MoleculeExperimentalTarget
DB07356(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINESmall MoleculeExperimentalTarget
DB074121-biphenyl-2-ylmethanamineSmall MoleculeExperimentalTarget
DB07465(1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrileSmall MoleculeExperimentalTarget
DB07482(2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDESmall MoleculeExperimentalTarget
DB07666(3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINESmall MoleculeExperimentalTarget
DB07779N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDESmall MoleculeExperimentalTarget
DB07830(4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONESmall MoleculeExperimentalTarget
DB07851(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINESmall MoleculeExperimentalTarget
DB080241-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILESmall MoleculeExperimentalTarget
DB08044(1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINESmall MoleculeExperimentalTarget
DB08051(2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINESmall MoleculeExperimentalTarget
DB08164(3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINESmall MoleculeExperimentalTarget
DB08382GosogliptinSmall Molecule869490-23-3InvestigationalTarget
DB08429N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamideSmall MoleculeExperimentalTarget
DB08445(3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINESmall MoleculeExperimentalTarget
DB085046-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUMSmall MoleculeExperimentalTarget
DB085307-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONESmall MoleculeExperimentalTarget
DB085882-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILESmall MoleculeExperimentalTarget
DB086724-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDESmall MoleculeExperimentalTarget
DB087432-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILESmall MoleculeExperimentalTarget
DB08882LinagliptinSmall Molecule668270-12-0ApprovedTarget
DB11723DutogliptinSmall Molecule852329-66-9InvestigationalTarget
DB06655LiraglutideBiotechDrug204656-20-2ApprovedEnzyme
DB13928SemaglutideSmall Molecule910463-68-2Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5036341-(2-amino-3-methyl-butyryl)-azetidine-2-carbonitrile1-(2-amino-3-methyl-butyryl)-azetidine-2-carbonitrile results in decreased activity of DPP4 protein15925329
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of DPP4 mRNA"19162173
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of DPP4 mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DPP4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DPP4 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of DPP4 mRNA25088246
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of DPP4 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPP4 mRNA"27188386
C0194984-nitroaniline[DPP4 protein results in increased cleavage of alanylproline-4-nitroanilide] which results in increased abundance of 4-nitroaniline16725115
C0194984-nitroaniline[DPP4 protein results in increased cleavage of glycylproline 4-nitroanilide] which results in increased abundance of 4-nitroaniline16725115
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPP4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DPP4 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen results in increased expression of DPP4 protein22230336
D000082AcetaminophenAcetaminophen affects the expression of DPP4 mRNA17562736
D000241AdenosineAdenosine results in decreased expression of DPP4 mRNA16611738
D000241AdenosineAdenosine results in decreased expression of DPP4 protein16611738
D000241Adenosine[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA16611738
D000241Adenosine[Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein16611738
D000241Adenosine[Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA16611738
D000241Adenosine[Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein16611738
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DPP4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DPP4 mRNA19770486
C083013alanylproline-4-nitroanilideDPP4 protein results in increased cleavage of alanylproline-4-nitroanilide19188489
C083013alanylproline-4-nitroanilideDPP4 protein results in increased cleavage of alanylproline-4-nitroanilide17287297
C083013alanylproline-4-nitroanilideDPP4 protein results in increased cleavage of alanylproline-4-nitroanilide19188489
C083013alanylproline-4-nitroanilideDPP4 protein results in increased cleavage of alanylproline-4-nitroanilide16725115
C083013alanylproline-4-nitroanilide[DPP4 protein results in increased cleavage of alanylproline-4-nitroanilide] which results in increased abundance of 4-nitroaniline16725115
C107757alanylpyrrolidine-boronic acidalanylpyrrolidine-boronic acid results in decreased activity of DPP4 protein21388136
C520853alogliptinalogliptin binds to DPP4 protein24687332
C520853alogliptinalogliptin results in decreased activity of DPP4 protein22125632
C520853alogliptinalogliptin results in decreased activity of DPP4 protein19208898
D000638AmiodaroneAmiodarone affects the expression of DPP4 mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DPP4 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of DPP4 mRNA26238599
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of DPP4 mRNA17639512
D001379AzathioprineAzathioprine results in decreased expression of DPP4 mRNA12806628
C547126AZM551248AZM551248 results in increased expression of DPP4 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of DPP4 mRNA19483382
D001554BenzeneBenzene analog results in decreased activity of DPP4 protein17977724
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DPP4 mRNA]22228805
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of DPP4 mRNA17404688
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of DPP4 mRNA18192240
C118220bis(4-acetamidophenyl) 1-prolylpyrrolidine-2-phosphonatebis(4-acetamidophenyl) 1-prolylpyrrolidine-2-phosphonate results in decreased activity of DPP4 protein17287297
C006780bisphenol Abisphenol A results in increased expression of DPP4 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in decreased expression of DPP4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DPP4 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of DPP4 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DPP4 mRNA25993096
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA]"20230807
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DPP4 mRNA27339419
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of DPP4 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DPP4 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DPP4 mRNA28472532
C019304ciprofibrateciprofibrate results in decreased expression of DPP4 protein2404574
D002994ClofibrateClofibrate affects the expression of DPP4 mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of DPP4 protein2404574
D002995Clofibric AcidClofibric Acid affects the expression of DPP4 mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPP4 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of DPP4 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of DPP4 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of DPP4 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of DPP4 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of DPP4 mRNA19770486
D000069439DasatinibDasatinib results in increased expression of DPP4 mRNA20579391
C014347decitabinedecitabine affects the expression of DPP4 mRNA17145863
C016366dibenzothiophenedibenzothiophene results in increased expression of DPP4 mRNA23656968
C000944dicrotophosdicrotophos results in decreased expression of DPP4 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of DPP4 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of DPP4 mRNA19030233|2501614
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of DPP4 mRNA]19030233
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of DPP4 protein2404574
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPP4 mRNA17602206
D002117CalcitriolCalcitriol results in increased expression of DPP4 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate results in increased expression of DPP4 mRNA26924002
D004237DiuronDiuron metabolite results in increased expression of DPP4 mRNA24172598
D004237DiuronDiuron results in decreased expression of DPP4 mRNA25152437
D004317DoxorubicinDPP4 protein promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]15753397
D004317Doxorubicin[DPP4 protein results in increased expression of TOP2A protein] which results in increased susceptibility to Doxorubicin15753397
D004317DoxorubicinDPP4 protein results in increased susceptibility to Doxorubicin15753397
C118739entinostatentinostat results in increased expression of DPP4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPP4 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DPP4 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DPP4 mRNA17555576
D005001EthionineEthionine affects the expression of DPP4 mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DPP4 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of DPP4 mRNA24793618
D005485FlutamideFlutamide results in increased expression of DPP4 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of DPP4 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of DPP4 mRNA12679049
D005897GlafenineGlafenine results in decreased expression of DPP4 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of DPP4 mRNA22634610
C042892glycylproline 4-nitroanilideDPP4 protein results in increased cleavage of glycylproline 4-nitroanilide19188489
C042892glycylproline 4-nitroanilideDPP4 protein results in increased cleavage of glycylproline 4-nitroanilide17287297
C042892glycylproline 4-nitroanilideDPP4 protein results in increased cleavage of glycylproline 4-nitroanilide19188489
C042892glycylproline 4-nitroanilideDPP4 protein results in increased cleavage of glycylproline 4-nitroanilide16725115
C042892glycylproline 4-nitroanilide[DPP4 protein results in increased cleavage of glycylproline 4-nitroanilide] which results in increased abundance of 4-nitroaniline16725115
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of DPP4 mRNA25270620
D017313FenretinideFenretinide results in decreased expression of DPP4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of DPP4 mRNA28973697
C029424hydrazinehydrazine analog binds to DPP4 protein24687332
D007529IsoflavonesIsoflavones affects the expression of DPP4 mRNA16365062
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DPP4 mRNA23086925
C410337K 7174K 7174 results in decreased expression of DPP4 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of DPP4 mRNA22609695
D000069476LinagliptinLinagliptin results in decreased activity of DPP4 protein22125632
D008154LucanthoneLucanthone results in increased expression of DPP4 mRNA21148553
D008345ManganeseManganese results in increased expression of DPP4 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of DPP4 mRNA17175027
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DPP4 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DPP4 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA]"20230807
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of DPP4 mRNA24128854
C570834MK0626MK0626 inhibits the reaction [Tacrolimus results in increased activity of DPP4 protein]24959755
C570834MK0626MK0626 results in decreased activity of DPP4 protein24959755
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of DPP4 mRNA26924002
D009151Mustard GasMustard Gas affects the expression of DPP4 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DPP4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DPP4 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of DPP4 mRNA12540486
C029938nickel sulfatenickel sulfate results in decreased expression of DPP4 mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of DPP4 mRNA22714537
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA]"20230807
D009853OmeprazoleOmeprazole affects the expression of DPP4 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DPP4 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of DPP4 mRNA18636392
D010416PentachlorophenolPentachlorophenol results in increased expression of DPP4 mRNA23892564
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of DPP4 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DPP4 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of DPP4 mRNA12807726
C006253pirinixic acidpirinixic acid affects the expression of DPP4 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of DPP4 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of DPP4 protein2404574
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of DPP4 mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DPP4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DPP4 mRNA22079256
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of DPP4 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of DPP4 mRNA17404688|2154024
C045950propiconazolepropiconazole results in decreased expression of DPP4 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of DPP4 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of DPP4 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of DPP4 mRNA24780913
C477478PT-100 dipeptidePT-100 dipeptide results in decreased activity of DPP4 protein21388136
D011758PyrrolesPyrroles analog results in decreased activity of DPP4 protein17977724
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of DPP4 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of DPP4 mRNA21632981
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of DPP4 mRNA]19030233
D012402RotenoneRotenone results in increased expression of DPP4 protein25446674
D012402Rotenonesaxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]25446674
C502994saxagliptinsaxagliptin results in decreased activity of DPP4 protein21186796|2138813
C502994saxagliptinsaxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]25446674
C502994saxagliptinsaxagliptin results in decreased expression of DPP4 protein25446674
C502994saxagliptinsaxagliptin results in decreased activity of DPP4 protein20518802|2171105
D000068900Sitagliptin PhosphateSitagliptin Phosphate binds to DPP4 protein24687332
D000068900Sitagliptin PhosphateSitagliptin Phosphate results in decreased activity of DPP4 protein17977724|2067917
D000068900Sitagliptin PhosphateSitagliptin Phosphate results in decreased activity of DPP4 protein22125632
D000068900Sitagliptin PhosphateSitagliptin Phosphate results in decreased activity of DPP4 protein19188489|2051880
C017947sodium arsenitesodium arsenite results in increased expression of DPP4 mRNA22714537
D012969Sodium FluorideSodium Fluoride results in decreased expression of DPP4 mRNA27257137
D013311StreptozocinDPP4 results in increased susceptibility to Streptozocin18931022
D013311StreptozocinStreptozocin results in decreased activity of DPP4 protein18931022
D013311StreptozocinStreptozocin results in decreased expression of DPP4 protein16045816
D013311StreptozocinStreptozocin results in increased expression of DPP4 mRNA18931022
D016559TacrolimusMK0626 inhibits the reaction [Tacrolimus results in increased activity of DPP4 protein]24959755
D016559TacrolimusTacrolimus results in increased activity of DPP4 protein24959755
D013629TamoxifenTamoxifen affects the expression of DPP4 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of DPP4 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DPP4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DPP4 mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DPP4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DPP4 mRNA22808131
D013853ThioacetamideThioacetamide affects the expression of DPP4 mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of DPP4 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of DPP4 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DPP4 mRNA18087596
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DPP4 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of DPP4 mRNA26238599
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of DPP4 mRNA12163651
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DPP4 mRNA29024780
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of DPP4 mRNA15885361
D014635Valproic AcidValproic Acid affects the expression of DPP4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DPP4 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of DPP4 mRNA26238599|2915479
D014635Valproic AcidValproic Acid results in increased expression of DPP4 mRNA24489787
D014640VancomycinVancomycin results in increased expression of DPP4 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DPP4 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of DPP4 mRNA25423262
C502012vildagliptinvildagliptin results in decreased activity of DPP4 protein17287297|2138813
C502012vildagliptinvildagliptin results in decreased activity of DPP4 protein17986525|2051880
C025643vinclozolinvinclozolin affects the expression of DPP4 mRNA19015723
D014750VincristineVincristine results in decreased expression of DPP4 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of DPP4 mRNA26682919
C102817voglibosevoglibose results in decreased expression of and results in decreased activity of DPP4 protein19208898
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of DPP4 mRNA"23246600
C027368zomepirac glucuronidezomepirac glucuronide binds to DPP4 protein11895555

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IDA23486063  
GO:0002020protease binding-IPI16651416  
GO:0004252serine-type endopeptidase activity-EXP8100523  8798518  15584901  
GO:0005102signaling receptor binding-IPI10900005  
GO:0005515protein binding-IPI7594462  8101391  14684150  17287217  17549790  18275857  
21314817  22001206  23486063  23831647  
GO:0008236serine-type peptidase activity-IDA14684150  
GO:0008239dipeptidyl-peptidase activity-IDA10593948  14684150  16651416  17549790  27198182  
GO:0042802identical protein binding-IPI22001206  
GO:0042803protein homodimerization activity-IPI14684150  15448155  
GO ID GO Term Qualifier Evidence PubMed
GO:0001662behavioral fear response-IEA-  
GO:0001666response to hypoxia-IDA16670267  
GO:0006508proteolysis-IDA27198182  
GO:0007155cell adhesion-IEA-  
GO:0008284positive regulation of cell proliferation-IDA17549790  
GO:0010716negative regulation of extracellular matrix disassembly-IDA16651416  
GO:0031295T cell costimulation-IDA10900005  17287217  
GO:0033632regulation of cell-cell adhesion mediated by integrin-IDA11772392  
GO:0035641locomotory exploration behavior-IEA-  
GO:0036343psychomotor behavior-IEA-  
GO:0042110T cell activation-IDA7594462  
GO:0043542endothelial cell migration-IDA16651416  
GO:0046718viral entry into host cell-IEA-  
GO:0050796regulation of insulin secretion-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005886plasma membrane-IDA16670267  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA7594462  8101391  10900005  11772392  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IDA15052268  
GO:0030027lamellipodium-IDA16651416  
GO:0030139endocytic vesicle-IDA10900005  
GO:0031258lamellipodium membrane-IEA-  
GO:0045121membrane raft-IEA-  
GO:0046581intercellular canaliculus-IEA-  
GO:0070062extracellular exosome-HDA11487543  19056867  19199708  20458337  21362503  23533145  
GO:0071438invadopodium membrane-IDA16651416  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29020176DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients. (2018 Jan 6)Seys LJMClin Infect Dis
25633664Incretin-based therapy and risk of acute pancreatitis: a nationwide population-based case-control study. (2015 Jun)Thomsen RWDiabetes Care