Gene: EBF1

1879
COE1|EBF|O/E-1|OLF1
early B cell factor 1
protein-coding
5q33.3
Ensembl:ENSG00000164330 MIM:164343 Vega:OTTHUMG00000130304 UniprotKB:Q9UH73
NC_000005.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.843e-1 (AD)  7.825e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13174549chr5:159035468 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE5A0.861
FOXC10.858
TBX180.844
COL1A20.842
DCN0.842
MECOM0.83
GPX80.828
PALMD0.826
EMCN0.825
CFH0.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.584
HAS1-0.57
KCNB2-0.565
BCL11A-0.563
LRTM2-0.558
SVOP-0.556
LRFN2-0.554
SLC45A1-0.551
LRRC73-0.55
STOML1-0.549

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EBF1 mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF1 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EBF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EBF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EBF1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EBF1 mRNA16483693
C015001arsenitearsenite results in increased methylation of EBF1 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EBF1 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of EBF1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of EBF1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to EBF1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EBF1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EBF1 mRNA21839799
D004958EstradiolEstradiol results in decreased expression of EBF1 mRNA25210133
C006780bisphenol Abisphenol A results in decreased expression of EBF1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of EBF1 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of EBF1 gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EBF1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of EBF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EBF1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of EBF1 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EBF1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of EBF1 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of EBF1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EBF1 gene20938992
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of EBF1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of EBF1 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of EBF1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EBF1 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EBF1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of EBF1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of EBF1 mRNA27392435
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of EBF1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of EBF1 mRNA26033743
D004237DiuronDiuron results in decreased expression of EBF1 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EBF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EBF1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EBF1 mRNA17557909
C056516exemestaneexemestane results in increased expression of EBF1 mRNA17254854
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EBF1 gene20938992
D017313FenretinideFenretinide results in decreased expression of EBF1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EBF1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EBF1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EBF1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of EBF1 mRNA27392435
D008558MelphalanMelphalan results in decreased expression of EBF1 mRNA22363485
C042720mercuric bromidemercuric bromide results in decreased expression of EBF1 mRNA26272509
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EBF1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EBF1 mRNA23179753
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of EBF1 mRNA24810058
D008777MethyltestosteroneMethyltestosterone results in decreased expression of EBF1 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of EBF1 mRNA26518055
D009151Mustard GasMustard Gas results in increased expression of EBF1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EBF1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of EBF1 mRNA19812364
D009532NickelNickel results in decreased expression of EBF1 mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EBF1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of EBF1 mRNA25729387
D010100OxygenOxygen results in increased expression of EBF1 mRNA22911455
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EBF1 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EBF1 mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EBF1 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of EBF1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of EBF1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of EBF1 mRNA12832660
C043680ptaquilosideptaquiloside results in decreased expression of EBF1 mRNA23274088
C017947sodium arsenitesodium arsenite affects the expression of EBF1 mRNA29319823
C017947sodium arsenitesodium arsenite affects the methylation of EBF1 gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of EBF1 mRNA23274088
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of EBF1 mRNA22467014
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of EBF1 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EBF1 mRNA29107001
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EBF1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EBF1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EBF1 mRNA24058054
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EBF1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of EBF1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EBF1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EBF1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EBF1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of EBF1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EBF1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EBF1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of EBF1 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of EBF1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of EBF1 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EBF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EBF1 mRNA25716160
D014635Valproic AcidValproic Acid results in increased expression of EBF1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of EBF1 mRNA19136453
C025643vinclozolinvinclozolin affects the expression of EBF1 mRNA19015723
D014750VincristineVincristine results in increased expression of EBF1 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of EBF1 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EBF1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of EBF1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  25910212  
GO:0046872metal ion binding-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO:0070742C2H2 zinc finger domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer
29789399EBF1 Gene Polymorphism and Its Interaction with Smoking and Drinking on the Risk of Coronary Artery Disease for Chinese Patients. (2018 May 22)Ying YBiosci Rep